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Cspp1 centrosome and spindle pole associated protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362472, updated on 28-Oct-2024

Summary

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Official Symbol
Cspp1provided by RGD
Official Full Name
centrosome and spindle pole associated protein 1provided by RGD
Primary source
RGD:1307055
See related
EnsemblRapid:ENSRNOG00000021718 AllianceGenome:RGD:1307055
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1307055
Summary
Predicted to be involved in positive regulation of cytokinesis. Predicted to be located in centriolar satellite and spindle. Predicted to be active in centrosome and spindle pole. Human ortholog(s) of this gene implicated in Joubert syndrome 21. Orthologous to human CSPP1 (centrosome and spindle pole associated protein 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Thymus (RPKM 89.2), Kidney (RPKM 76.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cspp1 in Genome Data Viewer
Location:
5q11
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (13860072..13975299, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (9077161..9192402, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (8761293..8876205, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ADP ribosylation factor guanine nucleotide exchange factor 1 Neighboring gene uncharacterized LOC134486914 Neighboring gene uncharacterized LOC134486913 Neighboring gene COP9 signalosome subunit 5 Neighboring gene RNA, U6 small nuclear 1297 Neighboring gene protein phosphatase 1, regulatory subunit 42

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Centrosome/spindle pole-associated protein regulates cytokinesis via promoting the recruitment of MyoGEF to the central spindle. Asiedu M, et al. Mol Biol Cell, 2009 Mar. PMID 19129481, Free PMC Article
  2. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in positive regulation of cell division ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centriolar satellite IEA
Inferred from Electronic Annotation
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in spindle ISO
Inferred from Sequence Orthology
more info
  
is_active_in spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
centrosome and spindle pole-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191864.2 → NP_001178793.2  centrosome and spindle pole-associated protein 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A8I5ZYD5, F1LPI1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    13860072..13975299 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039110193.1 → XP_038966121.1  centrosome and spindle pole-associated protein 1 isoform X15

    UniProtKB/TrEMBL
    A0A8I5ZYD5

  2. XM_039110190.2 → XP_038966118.1  centrosome and spindle pole-associated protein 1 isoform X14

    UniProtKB/TrEMBL
    A0A8I5ZYD5

  3. XM_039110189.2 → XP_038966117.1  centrosome and spindle pole-associated protein 1 isoform X13

    UniProtKB/TrEMBL
    A0A8I5ZYD5

  4. XM_063287886.1 → XP_063143956.1  centrosome and spindle pole-associated protein 1 isoform X20

  5. XM_039110201.2 → XP_038966129.1  centrosome and spindle pole-associated protein 1 isoform X34

    UniProtKB/TrEMBL
    A0A8I5ZYD5
    Conserved Domains (1) summary
    PTZ00108
    Location:54 → 405
    PTZ00108; DNA topoisomerase 2-like protein; Provisional

  6. XM_006237777.5 → XP_006237839.1  centrosome and spindle pole-associated protein 1 isoform X31

    UniProtKB/TrEMBL
    A0A8I5ZYD5
    Related
    ENSRNOP00000085024.2, ENSRNOT00000097155.2
    Conserved Domains (1) summary
    PTZ00108
    Location:54 → 405
    PTZ00108; DNA topoisomerase 2-like protein; Provisional

  7. XM_039110186.2 → XP_038966114.1  centrosome and spindle pole-associated protein 1 isoform X10

    UniProtKB/TrEMBL
    A0A8I5ZYD5
    Conserved Domains (1) summary
    PTZ00108
    Location:54 → 405
    PTZ00108; DNA topoisomerase 2-like protein; Provisional

  8. XM_039110184.2 → XP_038966112.1  centrosome and spindle pole-associated protein 1 isoform X9

    UniProtKB/TrEMBL
    A0A8I5ZYD5
    Conserved Domains (1) summary
    PTZ00108
    Location:54 → 406
    PTZ00108; DNA topoisomerase 2-like protein; Provisional

  9. XM_039110200.2 → XP_038966128.1  centrosome and spindle pole-associated protein 1 isoform X33

    UniProtKB/TrEMBL
    A0A8I6A987
    Conserved Domains (1) summary
    PTZ00108
    Location:54 → 432
    PTZ00108; DNA topoisomerase 2-like protein; Provisional

