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Fsd1l fibronectin type III and SPRY domain containing 1-like [ Mus musculus (house mouse) ]

Gene ID: 319636, updated on 2-Nov-2024

Summary

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Official Symbol
Fsd1lprovided by MGI
Official Full Name
fibronectin type III and SPRY domain containing 1-likeprovided by MGI
Primary source
MGI:MGI:2442443
See related
Ensembl:ENSMUSG00000054752 AllianceGenome:MGI:2442443
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ccdc10; Fsd1nl; Csdufd1; A230072O16Rik
Summary
Orthologous to human FSD1L (fibronectin type III and SPRY domain containing 1 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E18 (RPKM 4.1), whole brain E14.5 (RPKM 4.0) and 16 other tissues See more
Orthologs
human all
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Genomic context

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See Fsd1l in Genome Data Viewer
Location:
4 B2; 4 28.72 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (53631383..53707009)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (53631383..53707009)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 44, member 1 Neighboring gene RIKEN cDNA 1700060J05 gene Neighboring gene predicted gene, 54226 Neighboring gene single stranded DNA binding protein 4 pseudogene Neighboring gene fukutin Neighboring gene T cell acute lymphocytic leukemia 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
FSD1-like protein
Names
FSD1 N-terminal-like protein
coiled-coil domain-containing protein 10
cystatin and DUF19 domain containing 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195284.1 → NP_001182213.1  FSD1-like protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). This variant lacks full-length support in mouse; it is predicted based on partial mouse and full-length human transcript alignments from GeneID:83856.
    Source sequence(s)
    AL807745, BB626514, BB662298, CJ115006, CJ261972
    Consensus CDS
    CCDS57276.1
    UniProtKB/TrEMBL
    E0CXZ1
    Related
    ENSMUSP00000114931.2, ENSMUST00000132151.8
    Conserved Domains (3) summary
    cd00063
    Location:165 → 265
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12901
    Location:270 → 473
    SPRY_PRY_FSD1; Fibronectin type III and SPRY containing 1 (FSD1) domain includes PRY at the N-terminus
    cl23765
    Location:4 → 130
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  2. NM_001355377.1 → NP_001342306.1  FSD1-like protein isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (3) has the same N- and C-termini, but is one aa shorter than isoform 1.
    Source sequence(s)
    AK052914, AL807745, BB626514, CJ115006, CJ261972
    UniProtKB/TrEMBL
    E0CXZ1
    Related
    ENSMUSP00000124613.3, ENSMUST00000163067.9
    Conserved Domains (3) summary
    cd00063
    Location:165 → 265
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12901
    Location:270 → 472
    SPRY_PRY_FSD1; Fibronectin type III and SPRY containing 1 (FSD1) domain includes PRY at the N-terminus
    cl25407
    Location:4 → 130
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

  3. NM_001369182.1 → NP_001356111.1  FSD1-like protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL807745
    Conserved Domains (2) summary
    cd00063
    Location:52 → 140
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12901
    Location:145 → 348
    SPRY_PRY_FSD1; Fibronectin type III and SPRY containing 1 (FSD1) domain includes PRY at the N-terminus

  4. NM_176966.4 → NP_795940.1  FSD1-like protein isoform 2

    See identical proteins and their annotated locations for NP_795940.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several 3' exons and differs in its 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is significantly shorter than isoform 1.
    Source sequence(s)
    AL807745, BC130265
    UniProtKB/TrEMBL
    A1L3T0
    Related
    ENSMUST00000107643.8
    Conserved Domains (1) summary
    cl23765
    Location:4 → 113
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    53631383..53707009
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537980.4 → XP_006538043.1  FSD1-like protein isoform X1

    UniProtKB/Swiss-Prot
    Q3USW7, Q8BYN5
    Related
    ENSMUSP00000124002.3, ENSMUST00000159415.9
    Conserved Domains (3) summary
    smart00502
    Location:4 → 130
    BBC; B-Box C-terminal domain
    cd00063
    Location:165 → 265
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12901
    Location:270 → 484
    SPRY_PRY_FSD1; Fibronectin type III and SPRY containing 1 (FSD1) domain includes PRY at the N-terminus

  2. XM_036164182.1 → XP_036020075.1  FSD1-like protein isoform X3

    Conserved Domains (2) summary
    cd00063
    Location:52 → 140
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12901
    Location:145 → 359
    SPRY_PRY_FSD1; Fibronectin type III and SPRY containing 1 (FSD1) domain includes PRY at the N-terminus

  3. XM_036164183.1 → XP_036020076.1  FSD1-like protein isoform X4

    Conserved Domains (2) summary
    cd00063
    Location:2 → 78
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12901
    Location:83 → 297
    SPRY_PRY_FSD1; Fibronectin type III and SPRY containing 1 (FSD1) domain includes PRY at the N-terminus

  4. XM_017320255.3 → XP_017175744.1  FSD1-like protein isoform X2

    Conserved Domains (2) summary
    cd00063
    Location:94 → 182
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12901
    Location:187 → 401
    SPRY_PRY_FSD1; Fibronectin type III and SPRY containing 1 (FSD1) domain includes PRY at the N-terminus

RNA

  1. XR_004941920.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BYN5.2 GenPept UniProtKB/Swiss-Prot:Q8BYN5

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