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CG33514 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3346239, updated on 18-Sep-2024

Summary

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Official Symbol
CG33514provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0053514
Locus tag
Dmel_CG33514
See related
AllianceGenome:FB:FBgn0053514
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG15017; CG15018; Dmel\CG33514
Summary
Predicted to enable lipid transfer activity and phosphatidylinositol bisphosphate binding activity. Predicted to be involved in intermembrane lipid transfer. Predicted to be located in late endosome. Is expressed in adult head. Human ortholog(s) of this gene implicated in familial isolated deficiency of vitamin E. Orthologous to human TTPA (alpha tocopherol transfer protein) and TTPAL (alpha tocopherol transfer protein like). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See CG33514 in Genome Data Viewer
Location:
64B2-64B2; 3-12 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4365434..4366671)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4365434..4366671)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Cdc42-interacting protein 4 Neighboring gene long non-coding RNA:CR45156 Neighboring gene mitochondrial ribosomal protein S6 Neighboring gene uncharacterized protein Neighboring gene Dopamine/Ecdysteroid receptor Neighboring gene long non-coding RNA:CR44360 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The requirement of IRE1 and XBP1 in resolving physiological stress during Drosophila development. Huang HW, et al. J Cell Sci, 2017 Sep 15. PMID 28775151, Free PMC Article
  2. Abdominal-B neurons control Drosophila virgin female receptivity. Bussell JJ, et al. Curr Biol, 2014 Jul 21. PMID 24998527, Free PMC Article
  3. dusky-like is required to maintain the integrity and planar cell polarity of hairs during the development of the Drosophila wing. Adler PN, et al. Dev Biol, 2013 Jul 1. PMID 23623898, Free PMC Article
  4. Prospero acts as a binary switch between self-renewal and differentiation in Drosophila neural stem cells. Choksi SP, et al. Dev Cell, 2006 Dec. PMID 17141154
  5. Genome-wide analysis of self-renewal in Drosophila neural stem cells by transgenic RNAi. Neumüller RA, et al. Cell Stem Cell, 2011 May 6. PMID 21549331, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables lipid transfer activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidylinositol bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol bisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in intermembrane lipid transfer ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in late endosome ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG33514-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    4365434..4366671
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001014558.3 → NP_001014558.1  uncharacterized protein Dmel_CG33514 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014558.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NLM7
    Conserved Domains (2) summary
    smart01100
    Location:28 → 74
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    cd00170
    Location:97 → 253
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NLM7 Q6NLM7

Gene LinkOut

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