  10. XM_039110182.2 → XP_038966110.1  centrosome and spindle pole-associated protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A8I6A987
    Conserved Domains (1) summary
    PTZ00108
    Location:54 → 432
    PTZ00108; DNA topoisomerase 2-like protein; Provisional

  11. XM_063287881.1 → XP_063143951.1  centrosome and spindle pole-associated protein 1 isoform X8

    Related
    ENSRNOP00000081772.2, ENSRNOT00000099294.2

  12. XM_039110181.2 → XP_038966109.1  centrosome and spindle pole-associated protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8I6A987
    Conserved Domains (1) summary
    PTZ00108
    Location:54 → 433
    PTZ00108; DNA topoisomerase 2-like protein; Provisional

  13. XM_063287885.1 → XP_063143955.1  centrosome and spindle pole-associated protein 1 isoform X19

  14. XM_006237778.5 → XP_006237840.1  centrosome and spindle pole-associated protein 1 isoform X32

    UniProtKB/TrEMBL
    A0A8I6A987

  15. XM_063287880.1 → XP_063143950.1  centrosome and spindle pole-associated protein 1 isoform X7

  16. XM_006237775.5 → XP_006237837.1  centrosome and spindle pole-associated protein 1 isoform X30

    UniProtKB/TrEMBL
    A0A8I6A987

  17. XM_039110179.2 → XP_038966107.1  centrosome and spindle pole-associated protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A987

  18. XM_006237774.5 → XP_006237836.1  centrosome and spindle pole-associated protein 1 isoform X18

    UniProtKB/TrEMBL
    A0A8I6A987

  19. XM_006237767.5 → XP_006237829.1  centrosome and spindle pole-associated protein 1 isoform X12

    UniProtKB/TrEMBL
    A0A8I6A987
    Related
    ENSRNOP00000095654.2, ENSRNOT00000112751.2

  20. XM_006237763.5 → XP_006237825.1  centrosome and spindle pole-associated protein 1 isoform X6

    See identical proteins and their annotated locations for XP_006237825.1

    UniProtKB/TrEMBL
    A0A8I5ZTS7, A0A8I6A987

  21. XM_039110187.2 → XP_038966115.1  centrosome and spindle pole-associated protein 1 isoform X11

    UniProtKB/TrEMBL
    A0A8I6A987

  22. XM_039110180.2 → XP_038966108.1  centrosome and spindle pole-associated protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I6A987

  23. XM_039110178.2 → XP_038966106.1  centrosome and spindle pole-associated protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZYG0, A0A8I6A987
    Related
    ENSRNOP00000008480.8, ENSRNOT00000008480.8

  24. XM_063287888.1 → XP_063143958.1  centrosome and spindle pole-associated protein 1 isoform X22

  25. XM_063287883.1 → XP_063143953.1  centrosome and spindle pole-associated protein 1 isoform X17

  26. XM_063287882.1 → XP_063143952.1  centrosome and spindle pole-associated protein 1 isoform X16

    UniProtKB/TrEMBL
    A0A8I6AK55

  27. XM_039110192.2 → XP_038966120.1  centrosome and spindle pole-associated protein 1 isoform X15

    UniProtKB/TrEMBL
    A0A8I5ZYD5

  28. XM_063287887.1 → XP_063143957.1  centrosome and spindle pole-associated protein 1 isoform X21

  29. XM_039110194.2 → XP_038966122.1  centrosome and spindle pole-associated protein 1 isoform X15

    UniProtKB/TrEMBL
    A0A8I5ZYD5

  30. XM_063287893.1 → XP_063143963.1  centrosome and spindle pole-associated protein 1 isoform X28

  31. XM_063287890.1 → XP_063143960.1  centrosome and spindle pole-associated protein 1 isoform X25

  32. XM_063287889.1 → XP_063143959.1  centrosome and spindle pole-associated protein 1 isoform X24

  33. XM_063287891.1 → XP_063143961.1  centrosome and spindle pole-associated protein 1 isoform X26

  34. XM_039110195.2 → XP_038966123.1  centrosome and spindle pole-associated protein 1 isoform X23

  35. XM_063287892.1 → XP_063143962.1  centrosome and spindle pole-associated protein 1 isoform X27

  36. XM_039110198.2 → XP_038966126.1  centrosome and spindle pole-associated protein 1 isoform X29

RNA

  1. XR_005504467.2 RNA Sequence

  2. XR_010066406.1 RNA Sequence

  3. XR_005504468.2 RNA Sequence

  4. XR_005504470.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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