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Conserved domains on  [gi|1958777021|ref|XP_038966110|]
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centrosome and spindle pole-associated protein 1 isoform X5 [Rattus norvegicus]

Protein Classification

DNA topoisomerase 2-like domain-containing protein( domain architecture ID 1000163)

DNA topoisomerase 2-like domain-containing protein; DNA topoisomerase 2 alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTZ00108 super family cl36510
DNA topoisomerase 2-like protein; Provisional
 54-432 9.52e-04

DNA topoisomerase 2-like protein; Provisional


The actual alignment was detected with superfamily member PTZ00108:

Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 43.88  E-value: 9.52e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777021   54 RNKLFGILNVSRET--EVIYRMadGLDEFIEEQKVKLAQDKAELESDlpymemKGKASEKLSENSKILISMAKEnippns 131
Cdd:PTZ00108  1022 INGELVITNAKKKDlvKELKKL--GYVRFKDIIKKKSEKITAEEEEG------AEEDDEADDEDDEEELGAAVS------ 1087

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777021  132 qqpkgslgIDYGLSLPLGEDYEQKKHKLKEELRQDYRRYLTQKNflstgeTDPSTLGvslpigdrlsakerlklerNREY 211
Cdd:PTZ00108  1088 --------YDYLLSMPIWSLTKEKVEKLNAELEKKEKELEKLKN------TTPKDMW-------------------LEDL 1134

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777021  212 NQFlrgkEESTEKVRQVERNIEAKSQRNKNPVSQGKSDLPSQALTSYAHSEGPAHEELLNQRQREEGRYRQLDDGIELRT 291
Cdd:PTZ00108  1135 DKF----EEALEEQEEVEEKEIAKEQRLKSKTKGKASKLRKPKLKKKEKKKKKSSADKSKKASVVGNSKRVDSDEKRKLD 1210

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777021  292 RRPLKQTNEEIGISGTSHQSFSSKTAAPerracrfNEERVLDKQYCRADRDPDISEDMDDRFRFESDFDRKFLRV----- 366
Cdd:PTZ00108  1211 DKPDNKKSNSSGSDQEDDEEQKTKPKKS-------SVKRLKSKKNNSSKSSEDNDEFSSDDLSKEGKPKNAPKRVsavqy 1283

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958777021  367 ---YTNDRPHGSRQCADEEGVSEEPKTQISEEPKTQISEEPKTQISCAENKSVRDNGPPKCADVNVTSP 432
Cdd:PTZ00108  1284 sppPPSKRPDGESNGGSKPSSPTKKKVKKRLEGSLAALKKKKKSEKKTARKKKSKTRVKQASASQSSRL 1352
 
Name Accession Description Interval E-value
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 54-432 9.52e-04

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 43.88  E-value: 9.52e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777021   54 RNKLFGILNVSRET--EVIYRMadGLDEFIEEQKVKLAQDKAELESDlpymemKGKASEKLSENSKILISMAKEnippns 131
Cdd:PTZ00108  1022 INGELVITNAKKKDlvKELKKL--GYVRFKDIIKKKSEKITAEEEEG------AEEDDEADDEDDEEELGAAVS------ 1087

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777021  132 qqpkgslgIDYGLSLPLGEDYEQKKHKLKEELRQDYRRYLTQKNflstgeTDPSTLGvslpigdrlsakerlklerNREY 211
Cdd:PTZ00108  1088 --------YDYLLSMPIWSLTKEKVEKLNAELEKKEKELEKLKN------TTPKDMW-------------------LEDL 1134

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777021  212 NQFlrgkEESTEKVRQVERNIEAKSQRNKNPVSQGKSDLPSQALTSYAHSEGPAHEELLNQRQREEGRYRQLDDGIELRT 291
Cdd:PTZ00108  1135 DKF----EEALEEQEEVEEKEIAKEQRLKSKTKGKASKLRKPKLKKKEKKKKKSSADKSKKASVVGNSKRVDSDEKRKLD 1210

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777021  292 RRPLKQTNEEIGISGTSHQSFSSKTAAPerracrfNEERVLDKQYCRADRDPDISEDMDDRFRFESDFDRKFLRV----- 366
Cdd:PTZ00108  1211 DKPDNKKSNSSGSDQEDDEEQKTKPKKS-------SVKRLKSKKNNSSKSSEDNDEFSSDDLSKEGKPKNAPKRVsavqy 1283

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958777021  367 ---YTNDRPHGSRQCADEEGVSEEPKTQISEEPKTQISEEPKTQISCAENKSVRDNGPPKCADVNVTSP 432
Cdd:PTZ00108  1284 sppPPSKRPDGESNGGSKPSSPTKKKVKKRLEGSLAALKKKKKSEKKTARKKKSKTRVKQASASQSSRL 1352
 
Name Accession Description Interval E-value
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 54-432 9.52e-04

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 43.88  E-value: 9.52e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777021   54 RNKLFGILNVSRET--EVIYRMadGLDEFIEEQKVKLAQDKAELESDlpymemKGKASEKLSENSKILISMAKEnippns 131
Cdd:PTZ00108  1022 INGELVITNAKKKDlvKELKKL--GYVRFKDIIKKKSEKITAEEEEG------AEEDDEADDEDDEEELGAAVS------ 1087

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777021  132 qqpkgslgIDYGLSLPLGEDYEQKKHKLKEELRQDYRRYLTQKNflstgeTDPSTLGvslpigdrlsakerlklerNREY 211
Cdd:PTZ00108  1088 --------YDYLLSMPIWSLTKEKVEKLNAELEKKEKELEKLKN------TTPKDMW-------------------LEDL 1134

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777021  212 NQFlrgkEESTEKVRQVERNIEAKSQRNKNPVSQGKSDLPSQALTSYAHSEGPAHEELLNQRQREEGRYRQLDDGIELRT 291
Cdd:PTZ00108  1135 DKF----EEALEEQEEVEEKEIAKEQRLKSKTKGKASKLRKPKLKKKEKKKKKSSADKSKKASVVGNSKRVDSDEKRKLD 1210

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958777021  292 RRPLKQTNEEIGISGTSHQSFSSKTAAPerracrfNEERVLDKQYCRADRDPDISEDMDDRFRFESDFDRKFLRV----- 366
Cdd:PTZ00108  1211 DKPDNKKSNSSGSDQEDDEEQKTKPKKS-------SVKRLKSKKNNSSKSSEDNDEFSSDDLSKEGKPKNAPKRVsavqy 1283

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958777021  367 ---YTNDRPHGSRQCADEEGVSEEPKTQISEEPKTQISEEPKTQISCAENKSVRDNGPPKCADVNVTSP 432
Cdd:PTZ00108  1284 sppPPSKRPDGESNGGSKPSSPTKKKVKKRLEGSLAALKKKKKSEKKTARKKKSKTRVKQASASQSSRL 1352
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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