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ath athos [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34357, updated on 18-Sep-2024

Summary

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Official Symbol
athprovided by FlyBase
Official Full Name
athosprovided by FlyBase
Primary source
FLYBASE:FBgn0032194
Locus tag
Dmel_CG4901
See related
AllianceGenome:FB:FBgn0032194
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cg4901; CG4901; Dmel\CG4901
Summary
Predicted to enable RNA binding activity and RNA helicase activity. Predicted to be involved in positive regulation of transcription by RNA polymerase I. Predicted to be active in nucleolus. Is expressed in several structures, including anterior endoderm; embryonic/larval muscle system; extended germ band embryo; foregut primordium; and gut section. Orthologous to human DHX33 (DEAH-box helicase 33). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See ath in Genome Data Viewer
Location:
31B1-31B1; 2-40 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10211143..10213721)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10211170..10213721)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44845 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Niemann-Pick type C-1a Neighboring gene Proteasome alpha6 subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A translation control module coordinates germline stem cell differentiation with ribosome biogenesis during Drosophila oogenesis. Martin ET, et al. Dev Cell, 2022 Apr 11. PMID 35413237, Free PMC Article
  2. Tracing the origin of the compensasome: evolutionary history of DEAH helicase and MYST acetyltransferase gene families. Sanjuán R, et al. Mol Biol Evol, 2001 Mar. PMID 11230534
  3. Misexpression screen delineates novel genes controlling Drosophila lifespan. Paik D, et al. Mech Ageing Dev, 2012 May. PMID 22366109, Free PMC Article
  4. p53 directs focused genomic responses in Drosophila. Akdemir F, et al. Oncogene, 2007 Aug 9. PMID 17310982
  5. The genetic basis for variation in resistance to infection in the Drosophila melanogaster genetic reference panel. Wang JB, et al. PLoS Pathog, 2017 Mar. PMID 28257468, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables rRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase I IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosome biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
athos
Names
CG4901-PA
CG4901-PB
CG4901-PC
ath-PA
ath-PB
ath-PC
NP_001334733.1
NP_001334734.1
NP_609356.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    10211143..10213721
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001347806.1 → NP_001334734.1  athos, isoform C [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MYY2, Q9VL25

  2. NM_001347805.1 → NP_001334733.1  athos, isoform B [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MYY2, Q9VL25

  3. NM_135512.4 → NP_609356.2  athos, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609356.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MYY2, Q9VL25
    Related
    FBpp0079537
    Conserved Domains (5) summary
    smart00847
    Location:469 → 554
    HA2; Helicase associated domain (HA2) Add an annotation
    COG1643
    Location:23 → 691
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    cd00046
    Location:87 → 228
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00271
    Location:280 → 401
    Helicase_C; Helicase conserved C-terminal domain
    pfam07717
    Location:603 → 688
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VL25.2 Q9VL25

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