NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1038986235|ref|NP_001315483|]
View 

5'-AMP-activated protein kinase subunit beta-1b [Danio rerio]

Protein Classification

protein kinase subunit beta( domain architecture ID 11244030)

protein kinase subunit beta is a non-catalytic subunit of a protein kinase, such as Saccharomyces cerevisiae SNF1 protein kinase subunits beta-2 and beta-3, and human 5'-AMP-activated protein kinase subunits beta-1 and beta-2

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
AMPK1_CBM pfam16561
Glycogen recognition site of AMP-activated protein kinase; AMPK1_CBM is a family found in ...
 67-151 4.63e-47

Glycogen recognition site of AMP-activated protein kinase; AMPK1_CBM is a family found in close association with AMPKBI pfam04739. The surface of AMPK1_CBM reveals a carbohydrate-binding pocket.


:

Pssm-ID: 465176 [Multi-domain]  Cd Length: 85  Bit Score: 151.53  E-value: 4.63e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038986235  67 RPTVFRWKGPGKEIYLSGSFNNWATKIPLNKSHNNFVAIIDLPEGEHQYKFYVDGHWTLDPKEPVVTNKSGVVNNVIKVR 146
Cdd:pfam16561   1 VPTVITWRGGGKKVYVTGSFDNWKKKIPLQKSGGDFTTILDLPPGTHQYKFIVDGEWRHDPDLPTATDDMGNLNNYIEVK 80


                  ....*
gi 1038986235 147 KTDFE 151
Cdd:pfam16561  81 ASDFE 85
AMPKBI smart01010
5'-AMP-activated protein kinase beta subunit, interation domain; This region is found in the ...
 171-260 3.92e-42

5'-AMP-activated protein kinase beta subunit, interation domain; This region is found in the beta subunit of the 5'-AMP-activated protein kinase complex, and its yeast homologues Sip1, Sip2 and Gal83, which are found in the SNF1 kinase complex. This region is sufficient for interaction of this subunit with the kinase complex, but is not solely responsible for the interaction, and the interaction partner is not known. The isoamylase N-terminal domain is sometimes found in proteins belonging to this family.


:

Pssm-ID: 214973  Cd Length: 100  Bit Score: 139.38  E-value: 3.92e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038986235  171 SSPPGPYHQDPYST---------KSEDKLRSPPILPPHLLQVLLNK-DTGISCDPTLLPEPNHVMLNHLYALSIKDGVMV 240
Cdd:smart01010   1 QSPPESYTNEIPACftdddfieeSPEEKWKEPPALPPHLEKVILNTsSTATREDPSLLPIPNHVVLNHLYTSSIKDGVLA 80

                           90       100
                   ....*....|....*....|
gi 1038986235  241 LSATHRYKKKYVTTLLYKPI 260
Cdd:smart01010  81 VAATTRYRGKYVTQVLYKPL 100
 
Name Accession Description Interval E-value
AMPK1_CBM pfam16561
Glycogen recognition site of AMP-activated protein kinase; AMPK1_CBM is a family found in ...
 67-151 4.63e-47

Glycogen recognition site of AMP-activated protein kinase; AMPK1_CBM is a family found in close association with AMPKBI pfam04739. The surface of AMPK1_CBM reveals a carbohydrate-binding pocket.


Pssm-ID: 465176 [Multi-domain]  Cd Length: 85  Bit Score: 151.53  E-value: 4.63e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038986235  67 RPTVFRWKGPGKEIYLSGSFNNWATKIPLNKSHNNFVAIIDLPEGEHQYKFYVDGHWTLDPKEPVVTNKSGVVNNVIKVR 146
Cdd:pfam16561   1 VPTVITWRGGGKKVYVTGSFDNWKKKIPLQKSGGDFTTILDLPPGTHQYKFIVDGEWRHDPDLPTATDDMGNLNNYIEVK 80


                  ....*
gi 1038986235 147 KTDFE 151
Cdd:pfam16561  81 ASDFE 85
AMPKBI smart01010
5'-AMP-activated protein kinase beta subunit, interation domain; This region is found in the ...
 171-260 3.92e-42

5'-AMP-activated protein kinase beta subunit, interation domain; This region is found in the beta subunit of the 5'-AMP-activated protein kinase complex, and its yeast homologues Sip1, Sip2 and Gal83, which are found in the SNF1 kinase complex. This region is sufficient for interaction of this subunit with the kinase complex, but is not solely responsible for the interaction, and the interaction partner is not known. The isoamylase N-terminal domain is sometimes found in proteins belonging to this family.


