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Cdh18 cadherin 18 [ Mus musculus (house mouse) ]

Gene ID: 320865, updated on 2-Nov-2024

Summary

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Official Symbol
Cdh18provided by MGI
Official Full Name
cadherin 18provided by MGI
Primary source
MGI:MGI:1344366
See related
Ensembl:ENSMUSG00000040420 AllianceGenome:MGI:1344366
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cdh14l; B230220E17Rik; Tg(GFAP-APOE_i4)1Hol
Summary
Predicted to enable beta-catenin binding activity and cadherin binding activity. Predicted to be involved in several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell-cell adhesion mediated by cadherin; and cell-cell junction organization. Predicted to be part of catenin complex. Predicted to be active in adherens junction. Is expressed in several structures, including central nervous system; eye; and testis. Orthologous to human CDH18 (cadherin 18). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cerebellum adult (RPKM 8.0), cortex adult (RPKM 2.6) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Cdh18 in Genome Data Viewer
Location:
15 A2; 15 8.54 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (22548984..23477577)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (22548898..23477491)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene cadherin 12 Neighboring gene STARR-seq mESC enhancer starr_38121 Neighboring gene STARR-seq mESC enhancer starr_38122 Neighboring gene STARR-seq mESC enhancer starr_38123 Neighboring gene STARR-seq mESC enhancer starr_38124 Neighboring gene predicted gene, 25101 Neighboring gene STARR-seq mESC enhancer starr_38125 Neighboring gene STARR-seq mESC enhancer starr_38126 Neighboring gene STARR-seq mESC enhancer starr_38127 Neighboring gene STARR-seq mESC enhancer starr_38128 Neighboring gene STARR-seq mESC enhancer starr_38129 Neighboring gene STARR-seq mESC enhancer starr_38132 Neighboring gene STARR-seq mESC enhancer starr_38133 Neighboring gene STARR-seq mESC enhancer starr_38134 Neighboring gene STARR-seq mESC enhancer starr_38135 Neighboring gene predicted gene, 41278 Neighboring gene heterogeneous nuclear ribonucleoprotein A1-like 2, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_38138 Neighboring gene STARR-seq mESC enhancer starr_38139 Neighboring gene STARR-seq mESC enhancer starr_38140 Neighboring gene STARR-seq mESC enhancer starr_38141 Neighboring gene STARR-seq mESC enhancer starr_38142 Neighboring gene STARR-seq mESC enhancer starr_38144 Neighboring gene STARR-seq mESC enhancer starr_38145 Neighboring gene predicted gene, 19840 Neighboring gene STARR-seq mESC enhancer starr_38147 Neighboring gene STARR-seq mESC enhancer starr_38148 Neighboring gene predicted gene, 24656 Neighboring gene STARR-seq mESC enhancer starr_38149 Neighboring gene predicted gene 6533 Neighboring gene predicted gene, 23980

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Role of Impaired Receptor Trafficking in Mediating the Pathological Effects of APOE4 in Alzheimer's Disease. Safieh M, et al. J Alzheimers Dis, 2024. PMID 38217595, Free PMC Article
  2. Apolipoprotein E 4 triggers multiple pathway-mediated Ca2+ overload, causes CaMK II phosphorylation abnormity and aggravates oxidative stress caused cerebral cortical neuron damage. Xu D, et al. Eur Rev Med Pharmacol Sci, 2017 Dec. PMID 29272008
  3. Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins. Sun Y, et al. J Neurosci, 1998 May 1. PMID 9547235, Free PMC Article
  4. Multiple cadherin mRNA expression and developmental regulation of a novel cadherin in the developing mouse eye. Faulkner-Jones BE, et al. Exp Neurol, 1999 Apr. PMID 10328938
  5. Expression of human apolipoprotein E downregulates amyloid precursor protein-induced ischemic susceptibility. Koistinaho M, et al. Stroke, 2002 Jul. PMID 12105373

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Role of Impaired Receptor Trafficking in Mediating the Pathological Effects of APOE4 in Alzheimer's Disease.
    Title: The Role of Impaired Receptor Trafficking in Mediating the Pathological Effects of APOE4 in Alzheimer's Disease.
  2. The Rhox gene cluster suppresses germline LINE1 transposition.
    Title: The Rhox gene cluster suppresses germline LINE1 transposition.
  3. APOE triggers Ca2+ overload through NMDAR and CaMK II signaling pathway, both of which cause Ca2+ concentration increasing, CaMK II phosphorylation abnormity, and finally aggravate oxidative stress damaged neurons apoptosis
    Title: Apolipoprotein E 4 triggers multiple pathway-mediated Ca2+ overload, causes CaMK II phosphorylation abnormity and aggravates oxidative stress caused cerebral cortical neuron damage.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Transgenic (1)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cadherin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in adherens junction organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion mediated by cadherin IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catenin complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cadherin-18
Names
GFAP-apoE4 line1
Tg(GFAP-APOE*4)1Hol
Tg(GFAP-APOE4)1Hol

