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Ptpmeg2 Protein tyrosine phosphatase Meg2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31907, updated on 18-Sep-2024

Summary

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Official Symbol
Ptpmeg2provided by FlyBase
Official Full Name
Protein tyrosine phosphatase Meg2provided by FlyBase
Primary source
FLYBASE:FBgn0028341
Locus tag
Dmel_CG32697
See related
AllianceGenome:FB:FBgn0028341
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3101; CG3102; CG32697; dMeg2; Dmel\CG32697; l(1)G0232; L(1)G0232; lG0232; MEG2; PTP-Meg2
Summary
Enables non-membrane spanning protein tyrosine phosphatase activity. Involved in border follicle cell migration and peptidyl-tyrosine phosphorylation. Located in cytosol. Is expressed in adult brain and adult head. Orthologous to human PTPN9 (protein tyrosine phosphatase non-receptor type 9). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See Ptpmeg2 in Genome Data Viewer
Location:
8F2-8F6; 1-29 cM
Exon count:
15
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9626294..9659145, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9520327..9553178, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Lysyl-tRNA synthetase Neighboring gene Hecw ubiquitin protein ligase Neighboring gene uncharacterized protein Neighboring gene nejire Neighboring gene long non-coding RNA:CR42657

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PTPN9-mediated dephosphorylation of VTI1B promotes ATG16L1 precursor fusion and autophagosome formation. Chou HY, et al. Autophagy, 2021 Oct. PMID 33112705, Free PMC Article
  2. MetaBlasts: tracing protein tyrosine phosphatase gene family roots from Man to Drosophila melanogaster and Caenorhabditis elegans genomes. Wälchli S, et al. Gene, 2000 Aug 8. PMID 10940550
  3. Design of RNA splicing analysis null models for post hoc filtering of Drosophila head RNA-Seq data with the splicing analysis kit (Spanki). Sturgill D, et al. BMC Bioinformatics, 2013 Nov 9. PMID 24209455, Free PMC Article
  4. The Bro1-domain-containing protein Myopic/HDPTP coordinates with Rab4 to regulate cell adhesion and migration. Chen DY, et al. J Cell Sci, 2012 Oct 15. PMID 22825871
  5. Cis-regulatory variation is typically polyallelic in Drosophila. Gruber JD, et al. Genetics, 2009 Feb. PMID 19064705, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables non-membrane spanning protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in border follicle cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol HDA PubMed 

General protein information

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Preferred Names
protein tyrosine phosphatase Meg2
Names
CG32697-PA
CG32697-PB
CG32697-PC
CG32697-PD
CG32697-PE
CG32697-PF
CG32697-PG
CG32697-PH
CG32697-PI
Ptpmeg2-PA
Ptpmeg2-PB
Ptpmeg2-PC
Ptpmeg2-PD
Ptpmeg2-PE
Ptpmeg2-PF
Ptpmeg2-PG
Ptpmeg2-PH
Ptpmeg2-PI
lethal (1) G0232
NP_001014728.1
NP_001014729.1
NP_001188573.1
NP_001188574.1
NP_001259386.1
NP_572576.1
NP_727356.1
NP_727357.1
NP_727358.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    9626294..9659145 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167199.4 → NP_727358.1  protein tyrosine phosphatase Meg2, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727358.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IRM6
    Related
    FBpp0099557
    Conserved Domains (2) summary
    cd00047
    Location:230 → 474
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam00102
    Location:228 → 474
    Y_phosphatase; Protein-tyrosine phosphatase

  2. NM_001014728.4 → NP_001014728.1  protein tyrosine phosphatase Meg2, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014728.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q59E68
    Conserved Domains (3) summary
    cd00047
    Location:329 → 573
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00170
    Location:1 → 84
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
    pfam00102
    Location:327 → 573
    Y_phosphatase; Protein-tyrosine phosphatase

  3. NM_001201644.3 → NP_001188573.1  protein tyrosine phosphatase Meg2, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188573.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9MS42
    Conserved Domains (4) summary
    smart01100
    Location:77 → 107
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    cd00047
    Location:522 → 766
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00170
    Location:133 → 277
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
    pfam00102
    Location:520 → 766
    Y_phosphatase; Protein-tyrosine phosphatase

  4. NM_167197.3 → NP_727356.1  protein tyrosine phosphatase Meg2, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727356.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IRM7
    Related
    FBpp0099556
    Conserved Domains (4) summary
    smart01100
    Location:84 → 114
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    cd00047
    Location:529 → 773
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00170
    Location:140 → 284
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
    pfam00102
    Location:527 → 773
    Y_phosphatase; Protein-tyrosine phosphatase

  5. NM_132348.3 → NP_572576.1  protein tyrosine phosphatase Meg2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572576.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q960Z9, Q9W323
    Related
    FBpp0099554
    Conserved Domains (4) summary
    smart01100
    Location:114 → 144
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    cd00047
    Location:559 → 803
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00170
    Location:170 → 314
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
    pfam00102
    Location:557 → 803
    Y_phosphatase; Protein-tyrosine phosphatase

  6. NM_167198.2 → NP_727357.1  protein tyrosine phosphatase Meg2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727357.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W324
    Related
    FBpp0099555
    Conserved Domains (4) summary
    smart01100
    Location:89 → 119
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    cd00047
    Location:534 → 778
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00170
    Location:145 → 289
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
    pfam00102
    Location:532 → 778
    Y_phosphatase; Protein-tyrosine phosphatase

  7. NM_001272457.1 → NP_001259386.1  protein tyrosine phosphatase Meg2, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259386.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IRM6
    Conserved Domains (2) summary
    cd00047
    Location:230 → 474
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam00102
    Location:228 → 474
    Y_phosphatase; Protein-tyrosine phosphatase

  8. NM_001014729.3 → NP_001014729.1  protein tyrosine phosphatase Meg2, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014729.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IRM6
    Conserved Domains (2) summary
    cd00047
    Location:230 → 474
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam00102
    Location:228 → 474
    Y_phosphatase; Protein-tyrosine phosphatase

  9. NM_001201645.2 → NP_001188574.1  protein tyrosine phosphatase Meg2, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188574.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IRM6
    Conserved Domains (2) summary
    cd00047
    Location:230 → 474
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam00102
    Location:228 → 474
    Y_phosphatase; Protein-tyrosine phosphatase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9MS42 M9MS42
Q59E68 Q59E68
Q8IRM6 Q8IRM6
Q8IRM7 Q8IRM7
Q9W323 Q9W323
Q9W324 Q9W324

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