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Cfp1 CXXC finger protein 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31880, updated on 18-Sep-2024

Summary

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Official Symbol
Cfp1provided by FlyBase
Official Full Name
CXXC finger protein 1provided by FlyBase
Primary source
FLYBASE:FBgn0030121
Locus tag
Dmel_CG17446
See related
AllianceGenome:FB:FBgn0030121
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG17446; CXXC1; dCfp1; dCXXC1; Dmel\CG17446
Summary
Predicted to enable DNA binding activity and zinc ion binding activity. Involved in histone H3-K4 methylation. Part of Set1C/COMPASS complex. Orthologous to human CXXC1 (CXXC finger protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See Cfp1 in Genome Data Viewer
Location:
8D4-8D4; 1-27 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9270434..9272960, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9164467..9166993, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Extracellularly regulated kinase 7 Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene aladin Neighboring gene c11.1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic Signatures of Drug Response Variability in Drosophila melanogaster. Rohde PD, et al. Genetics, 2019 Oct. PMID 31455722, Free PMC Article
  2. The genetic basis and adult reproductive consequences of developmental thermal plasticity. Rodrigues LR, et al. J Anim Ecol, 2022 Jun. PMID 35060127, Free PMC Article
  3. The COMPASS family of H3K4 methylases in Drosophila. Mohan M, et al. Mol Cell Biol, 2011 Nov. PMID 21875999, Free PMC Article
  4. COMPASS and SWI/SNF complexes in development and disease. Cenik BK, et al. Nat Rev Genet, 2021 Jan. PMID 32958894
  5. Drosophila Set1 is the major histone H3 lysine 4 trimethyltransferase with role in transcription. Ardehali MB, et al. EMBO J, 2011 Jun 21. PMID 21694722, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Set1C/COMPASS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Set1C/COMPASS complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Set1C/COMPASS complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CXXC finger protein 1
Names
CG17446-PA
CG17446-PB
Cfp1-PA
Cfp1-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    9270434..9272960 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001201641.2 → NP_001188570.1  CXXC finger protein 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188570.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9MS35
    Conserved Domains (3) summary
    pfam02008
    Location:158 → 198
    zf-CXXC; CXXC zinc finger domain
    cd15553
    Location:42 → 87
    PHD_Cfp1; PHD finger found in CXXC-type zinc finger protein 1 (Cfp1)
    pfam12269
    Location:280 → 512
    zf-CpG_bind_C; CpG binding protein zinc finger C terminal domain

  2. NM_132328.3 → NP_572556.1  CXXC finger protein 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572556.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9W352
    Related
    FBpp0071262
    Conserved Domains (3) summary
    pfam02008
    Location:178 → 218
    zf-CXXC; CXXC zinc finger domain
    cd15553
    Location:62 → 107
    PHD_Cfp1; PHD finger found in CXXC-type zinc finger protein 1 (Cfp1)
    pfam12269
    Location:300 → 532
    zf-CpG_bind_C; CpG binding protein zinc finger C terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9MS35 M9MS35
Q9W352.1 Q9W352

Gene LinkOut

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