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prkab1b protein kinase, AMP-activated, beta 1 non-catalytic subunit, b [ Danio rerio (zebrafish) ]

Gene ID: 335232, updated on 2-Nov-2024

Summary

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Official Symbol
prkab1bprovided by ZNC
Official Full Name
protein kinase, AMP-activated, beta 1 non-catalytic subunit, bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-7172
See related
Ensembl:ENSDARG00000046143 AllianceGenome:ZFIN:ZDB-GENE-030131-7172
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
prkab1; zgc:56652; zgc:76975; wu:fk93d05; wu:fw87e09
Summary
Predicted to enable protein kinase binding activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within lipid metabolic process and phosphorylation. Predicted to be part of nucleotide-activated protein kinase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human PRKAB1 (protein kinase AMP-activated non-catalytic subunit beta 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See prkab1b in Genome Data Viewer
Location:
chromosome: 8
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (39674707..39703747)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (39640933..39669973)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene si:dkey-63d15.12 Neighboring gene transmembrane protein 233 Neighboring gene phospholipase A2, group IB (pancreas) Neighboring gene asialoglycoprotein receptor-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Loss of Wnt16 Leads to Skeletal Deformities and Downregulation of Bone Developmental Pathway in Zebrafish. Qu X, et al. Int J Mol Sci, 2021 Jun 22. PMID 34206401, Free PMC Article
  2. Anti-Hypoxic Molecular Mechanisms of Rhodiola crenulata Extract in Zebrafish as Revealed by Metabonomics. Ma Y, et al. Front Pharmacol, 2019. PMID 31780949, Free PMC Article
  3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nucleotide-activated protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
5'-AMP-activated protein kinase subunit beta-1b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001328554.1 → NP_001315483.1  5'-AMP-activated protein kinase subunit beta-1b

    Status: VALIDATED

    Source sequence(s)
    BX005328, EH456078, EH461046, EH508306
    UniProtKB/TrEMBL
    A0A8M1PAF8, Q6NY31
    Related
    ENSDARP00000107882.2, ENSDART00000126301.4
    Conserved Domains (2) summary
    smart01010
    Location:171 → 260
    AMPKBI; 5'-AMP-activated protein kinase beta subunit, interation domain
    pfam16561
    Location:68 → 151
    AMPK1_CBM; Glycogen recognition site of AMP-activated protein kinase

  2. NM_214713.2 → NP_999878.1  5'-AMP-activated protein kinase subunit beta-1b

    See identical proteins and their annotated locations for NP_999878.1

    Status: VALIDATED

    Source sequence(s)
    BX005328, EH456078, EH461046, EH508306
    UniProtKB/TrEMBL
    A0A8M1PAF8, Q6NY31
    Related
    ENSDARP00000040329.5, ENSDART00000040330.7
    Conserved Domains (2) summary
    smart01010
    Location:171 → 260
    AMPKBI; 5'-AMP-activated protein kinase beta subunit, interation domain
    pfam16561
    Location:68 → 151
    AMPK1_CBM; Glycogen recognition site of AMP-activated protein kinase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    39674707..39703747
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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