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pdia3 protein disulfide isomerase family A, member 3 [ Danio rerio (zebrafish) ]

Gene ID: 378851, updated on 17-Aug-2024

Summary

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Official Symbol
pdia3provided by ZNC
Official Full Name
protein disulfide isomerase family A, member 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-031002-9
See related
Ensembl:ENSDARG00000102640 AllianceGenome:ZFIN:ZDB-GENE-031002-9
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
Grp58; erp57; sb:cb825
Summary
Predicted to enable protein disulfide isomerase activity. Predicted to be involved in protein folding and response to endoplasmic reticulum stress. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in cell surface and endoplasmic reticulum. Is expressed in several structures, including axis; hatching gland; hypochord; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in autoimmune hepatitis. Orthologous to human PDIA3 (protein disulfide isomerase family A member 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See pdia3 in Genome Data Viewer
Location:
chromosome: 25
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (30343015..30357350, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (29900008..29914343, complement)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene alkB homolog 3, alpha-ketoglutarate dependent dioxygenase Neighboring gene si:ch1073-281m9.1 Neighboring gene TopBP1-interacting, checkpoint, and replication regulator Neighboring gene carboxylesterase 2b Neighboring gene transfer RNA arginine (anticodon ACG)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Calnexin is required for zebrafish posterior lateral line development. Hung IC, et al. Int J Dev Biol, 2013. PMID 23873374
  2. Gender-specific proteomic responses in zebrafish liver following exposure to a selected mixture of brominated flame retardants. Kling P, et al. Ecotoxicol Environ Saf, 2008 Oct. PMID 18258299
  3. A dynamic spatiotemporal extracellular matrix facilitates epicardial-mediated vertebrate heart regeneration. Mercer SE, et al. Dev Biol, 2013 Oct 15. PMID 23939298, Free PMC Article
  4. Epitranscriptomic m6A regulation following spinal cord injury. Xing L, et al. J Neurosci Res, 2021 Mar. PMID 33271625
  5. Responses of the Proteome and Metabolome in Livers of Zebrafish Exposed Chronically to Environmentally Relevant Concentrations of Microcystin-LR. Chen L, et al. Environ Sci Technol, 2017 Jan 3. PMID 28005350

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein disulfide isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein disulfide isomerase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to endoplasmic reticulum stress IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein disulfide-isomerase A3
Names
glucose regulated protein
NP_001186666.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199737.1 → NP_001186666.1  protein disulfide-isomerase A3 precursor

    Status: VALIDATED

    Source sequence(s)
    CU694321, EB857174, EH533119, FO907102
    UniProtKB/TrEMBL
    A0A8M1NXI0
    Related
    ENSDARP00000134643.1, ENSDART00000171137.2
    Conserved Domains (5) summary
    cd02995
    Location:367 → 470
    PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
    cd03069
    Location:125 → 230
    PDI_b_ERp57; PDIb family, ERp57 subfamily, first redox inactive TRX-like domain b; ERp57 (or ERp60) exhibits both disulfide oxidase and reductase functions like PDI, by catalyzing the formation of disulfide bonds of newly synthesized polypeptides in the ER and acting ...
    cd03073
    Location:234 → 347
    PDI_b'_ERp72_ERp57; PDIb' family, ERp72 and ERp57 subfamily, second redox inactive TRX-like domain b'; ERp72 and ER57 are involved in oxidative protein folding in the ER, like PDI. They exhibit both disulfide oxidase and reductase functions, by catalyzing the formation of ...
    TIGR01130
    Location:18 → 475
    ER_PDI_fam; protein disulfide isomerase, eukaryotic
    cl00388
    Location:19 → 116
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    30343015..30357350 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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