Conserved Protein Domain Family
PHD_Cfp1
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cd15553: PHD_Cfp1 
PHD finger found in CXXC-type zinc finger protein 1 (Cfp1)
Cfp1, also termed CpG-binding protein, or PHD finger and CXXC domain-containing protein 1 (PCCX1), is a specificity factor that binds to unmethylated CpGs and links H3K4me3 with CpG islands (CGIs). It integrates both promoter CpG content and gene activity for accurate trimethylation of histone H3 Lys 4 (H3K4me3) deposition in embryonic stem cells. Moreover, Cfp1 is an essential component of the SETD1 histone H3K4 methyltransferase complex and functions as a critical regulator of histone methylation, cytosine methylation, cellular differentiation, and vertebrate development. Cfp1 contains a plant homeodomain (PHD) finger, a CXXC domain, and a CpG binding protein zinc finger C-terminal domain. Its CXXC domain selectively binds to non-methylated CpG islands, following by a preference for a guanosine nucleotide.
Links
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Statistics
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PSSM-Id: 277028
Aligned: 11 rows
Threshold Bit Score: 86.2766
Created: 12-Aug-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Zn binding siteputative
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C [CH] H [CH] C [CH]Click to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         # #           #  #    #  #                #  #
Q9P0U4        28 YCICRKPDincFMIGCDNCNEWFHGDCIRITEKMaka-irEWYCREC 73  human
AAI65319      27 YCICRKSDincFMIGCDNCNEWFHGHCINVTEKMaka-irEWYCQQC 72  zebrafish
EMP26554     252 YCICRKPDincFMIGCDNCNEWFHGNCINITEKMaka-irEWYCLQC 297 green seaturtle
NP_001085408  25 YCICRKPDincFMIGCDHCNEWFHGHCINITEKMaka-irEWYCMQC 70  African clawed frog
XP_004207256  40 FCICRSSDidrFMIACDKCMEWFHGDCVNIENKRaarkieEWYCQQC 86  green hydra
EKC23875      29 YCICRSKDstrFMIGCDNCEEWYHGDCIGVTQKDaeq-ikHFYCASC 74  Pacific oyster
XP_002738573  48 YCLCKSSEvdrFMIYCNNCHEWYHGDCVQITEHAskg-ikKWYCPPC 93  Saccoglossus kowalevskii
ELU13588       5 YCICRSTDcstFMIACDNCEEWYHGSCINVNANEaky-ikRFYCKIC 50  Capitella sp. I Grassle & Grassle, 1976
EFX66713      35 YCICRSSDasrFMIGCDYCEDWYHGDCIDITEEEsrf-ikKFFCPKC 80  common water flea
CBY10786      14 YCICRRVAnelFMIACDKCEEWFHGECIDLDESDaky-ikEFFCQAC 59  Oikopleura dioica
NP_572556     62 YCICRSSDcsrFMIGCDGCEEWYHGDCIGITEKEakh-ikQYYCRRC 107 fruit fly

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