serpina1.S serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: serpina1.S
Official Full Name: serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 S homeolog
Primary source: Xenbase:XB-GENE-5804592
Locus tag: XELAEV_18041293mg
See related: EnsemblRapid:ENSXLAG00005003716 AllianceGenome:Xenbase:XB-GENE-5804592
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: a1a; a1at; alpha1AT; serpina1; serpina1d
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to act upstream of or within negative regulation of endopeptidase activity. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including alpha 1-antitrypsin deficiency; chronic obstructive pulmonary disease (multiple); human immunodeficiency virus infectious disease; inflammatory bowel disease (multiple); and liver disease (multiple). Orthologous to human SERPINA1 (serpin family A member 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 8S

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	8S	NC_054386.1 (20153701..20162618)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	8S	NC_030739.1 (20058412..20075177)

Chromosome 8S - NC_054386.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of endopeptidase activity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 S homeolog

Names: serine (or cysteine) proteinase inhibitor, clade A, member 1d

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001086802.2 → NP_001080271.1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 S homeolog precursor

See identical proteins and their annotated locations for NP_001080271.1

Status: PROVISIONAL

Source sequence(s)

BC054235

UniProtKB/TrEMBL

Q7SYX0

Related

ENSXLAP00005011074.1, ENSXLAT00005011248.1

Conserved Domains (1) summary

cd02056
Location:70 → 427

alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054386.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

20153701..20162618

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_018231859.2 → XP_018087348.1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 S homeolog isoform X1

UniProtKB/TrEMBL

A0A1L8F0C3, A0A974C266

Conserved Domains (1) summary

cd19548
Location:63 → 431

serpinA_A1AT-like; serpin family A member, alpha-1-antitrypsin and similar serpin proteins in birds and reptiles
XM_041574097.1 → XP_041430031.1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 S homeolog isoform X1

UniProtKB/TrEMBL

A0A1L8F0C3, A0A974C266

Conserved Domains (1) summary

cd19548
Location:63 → 431

serpinA_A1AT-like; serpin family A member, alpha-1-antitrypsin and similar serpin proteins in birds and reptiles
XM_041574099.1 → XP_041430033.1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 S homeolog isoform X1

UniProtKB/TrEMBL

A0A1L8F0C3, A0A974C266

Conserved Domains (1) summary

cd19548
Location:63 → 431

serpinA_A1AT-like; serpin family A member, alpha-1-antitrypsin and similar serpin proteins in birds and reptiles
XM_041574098.1 → XP_041430032.1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 S homeolog isoform X1

UniProtKB/TrEMBL

A0A1L8F0C3, A0A974C266

Conserved Domains (1) summary

cd19548
Location:63 → 431

serpinA_A1AT-like; serpin family A member, alpha-1-antitrypsin and similar serpin proteins in birds and reptiles