Pssm-ID: 214973  Cd Length: 100  Bit Score: 139.38  E-value: 3.92e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038986235  171 SSPPGPYHQDPYST---------KSEDKLRSPPILPPHLLQVLLNK-DTGISCDPTLLPEPNHVMLNHLYALSIKDGVMV 240
Cdd:smart01010   1 QSPPESYTNEIPACftdddfieeSPEEKWKEPPALPPHLEKVILNTsSTATREDPSLLPIPNHVVLNHLYTSSIKDGVLA 80

                           90       100
                   ....*....|....*....|
gi 1038986235  241 LSATHRYKKKYVTTLLYKPI 260
Cdd:smart01010  81 VAATTRYRGKYVTQVLYKPL 100
AMPKBI pfam04739
5'-AMP-activated protein kinase beta subunit, interaction domain; This region is found in the ...
 190-259 1.48e-41

5'-AMP-activated protein kinase beta subunit, interaction domain; This region is found in the beta subunit of the 5'-AMP-activated protein kinase complex, and its yeast homologs Sip1, Sip2 and Gal83, which are found in the SNF1 kinase complex. This region is sufficient for interaction of this subunit with the kinase complex, but is not solely responsible for the interaction, and the interaction partner is not known. The isoamylase N-terminal domain (pfam02922) is sometimes found in proteins belonging to this family.


Pssm-ID: 461416  Cd Length: 70  Bit Score: 136.90  E-value: 1.48e-41
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038986235 190 LRSPPILPPHLLQVLLNKDTGISCDPTLLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKP 259
Cdd:pfam04739   1 AKEPPALPPHLHLTILNKPSSSSDDPSLLPRPNHVVLNHLYTSSIKDGVLALGTTHRYKSKYVTTVLYKP 70
E_set_AMPKbeta_like_N cd02859
N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain ...
 68-145 1.35e-35

N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; E or "early" set domains are associated with the catalytic domain of AMP-activated protein kinase beta subunit glycogen binding domain at the N-terminal end. AMPK is a metabolic stress sensing protein that senses AMP/ATP and has recently been found to act as a glycogen sensor as well. The protein functions as an alpha-beta-gamma heterotrimer. This N-terminal domain is the glycogen binding domain of the beta subunit. This domain is also a member of the CBM48 (Carbohydrate Binding Module 48) family whose members include pullulanase, maltooligosyl trehalose synthase, starch branching enzyme, glycogen branching enzyme, glycogen debranching enzyme, and isoamylase.


Pssm-ID: 199889 [Multi-domain]  Cd Length: 80  Bit Score: 121.94  E-value: 1.35e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038986235  68 PTVFRWKGP-GKEIYLSGSFNNWATKIPLNKSHNN-FVAIIDLPEGEHQYKFYVDGHWTLDPKEPVVTNKSGVVNNVIKV 145
Cdd:cd02859     1 PVTFRWPGPgGKEVYVTGSFDNWQQPIPLEKSGDGeFSATVELPPGRYEYKFIVDGEWVHDPDLPTVTDEFGNLNNVLEV 80
 
Name Accession Description Interval E-value
AMPK1_CBM pfam16561
Glycogen recognition site of AMP-activated protein kinase; AMPK1_CBM is a family found in ...
 67-151 4.63e-47

Glycogen recognition site of AMP-activated protein kinase; AMPK1_CBM is a family found in close association with AMPKBI pfam04739. The surface of AMPK1_CBM reveals a carbohydrate-binding pocket.


