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Conserved domains on  [gi|209571521|ref|NP_955381|]
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kielin/chordin-like protein isoform 2 precursor [Homo sapiens]

Protein Classification

VWC domain-containing protein( domain architecture ID 10442377)

VWC domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 138-188 2.94e-07

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


:

Pssm-ID: 278520  Cd Length: 57  Bit Score: 47.80  E-value: 2.94e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 209571521  138 CSQNGQTYGNGETFSPDACTTCRCLEGTITCNQKPCPRGPCPEP------GACCPHC 188
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPrleippGECCPVC 57
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 192-248 6.38e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 41.26  E-value: 6.38e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 209571521  192 CDYEGQLYEEGVTFLSSsnPCLQCTCLRSRVRCMALKCPPSPCPEPVLR--PGHCCPTC 248
Cdd:pfam00093   1 CVQNGVVYENGETWKPD--LCTICTCDDGKVLCDKIICPPLDCPNPRLEipPGECCPVC 57
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 310-365 6.44e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 41.26  E-value: 6.44e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 209571521  310 CFLNGREHRSGEPVGSgDPCSHCRCANGSVQCEPLPCPPVPCRHPGKI--PGQCCPVC 365
Cdd:pfam00093   1 CVQNGVVYENGETWKP-DLCTICTCDDGKVLCDKIICPPLDCPNPRLEipPGECCPVC 57
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 424-480 2.27e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 39.72  E-value: 2.27e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 209571521  424 CELDGEEFAEGVQWEPDgrPCTACVCQDGVPKCGAVLCPPAPCQHPT--QPPGACCPSC 480
Cdd:pfam00093   1 CVQNGVVYENGETWKPD--LCTICTCDDGKVLCDKIICPPLDCPNPRleIPPGECCPVC 57
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 483-539 1.48e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member smart00214:

Pssm-ID: 450195  Cd Length: 59  Bit Score: 37.50  E-value: 1.48e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 209571521   483 CTYHSQVYANGQNFTDadSPCHACHCQDG-TVTCSLVDCPP-TTCARPQSG--PGQCCPRC 539
Cdd:smart00214   1 CVHNGRVYNDGETWKP--DPCQICTCLDGtTVLCDPVECPPpPDCPNPERVkpPGECCPRC 59
 
Name Accession Description Interval E-value
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 138-188 2.94e-07

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 47.80  E-value: 2.94e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 209571521  138 CSQNGQTYGNGETFSPDACTTCRCLEGTITCNQKPCPRGPCPEP------GACCPHC 188
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPrleippGECCPVC 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 192-248 6.38e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 41.26  E-value: 6.38e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 209571521  192 CDYEGQLYEEGVTFLSSsnPCLQCTCLRSRVRCMALKCPPSPCPEPVLR--PGHCCPTC 248
Cdd:pfam00093   1 CVQNGVVYENGETWKPD--LCTICTCDDGKVLCDKIICPPLDCPNPRLEipPGECCPVC 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 310-365 6.44e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 41.26  E-value: 6.44e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 209571521  310 CFLNGREHRSGEPVGSgDPCSHCRCANGSVQCEPLPCPPVPCRHPGKI--PGQCCPVC 365
Cdd:pfam00093   1 CVQNGVVYENGETWKP-DLCTICTCDDGKVLCDKIICPPLDCPNPRLEipPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
138-188 1.75e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 40.19  E-value: 1.75e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 209571521   138 CSQNGQTYGNGETFSPDACTTCRCLEG-TITCNQKPCPRGP-------CPEPGACCPHC 188
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGtTVLCDPVECPPPPdcpnperVKPPGECCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 424-480 2.27e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 39.72  E-value: 2.27e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 209571521  424 CELDGEEFAEGVQWEPDgrPCTACVCQDGVPKCGAVLCPPAPCQHPT--QPPGACCPSC 480
Cdd:pfam00093   1 CVQNGVVYENGETWKPD--LCTICTCDDGKVLCDKIICPPLDCPNPRleIPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
310-365 8.29e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 38.27  E-value: 8.29e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 209571521   310 CFLNGREHRSGEPVGSgDPCSHCRCANGS-VQCEPLPCPPVP-CRHPG--KIPGQCCPVC 365
Cdd:smart00214   1 CVHNGRVYNDGETWKP-DPCQICTCLDGTtVLCDPVECPPPPdCPNPErvKPPGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
424-480 1.48e-03

