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RBP4 retinol binding protein 4 [ Sus scrofa (pig) ]

Gene ID: 397124, updated on 17-Aug-2024

Summary

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Official Symbol
RBP4provided by VGNC
Official Full Name
retinol binding protein 4provided by VGNC
Primary source
VGNC:VGNC:92164
See related
Ensembl:ENSSSCG00000010479
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Biased expression in liver (RPKM 521.6) and mixtures (RPKM 179.9) See more
Orthologs
human mouse all
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Genomic context

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See RBP4 in Genome Data Viewer
Location:
chromosome: 14
Exon count:
4
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 14 NC_010456.5 (105037360..105044552, complement)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 14 NC_010456.4 (114769053..114775781, complement)

Chromosome 14 - NC_010456.5Genomic Context describing neighboring genes Neighboring gene myoferlin Neighboring gene centrosomal protein 55 Neighboring gene phosphodiesterase 6C Neighboring gene FRA10A associated CGG repeat 1 Neighboring gene leucine rich glioma inactivated 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Association of RBP-4 gene polymorphisms with follicular cysts in large white sows. Wang F, et al. Reprod Domest Anim, 2019 Jul. PMID 31025395
  2. Retinol binding protein 4 affects the adipogenesis of porcine preadipocytes through insulin signaling pathways. Cheng J, et al. Biochem Cell Biol, 2013 Aug. PMID 23859018
  3. Effects of SNPs using differentially expressed serum proteins at growth stages on average daily gain in pig. Chung HY. Mol Biol Rep, 2011 Aug. PMID 21113678
  4. Retinol-binding protein: a major secretory product of the pig conceptus. Harney JP, et al. Biol Reprod, 1990 Mar. PMID 2340335
  5. The retinol-binding protein of the expanding pig blastocyst: molecular cloning and expression in trophectoderm and embryonic disc. Trout WE, et al. Mol Endocrinol, 1991 Oct. PMID 1723146

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We screened the mutations of RBP-4 gene in 79 sows with follicular cysts and 100 normal sows without cysts. Results showed that +249-63G>C polymorphisms were significantly associated with follicular cysts, and sows with CC genotype in RBP-4 gene had a high risk of developing follicular cysts.
    Title: Association of RBP-4 gene polymorphisms with follicular cysts in large white sows.
  2. There were no statistical differences between the BB genotype and the AB genotype of ESR2 locus in regard to the examined traits. However, a noticeable superiority (P < 0.01) of the BB genotype compared to the homozygous AA genotype, adding almost 2 piglets/litter in TNB and NBA trait, was found.
    Title: Association of BF, RBP4, and ESR2 Genotypes with Litter Size in an Autochthonous Pig Population.
  3. RBP4 has a role in adipogenesis of porcine preadipocytes through the insulin signaling pathways
    Title: Retinol binding protein 4 affects the adipogenesis of porcine preadipocytes through insulin signaling pathways.
  4. Data show that there were two genotypes for RBP4 gene in Tibet pig, which did not have significant effect on the reproductive traits.
    Title: [Effects of multi-genes for reproductive traits in Tibet pig].
  5. The aim of this work was to study the effects on litter size of variants of the porcine genes RBP4, ESR1 and IGF2, currently used in genetic tests for different purposes.
    Title: Non-additive effects of RBP4, ESR1 and IGF2 polymorphisms on litter size at different parities in a Chinese-European porcine line.
  6. The results showed that the polymorphic sites of both PRLR and RBP4 genes are closely related to litter size traits.
    Title: [Relationship of genetic polymorphism of PRLR and RBP4 genes with litter size traits in pig].
  7. study found significant association of two diallelic polymorphisms in the porcine genes for leukaemia inhibitory factor (LIF) and retinol-binding protein 4 (RBP4) with number of piglets born alive (NBA) in two German pig lines
    Title: Effect of polymorphisms in the genes for LIF and RBP4 on litter size in two German pig lines.
  8. Response to selection for increased litter size could not be attributed to effects at the estrogen receptor, retinol-binding protein or follistatin loci.
    Title: Characterization of a line of pigs previously selected for increased litter size for RBP4 and follistatin.
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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables retinol binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables retinol transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in retinol transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
retinol-binding protein 4
Names
PRBP
Plasma retinol-binding protein
RBP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_214057.1 → NP_999222.1  retinol-binding protein 4 precursor

    See identical proteins and their annotated locations for NP_999222.1

    Status: PROVISIONAL

    Source sequence(s)
    M68860
    UniProtKB/Swiss-Prot
    P27485
    Related
    ENSSSCP00000011168.2, ENSSSCT00000011467.5
    Conserved Domains (1) summary
    pfam00061
    Location:39 → 159
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010456.5 Reference Sscrofa11.1 Primary Assembly

    Range
    105037360..105044552 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021072103.1 → XP_020927762.1  retinol-binding protein 4 isoform X1

    UniProtKB/Swiss-Prot
    P27485
    UniProtKB/TrEMBL
    A0A4X1UUT1, F1SC80
    Conserved Domains (1) summary
    pfam00061
    Location:39 → 159
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RNA

  1. XR_002338287.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P27485.2 GenPept UniProtKB/Swiss-Prot:P27485

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.