Pssm-ID: 465176 [Multi-domain]  Cd Length: 85  Bit Score: 151.53  E-value: 4.63e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038986235  67 RPTVFRWKGPGKEIYLSGSFNNWATKIPLNKSHNNFVAIIDLPEGEHQYKFYVDGHWTLDPKEPVVTNKSGVVNNVIKVR 146
Cdd:pfam16561   1 VPTVITWRGGGKKVYVTGSFDNWKKKIPLQKSGGDFTTILDLPPGTHQYKFIVDGEWRHDPDLPTATDDMGNLNNYIEVK 80


                  ....*
gi 1038986235 147 KTDFE 151
Cdd:pfam16561  81 ASDFE 85
AMPKBI smart01010
5'-AMP-activated protein kinase beta subunit, interation domain; This region is found in the ...
 171-260 3.92e-42

5'-AMP-activated protein kinase beta subunit, interation domain; This region is found in the beta subunit of the 5'-AMP-activated protein kinase complex, and its yeast homologues Sip1, Sip2 and Gal83, which are found in the SNF1 kinase complex. This region is sufficient for interaction of this subunit with the kinase complex, but is not solely responsible for the interaction, and the interaction partner is not known. The isoamylase N-terminal domain is sometimes found in proteins belonging to this family.


Pssm-ID: 214973  Cd Length: 100  Bit Score: 139.38  E-value: 3.92e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038986235  171 SSPPGPYHQDPYST---------KSEDKLRSPPILPPHLLQVLLNK-DTGISCDPTLLPEPNHVMLNHLYALSIKDGVMV 240
Cdd:smart01010   1 QSPPESYTNEIPACftdddfieeSPEEKWKEPPALPPHLEKVILNTsSTATREDPSLLPIPNHVVLNHLYTSSIKDGVLA 80

                           90       100
                   ....*....|....*....|
gi 1038986235  241 LSATHRYKKKYVTTLLYKPI 260
Cdd:smart01010  81 VAATTRYRGKYVTQVLYKPL 100
AMPKBI pfam04739
5'-AMP-activated protein kinase beta subunit, interaction domain; This region is found in the ...
 190-259 1.48e-41

5'-AMP-activated protein kinase beta subunit, interaction domain; This region is found in the beta subunit of the 5'-AMP-activated protein kinase complex, and its yeast homologs Sip1, Sip2 and Gal83, which are found in the SNF1 kinase complex. This region is sufficient for interaction of this subunit with the kinase complex, but is not solely responsible for the interaction, and the interaction partner is not known. The isoamylase N-terminal domain (pfam02922) is sometimes found in proteins belonging to this family.


Pssm-ID: 461416  Cd Length: 70  Bit Score: 136.90  E-value: 1.48e-41
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038986235 190 LRSPPILPPHLLQVLLNKDTGISCDPTLLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKP 259
Cdd:pfam04739   1 AKEPPALPPHLHLTILNKPSSSSDDPSLLPRPNHVVLNHLYTSSIKDGVLALGTTHRYKSKYVTTVLYKP 70
E_set_AMPKbeta_like_N cd02859
N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain ...
 68-145 1.35e-35

N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; E or "early" set domains are associated with the catalytic domain of AMP-activated protein kinase beta subunit glycogen binding domain at the N-terminal end. AMPK is a metabolic stress sensing protein that senses AMP/ATP and has recently been found to act as a glycogen sensor as well. The protein functions as an alpha-beta-gamma heterotrimer. This N-terminal domain is the glycogen binding domain of the beta subunit. This domain is also a member of the CBM48 (Carbohydrate Binding Module 48) family whose members include pullulanase, maltooligosyl trehalose synthase, starch branching enzyme, glycogen branching enzyme, glycogen debranching enzyme, and isoamylase.


Pssm-ID: 199889 [Multi-domain]  Cd Length: 80  Bit Score: 121.94  E-value: 1.35e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038986235  68 PTVFRWKGP-GKEIYLSGSFNNWATKIPLNKSHNN-FVAIIDLPEGEHQYKFYVDGHWTLDPKEPVVTNKSGVVNNVIKV 145
Cdd:cd02859     1 PVTFRWPGPgGKEVYVTGSFDNWQQPIPLEKSGDGeFSATVELPPGRYEYKFIVDGEWVHDPDLPTVTDEFGNLNNVLEV 80
E_set_Isoamylase_like_N cd07184
N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also ...
 76-145 2.58e-10

