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KCP kielin cysteine rich BMP regulator [ Homo sapiens (human) ]

Gene ID: 375616, updated on 28-Oct-2024

Summary

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Official Symbol
KCPprovided by HGNC
Official Full Name
kielin cysteine rich BMP regulatorprovided by HGNC
Primary source
HGNC:HGNC:17585
See related
Ensembl:ENSG00000135253 MIM:609344; AllianceGenome:HGNC:17585
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KCP1; CRIM2; NET67
Summary
Predicted to be involved in positive regulation of BMP signaling pathway. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in extracellular space. Predicted to be active in extracellular region. [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in kidney (RPKM 3.0), fat (RPKM 0.8) and 8 other tissues See more
Orthologs
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Genomic context

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See KCP in Genome Data Viewer
Location:
7q32.1
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (128876865..128910709, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (130189791..130223635, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (128516919..128550763, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26605 Neighboring gene ATPase H+ transporting V1 subunit F Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18617 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18618 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18619 Neighboring gene sperm microtubule inner protein 1 Neighboring gene Sharpr-MPRA regulatory region 1680 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26607 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:128524773-128525372 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:128529996-128530586 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:128530587-128531176 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:128531177-128531767 Neighboring gene uncharacterized LOC105375497 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:128532717-128533916 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:128543906-128544411 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:128544412-128544916 Neighboring gene filamin C pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:128569307-128569807 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26608 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26609 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26610 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18620 Neighboring gene Sharpr-MPRA regulatory region 2205 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:128578271-128578854 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26611 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26612 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26613 Neighboring gene interferon regulatory factor 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Increased kielin/chordin-like protein levels are associated with the severity of heart failure. Ye J, et al. Clin Chim Acta, 2018 Nov. PMID 30144436
  2. Kielin/chordin-like protein enhances induction of osteoblast differentiation by Bone Morphogenetic Protein-2. Nagasaki K, et al. FEBS Open Bio, 2023 Jul. PMID 37226930, Free PMC Article
  3. Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease. Lin J, et al. Nat Med, 2005 Apr. PMID 15793581
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kielin/chordin-like protein enhances induction of osteoblast differentiation by Bone Morphogenetic Protein-2.
    Title: Kielin/chordin-like protein enhances induction of osteoblast differentiation by Bone Morphogenetic Protein-2.
  2. The KCP was closely associated with heart failure. The regulation of BMP2/7 and TGF-beta1 expression may be the possible mechanisms.
    Title: Increased kielin/chordin-like protein levels are associated with the severity of heart failure.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in positive regulation of BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
kielin/chordin-like protein
Names
cysteine rich BMP regulator 2 (chordin-like)
cysteine-rich motor neuron 2 protein
kielin/chordin-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001366122.1 → NP_001353051.1  kielin/chordin-like protein isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC025594, KF495713, KF510975
    Consensus CDS
    CCDS94194.1
    UniProtKB/Swiss-Prot
    A0A087WT73, Q6ZWJ8, Q8NBE0
    UniProtKB/TrEMBL
    A0A087WVT8
    Related
    ENSP00000479679.1, ENST00000610776.5
    Conserved Domains (5) summary
    pfam00093
    Location:138 → 188
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:1275 → 1424
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:1550 → 1603
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:1472 → 1539
    C8; C8 domain
    cl17735
    Location:1211 → 1268
    VWC; von Willebrand factor type C domain

  2. NM_199349.3 → NP_955381.2  kielin/chordin-like protein isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC025594, AK095464, AK122706
    UniProtKB/Swiss-Prot
    Q6ZWJ8
    Related
    ENST00000612224.1
    Conserved Domains (2) summary
    pfam00093
    Location:138 → 188
    VWC; von Willebrand factor type C domain
    cl17735
    Location:192 → 248
    VWC; von Willebrand factor type C domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    128876865..128910709 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    130189791..130223635 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001135914.1: Suppressed sequence

    Description
    NM_001135914.1: This RefSeq has been removed because currently there is insufficient support for the transcript and protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZWJ8.3 GenPept UniProtKB/Swiss-Prot:Q6ZWJ8

Gene LinkOut

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Chemical Information
Molecular Biology Databases
Research Materials