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 37.50  E-value: 1.48e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 209571521   424 CELDGEEFAEGVQWEPDgrPCTACVCQDGVP-KCGAVLCPPAP-CQHPT--QPPGACCPSC 480
Cdd:smart00214   1 CVHNGRVYNDGETWKPD--PCQICTCLDGTTvLCDPVECPPPPdCPNPErvKPPGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
483-539 1.48e-03

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 37.50  E-value: 1.48e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 209571521   483 CTYHSQVYANGQNFTDadSPCHACHCQDG-TVTCSLVDCPP-TTCARPQSG--PGQCCPRC 539
Cdd:smart00214   1 CVHNGRVYNDGETWKP--DPCQICTCLDGtTVLCDPVECPPpPDCPNPERVkpPGECCPRC 59
 
Name Accession Description Interval E-value
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 138-188 2.94e-07

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 47.80  E-value: 2.94e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 209571521  138 CSQNGQTYGNGETFSPDACTTCRCLEGTITCNQKPCPRGPCPEP------GACCPHC 188
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPrleippGECCPVC 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 192-248 6.38e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 41.26  E-value: 6.38e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 209571521  192 CDYEGQLYEEGVTFLSSsnPCLQCTCLRSRVRCMALKCPPSPCPEPVLR--PGHCCPTC 248
Cdd:pfam00093   1 CVQNGVVYENGETWKPD--LCTICTCDDGKVLCDKIICPPLDCPNPRLEipPGECCPVC 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 310-365 6.44e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 41.26  E-value: 6.44e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 209571521  310 CFLNGREHRSGEPVGSgDPCSHCRCANGSVQCEPLPCPPVPCRHPGKI--PGQCCPVC 365
Cdd:pfam00093   1 CVQNGVVYENGETWKP-DLCTICTCDDGKVLCDKIICPPLDCPNPRLEipPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
138-188 1.75e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 40.19  E-value: 1.75e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 209571521   138 CSQNGQTYGNGETFSPDACTTCRCLEG-TITCNQKPCPRGP-------CPEPGACCPHC 188
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGtTVLCDPVECPPPPdcpnperVKPPGECCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 424-480 2.27e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 39.72  E-value: 2.27e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 209571521  424 CELDGEEFAEGVQWEPDgrPCTACVCQDGVPKCGAVLCPPAPCQHPT--QPPGACCPSC 480
Cdd:pfam00093   1 CVQNGVVYENGETWKPD--LCTICTCDDGKVLCDKIICPPLDCPNPRleIPPGECCPVC 57
Amnionless pfam14828
Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for ...
 432-480 7.57e-04

Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.


Pssm-ID: 464340  Cd Length: 449  Bit Score: 42.76  E-value: 7.57e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 209571521  432 AEGVQWEPDGRP-CTACVCQDGV---PKCGAVL--CPPAPCQHPTQPPGACCPSC 480
Cdd:pfam14828 181 AGALRVGPEACSdPSGCGCGNDEnleRICANVLqrCPPPHCLSPLRPEGHCCDVC 235
VWC smart00214
von Willebrand factor (vWF) type C domain;
310-365 8.29e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 38.27  E-value: 8.29e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 209571521   310 CFLNGREHRSGEPVGSgDPCSHCRCANGS-VQCEPLPCPPVP-CRHPG--KIPGQCCPVC 365
Cdd:smart00214   1 CVHNGRVYNDGETWKP-DPCQICTCLDGTtVLCDPVECPPPPdCPNPErvKPPGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
424-480 1.48e-03

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 37.50  E-value: 1.48e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 209571521   424 CELDGEEFAEGVQWEPDgrPCTACVCQDGVP-KCGAVLCPPAP-CQHPT--QPPGACCPSC 480
Cdd:smart00214   1 CVHNGRVYNDGETWKPD--PCQICTCLDGTTvLCDPVECPPPPdCPNPErvKPPGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
483-539 1.48e-03

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 37.50  E-value: 1.48e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 209571521   483 CTYHSQVYANGQNFTDadSPCHACHCQDG-TVTCSLVDCPP-TTCARPQSG--PGQCCPRC 539
Cdd:smart00214   1 CVHNGRVYNDGETWKP--DPCQICTCLDGtTVLCDPVECPPpPDCPNPERVkpPGECCPRC 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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