txndc5.L thioredoxin domain containing 5 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: txndc5.L
Official Full Name: thioredoxin domain containing 5 L homeolog
Primary source: Xenbase:XB-GENE-490949
Locus tag: XELAEV_18031627mg
See related: EnsemblRapid:ENSXLAG00005017723 AllianceGenome:Xenbase:XB-GENE-490949
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: erp46; txndc5
Summary: Predicted to enable protein disulfide isomerase activity. Predicted to act upstream of or within protein folding. Predicted to be located in endoplasmic reticulum lumen. Orthologous to human TXNDC5 (thioredoxin domain containing 5). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 6L

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	6L	NC_054381.1 (94469426..94497111, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	6L	NC_030734.1 (87715807..87743713, complement)

Chromosome 6L - NC_054381.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables protein disulfide isomerase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within protein folding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: thioredoxin domain containing 5 L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001086975.1 → NP_001080444.1 thioredoxin domain containing 5 L homeolog precursor

See identical proteins and their annotated locations for NP_001080444.1

Status: PROVISIONAL

Source sequence(s)

BC045245

UniProtKB/TrEMBL

A0A974HFY5, Q7ZX44

Related

ENSXLAP00005052349.1, ENSXLAT00005053513.1

Conserved Domains (2) summary

cd03005
Location:163 → 262

PDI_a_ERp46; PDIa family, endoplasmic reticulum protein 46 (ERp46) subfamily; ERp46 is an ER-resident protein containing three redox active TRX domains. Yeast complementation studies show that ERp46 can substitute for protein disulfide isomerase (PDI) function in ...

TIGR01130
Location:36 → 403

ER_PDI_fam; protein disulfide isomerase, eukaryotic

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054381.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

94469426..94497111 complement

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GenBank, FASTA, Sequence Viewer (Graphics)