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081299.1 → NP_001074768.1  cadherin-18 precursor

    See identical proteins and their annotated locations for NP_001074768.1

    Status: VALIDATED

    Source sequence(s)
    AC121357, AC134595, AC134864, AC157478
    Consensus CDS
    CCDS49585.1
    UniProtKB/TrEMBL
    E9Q9Q6
    Related
    ENSMUSP00000130851.2, ENSMUST00000164787.8
    Conserved Domains (3) summary
    cd11304
    Location:387 → 484
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:79 → 157
    CA; Cadherin repeats
    pfam01049
    Location:637 → 783
    Cadherin_C; Cadherin cytoplasmic region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    22548984..23477577
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520095.4 → XP_006520158.1  cadherin-18 isoform X1

    See identical proteins and their annotated locations for XP_006520158.1

    UniProtKB/TrEMBL
    E9Q9Q6
    Conserved Domains (3) summary
    cd11304
    Location:387 → 484
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:79 → 157
    CA; Cadherin repeats
    pfam01049
    Location:637 → 783
    Cadherin_C; Cadherin cytoplasmic region

  2. XM_006520096.5 → XP_006520159.1  cadherin-18 isoform X1

    See identical proteins and their annotated locations for XP_006520159.1

    UniProtKB/TrEMBL
    E9Q9Q6
    Conserved Domains (3) summary
    cd11304
    Location:387 → 484
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:79 → 157
    CA; Cadherin repeats
    pfam01049
    Location:637 → 783
    Cadherin_C; Cadherin cytoplasmic region

  3. XM_011245360.4 → XP_011243662.1  cadherin-18 isoform X1

    See identical proteins and their annotated locations for XP_011243662.1

    UniProtKB/TrEMBL
    E9Q9Q6
    Conserved Domains (3) summary
    cd11304
    Location:387 → 484
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:79 → 157
    CA; Cadherin repeats
    pfam01049
    Location:637 → 783
    Cadherin_C; Cadherin cytoplasmic region

  4. XM_006520094.5 → XP_006520157.1  cadherin-18 isoform X1

    See identical proteins and their annotated locations for XP_006520157.1

    UniProtKB/TrEMBL
    E9Q9Q6
    Conserved Domains (3) summary
    cd11304
    Location:387 → 484
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:79 → 157
    CA; Cadherin repeats
    pfam01049
    Location:637 → 783
    Cadherin_C; Cadherin cytoplasmic region

  5. XM_036159468.1 → XP_036015361.1  cadherin-18 isoform X1

    UniProtKB/TrEMBL
    E9Q9Q6
    Conserved Domains (3) summary
    cd11304
    Location:387 → 484
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:79 → 157
    CA; Cadherin repeats
    pfam01049
    Location:637 → 783
    Cadherin_C; Cadherin cytoplasmic region

  6. XM_030248609.2 → XP_030104469.1  cadherin-18 isoform X3

    UniProtKB/TrEMBL
    E9Q941
    Related
    ENSMUSP00000128643.2, ENSMUST00000165614.9
    Conserved Domains (2) summary
    cd11304
    Location:387 → 484
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:79 → 157
    CA; Cadherin repeats

  7. XM_030248608.2 → XP_030104468.1  cadherin-18 isoform X2

    UniProtKB/TrEMBL
    A0A2I3BPS8
    Related
    ENSMUSP00000153905.2, ENSMUST00000226693.2
    Conserved Domains (2) summary
    cd11304
    Location:387 → 484
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:79 → 157
    CA; Cadherin repeats

  8. XM_030248607.2 → XP_030104467.1  cadherin-18 isoform X1

    UniProtKB/TrEMBL
    E9Q9Q6
    Conserved Domains (3) summary
    cd11304
    Location:387 → 484
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:79 → 157
    CA; Cadherin repeats
    pfam01049
    Location:637 → 783
    Cadherin_C; Cadherin cytoplasmic region
Nucleotide Protein Strain
Heading Accession and Version

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