Conserved Protein Domain Family
SPRY_PRY_FSD1
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cd12901: SPRY_PRY_FSD1 
Fibronectin type III and SPRY containing 1 (FSD1) domain includes PRY at the N-terminus
This domain is part of the fibronectin type III and SPRY domain containing 1 (FSD1) and FSD1-like (FSD1L) proteins. These are centrosome-associated proteins that are characterized by an N-terminal coiled-coil region downstream of B-box (BBC) domain, a central fibronectin type III (FN3) domain, and C-terminal repeats in PRY/SPRY domain. The FSD1 protein associates with a subset of microtubules and may be involved in the stability and organization of microtubules during cytokinesis.
Links
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Statistics
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PSSM-Id: 293958
Aligned: 9 rows
Threshold Bit Score: 384.564
Created: 22-Jun-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9BXM9       302 FNLDNSSSHLNLKVEDT--CVEWDPTGGkgq---esKIKGKENKGRsgtpspkrtsv------gsrppavrgsRDRFTGE 370 human
EEN48688     137 FKLDQTSCHANLKVTEDgsSVEWDAMGGkgq---lqETKGRGSRPGspaktvrpaspak--spakrpasaskrGDRFTGE 211 Florida lancelet
Q1LY10       270 FKLDASSSHQNLKVEDL--SVEWDSSGGkvavqdirKEKNRTNSPMhspartamms-------pkrapsarvgRDRFTAE 340 zebrafish
XP_424884    270 FDLDNTSSHVNLKVEDS--YVEWEPTGGrg----qeKVKGKENKSRsgaspkrtsi--------ggkapvkgsRDRFAGE 335 chicken
NP_001107516 271 FRLDAGSSHQNLRVEES--NVEWDATGGkv-----qDIKNREKDGRgrgaspcnsparc-vqspkrmpsarvgRDRFTAE 342 western clawed ...
XP_001340260 270 FSFDSSSSHLNLKVEEQ--SVEWDPQAGkal---dsKGKGKENKGRsgtpspkrts-------vtrspaprgaRDRFTGE 337 zebrafish
KFR04843     263 FRLDASTCHQNLRVEEL--SVEWDATGGkv-----qDVKAREKDGKgrtaspansparv-vqspkrmpsgrggRDRFTAE 334 crested ibis
NP_077309    270 FRLDASTSHQNLRVDDL--SVEWDAMGGkv-----qDIKAREKDGKgrtaspinsparg-tpspkrmpsgrggRDRFTAE 341 human
XP_005999127 270 FKLDSGTSHQNLKVEDL--NVEWDAMGGkv-----qDIKAREKDGKsrtaspvhsparcvmqspkripmgrsnRDRFTAE 342 coelacanth

Q9BXM9       371 SYTVLGDtaIEsGQHYWEVKAQKDCKSYSVGVAYKTLGKFDQLGKTNTSWCIHVNNWLQNTFAAKHNNKVKALDvTVPeK 450 human
EEN48688     212 SYTVLADvtLDeGQHYWEVTAQPECKSFTLGVAYRNLGKFDQLGKTNTSWCLHVNNWLQNTMSAKHNNKSKQLDvSIPeR 291 Florida lancelet
Q1LY10       341 SYTVLGDtmIDaGQHYWEVRFDKESKAFAAGVALRSLGRFDQLGKSNASWCIHLNNWLQQSLTAKHNNKARTLDcSIPdR 420 zebrafish
XP_424884    336 SYTVLGNnaIEsGQHYWEVRAQKDCKSYSVGVAYKTLGKYDQLGKTNISWCIHVNNWLQNTLAAKHNNKTKTLDmPVPdR 415 chicken
NP_001107516 343 SYTVLGDtpIDgGDCYWEVRFDKDSKAFAVGVTYRSLGKFDQLGKTSVSWCLHLNNWLQVTFAAKHGNKARILDvAVPnR 422 western clawed ...
XP_001340260 338 SYTVLGDtsIEsGQHYWEVKPQKDCKSYSVGLAYRNLGKFDQLGKTCTSWCIHVNNWLQNSFAAKHNNKAKNLDvPVPdS 417 zebrafish
KFR04843     335 SYTVLGDtlIDgDDHYWEVRYDRDSKAFGVGVAYRSLGKFDQLGKTSASWCLHLNNWLQVSFSAKHANKAKVLDvPVPdC 414 crested ibis
NP_077309    342 SYTVLGDtlIDgGEHYWEVRYEPDSKAFGVGVAYRSLGRFEQLGKTAASWCLHVNNWLQVSFTAKHANKVKVLDaPVPdC 421 human
XP_005999127 343 SYTVLGDtlIDgGQQYWEVKYDKDSKAFSVGVAYRSLGKFDQLGKTSASWCLYLNNWLQVSFTAKHNNKAKILDvVVPdR 422 coelacanth

Q9BXM9       451 IGVFCDFdgGQLSFYDAnsKQLLYSFKTKFTQPVLPGFMVWcGGLSLSTGMQVPS 505 human
EEN48688     292 IGVYLDYdnLVLSFHDAetKQLLHQFKAKFQQPVLPAFMTWcGGLTVQTGLRVNG 346 Florida lancelet
Q1LY10       421 IGIYCNYeeGTLSFYNSrnKTLLHTFRTKFQQPVIPAFMVWnGSFSVQTGLQVPS 475 zebrafish
XP_424884    416 LGVYCNFdgGQLTFYNAisKVPLYTFRMKFTQPLLPAFMIRcGGLAVSTGLQVPS 470 chicken
NP_001107516 423 IGVHCSYeeGFLSFYNAtnKQLLHTFRMKFTQPVLPAFMVWcGSFSVYTGLQVPS 477 western clawed frog
XP_001340260 418 IGVYCDFdrGQLAFYNAenKQLLHMFKMKFTQPVVPAFMVWcGGLILSTGLQVPS 472 zebrafish
KFR04843     415 IGVYCNFheGFLSFYNArtKQLLHTFKAKFTQPVLPAFTVWcGSFHVSSGLQVPS 469 crested ibis
NP_077309    422 LGVHCDFhqGLLSFYNArtKQVLHTFKTRFTQPLLPAFTVWcGSFQVTTGLQVPS 476 human
XP_005999127 423 IGVYCNYeeGHLAFYNAttKQLLHSFKVKFTQPVLPAFMAS-FLYELSTNLLYED 476 coelacanth
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