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Aen apoptosis enhancing nuclease [ Rattus norvegicus (Norway rat) ]

Gene ID: 361594, updated on 17-Aug-2024

Summary

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Official Symbol
Aenprovided by RGD
Official Full Name
apoptosis enhancing nucleaseprovided by RGD
Primary source
RGD:1305051
See related
EnsemblRapid:ENSRNOG00000018421 AllianceGenome:RGD:1305051
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Isg20l1; RGD1305051
Summary
Predicted to enable exonuclease activity. Predicted to be involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and response to ionizing radiation. Predicted to be located in nuclear membrane; nucleolus; and nucleoplasm. Predicted to be active in nucleus. Orthologous to human AEN (apoptosis enhancing nuclease). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 75.3), Spleen (RPKM 69.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q31
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (142224499..142233902)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (132815094..132824522)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (140584328..140593749)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120099862 Neighboring gene uncharacterized LOC120099863 Neighboring gene microRNA 8 Neighboring gene interferon stimulated exonuclease gene 20 Neighboring gene uncharacterized LOC102547609

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of a novel ionizing radiation-induced nuclease, AEN, and its functional characterization in apoptosis. Lee JH, et al. Biochem Biophys Res Commun, 2005 Nov 11. PMID 16171785
  2. p53 target gene AEN is a nuclear exonuclease required for p53-dependent apoptosis. Kawase T, et al. Oncogene, 2008 Jun 19. PMID 18264133
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA exonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables exonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables exonuclease activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
Inferred from Sequence Orthology
more info
  
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
  
involved_in response to ionizing radiation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
apoptosis-enhancing nuclease
Names
interferon stimulated exonuclease gene 20-like 1
interferon-stimulated 20 kDa exonuclease-like 1
NP_001101957.1
XP_006229461.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108487.2 → NP_001101957.1  apoptosis-enhancing nuclease

    See identical proteins and their annotated locations for NP_001101957.1

    Status: PROVISIONAL

    Source sequence(s)
    BC166435
    UniProtKB/Swiss-Prot
    B2GUW6
    Related
    ENSRNOP00000062841.1, ENSRNOT00000064438.3
    Conserved Domains (2) summary
    COG0847
    Location:102 → 263
    DnaQ; DNA polymerase III, epsilon subunit or related 3'-5' exonuclease [Replication, recombination and repair]
    cl10012
    Location:106 → 262
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    142224499..142233902
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006229399.5 → XP_006229461.1  apoptosis-enhancing nuclease isoform X1

    See identical proteins and their annotated locations for XP_006229461.1

    UniProtKB/Swiss-Prot
    B2GUW6
    Conserved Domains (2) summary
    COG0847
    Location:102 → 263
    DnaQ; DNA polymerase III, epsilon subunit or related 3'-5' exonuclease [Replication, recombination and repair]
    cl10012
    Location:106 → 262
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B2GUW6.1 GenPept UniProtKB/Swiss-Prot:B2GUW6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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