N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; E or "early" set domains are associated with the catalytic domain of isoamylase-like proteins at the N-terminal end. Isoamylase is one of the starch-debranching enzymes that catalyze the hydrolysis of alpha-1,6-glucosidic linkages specific in alpha-glucans such as amylopectin or glycogen. Isoamylase contains a bound calcium ion, but this is not in the same position as the conserved calcium ion that has been reported in other alpha-amylase family enzymes. The N-terminal domain of isoamylase may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end and may be involved in homodimeric/tetrameric/dodecameric interactions. Members of this family include members of the alpha amylase family, sialidase, galactose oxidase, cellulase, cellulose, hyaluronate lyase, chitobiase, and chitinase. This domain is also a member of the CBM48 (Carbohydrate Binding Module 48) family whose members include pullulanase, maltooligosyl trehalose synthase, starch branching enzyme, glycogen branching enzyme, glycogen debranching enzyme, and the beta subunit of AMP-activated protein kinase.


Pssm-ID: 199892 [Multi-domain]  Cd Length: 86  Bit Score: 55.71  E-value: 2.58e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1038986235  76 PGKEIYLSGSFNNWATK-IPLNKSHNN-FVAIIDLPEG-EHQYKFYVDGH-WTLDPKEPV-VTNKSGVVNNVIKV 145
Cdd:cd07184    12 GADSVSLVGDFNDWDPQaTPMKKLKNGtFSATLDLPAGrEYQFRYLIDGErWVNDPEADAyAPNGFGEENSVVSV 86
E_set cd02688
Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the ...
 68-143 1.30e-09

Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; The E or "early" set domains of sugar utilizing enzymes are associated with different types of catalytic domains at either the N-terminal or C-terminal end. These domains may be related to the immunoglobulin and/or fibronectin type III superfamilies. Members of this family include alpha amylase, sialidase, galactose oxidase, cellulase, cellulose, hyaluronate lyase, chitobiase, and chitinase. A subset of these members were recently identified as members of the CBM48 (Carbohydrate Binding Module 48) family. Members of the CBM48 family include pullulanase, maltooligosyl trehalose synthase, starch branching enzyme, glycogen branching enzyme, glycogen debranching enzyme, isoamylase, and the beta subunit of AMP-activated protein kinase.


Pssm-ID: 199878 [Multi-domain]  Cd Length: 82  Bit Score: 53.70  E-value: 1.30e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1038986235  68 PTVFRWKGPG-KEIYLSGSFNNWATKIPL---NKSHNNFVAIIDLPEGEHQYKFYVDGHWTLDPKE--PVVTNKSGVVNN 141
Cdd:cd02688     1 GVTFRIFAPGaKSVYLIGSFNGWWQAQALpmtKNGGGVWSATIPLPLGTYEYKYVIDGGKNVLPYFdpYYVAGDGNSGAS 80


                  ..
gi 1038986235 142 VI 143
Cdd:cd02688    81 IV 82
E_set_GBE_prok_N cd02855
N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen ...
 78-127 2.20e-04

N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; This subfamily is composed of predominantly prokaryotic 1,4 alpha glucan branching enzymes, also called glycogen branching enzymes. E or "early" set domains are associated with the catalytic domain of glycogen branching enzymes at the N-terminal end. Glycogen branching enzyme catalyzes the formation of alpha-1,6 branch points in either glycogen or starch by cleavage of the alpha-1,4 glucosidic linkage, yielding a non-reducing end oligosaccharide chain, as well as the subsequent attachment of short glucosyl chains to the alpha-1,6 position. By increasing the number of non-reducing ends, glycogen is more reactive to synthesis and digestion as well as being more soluble. The N-terminal domain of the 1,4 alpha glucan branching enzyme may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end and may be involved in homodimeric/tetrameric/dodecameric interactions. Members of this family include members of the alpha amylase family, sialidase, galactose oxidase, cellulase, cellulose, hyaluronate lyase, chitobiase, and chitinase, among others.


Pssm-ID: 199885 [Multi-domain]  Cd Length: 105  Bit Score: 39.40  E-value: 2.20e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1038986235  78 KEIYLSGSFNNW-ATKIPLNKSHNN-----FVAiiDLPEGEHqYKFYV---DGHWTL--DP 127
Cdd:cd02855    31 KRVSVVGDFNDWdGRAHPMRRIGDSgvwelFIP--GAKEGDL-YKYEIetaDGEVLLkaDP 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH