U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cep152 centrosomal protein 152 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311391, updated on 17-Aug-2024

Summary

Go to the top of the page Help
Symbol
Cep152provided by RGD
Full Name
centrosomal protein 152provided by RGD
Primary source
RGD:1305348
See related
EnsemblRapid:ENSRNOG00000065817 AllianceGenome:RGD:1305348
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305348
Summary
Predicted to enable protein kinase binding activity. Predicted to be involved in centriole replication and de novo centriole assembly involved in multi-ciliated epithelial cell differentiation. Predicted to be located in deuterosome; microtubule organizing center; and nuclear body. Human ortholog(s) of this gene implicated in Seckel syndrome 5 and primary autosomal recessive microcephaly 9. Orthologous to human CEP152 (centrosomal protein 152). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 36.2), Spleen (RPKM 27.9) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Cep152 in Genome Data Viewer
Location:
3q36
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (133243979..133332271, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (112803185..112878298, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (117822799..117894856, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein eL8-like Neighboring gene uncharacterized LOC120101649 Neighboring gene fibrillin 1 Neighboring gene uncharacterized LOC120101652 Neighboring gene 40S ribosomal protein S14-like Neighboring gene SHC adaptor protein 4 Neighboring gene EP300 interacting inhibitor of differentiation 1 Neighboring gene SECIS binding protein 2-like Neighboring gene TATA element modulatory factor 1, pseudogene 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. CEP152 is a genome maintenance protein disrupted in Seckel syndrome. Kalay E, et al. Nat Genet, 2011 Jan. PMID 21131973, Free PMC Article
  2. Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosome. Cizmecioglu O, et al. J Cell Biol, 2010 Nov 15. PMID 21059844, Free PMC Article
  3. The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation. Tang CJ, et al. EMBO J, 2011 Oct 21. PMID 22020124, Free PMC Article
  4. The Cep63 paralogue Deup1 enables massive de novo centriole biogenesis for vertebrate multiciliogenesis. Zhao H, et al. Nat Cell Biol, 2013 Dec. PMID 24240477
  5. MDM1 is a microtubule-binding protein that negatively regulates centriole duplication. Van de Mark D, et al. Mol Biol Cell, 2015 Nov 1. PMID 26337392, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in centriole replication ISO
Inferred from Sequence Orthology
more info
  
involved_in centrosome duplication ISO
Inferred from Sequence Orthology
more info
  
involved_in de novo centriole assembly involved in multi-ciliated epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in deuterosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in pericentriolar material ISO
Inferred from Sequence Orthology
more info
  
located_in procentriole ISO
Inferred from Sequence Orthology
more info
  
part_of procentriole replication complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
centrosomal protein of 152 kDa
Names
centrosomal protein 152kDa

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427266.1 → NP_001414195.1  centrosomal protein of 152 kDa

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I5ZRX6
    Related
    ENSRNOP00000079893.2, ENSRNOT00000105077.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    133243979..133332271 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039106547.2 → XP_038962475.1  centrosomal protein of 152 kDa isoform X2

    Conserved Domains (3) summary
    PTZ00121
    Location:638 → 1090
    PTZ00121; MAEBL; Provisional
    PRK12704
    Location:1200 → 1387
    PRK12704; phosphodiesterase; Provisional
    TIGR02168
    Location:235 → 985
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  2. XM_039106550.2 → XP_038962478.1  centrosomal protein of 152 kDa isoform X6

    Conserved Domains (2) summary
    COG1196
    Location:625 → 1351
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:236 → 939
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  3. XM_039106551.2 → XP_038962479.1  centrosomal protein of 152 kDa isoform X7

    Conserved Domains (3) summary
    PTZ00121
    Location:571 → 1023
    PTZ00121; MAEBL; Provisional
    PRK12704
    Location:1133 → 1320
    PRK12704; phosphodiesterase; Provisional
    TIGR02168
    Location:168 → 918
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  4. XM_039106548.2 → XP_038962476.1  centrosomal protein of 152 kDa isoform X3

    Related
    ENSRNOP00000109904.1, ENSRNOT00000124472.1
    Conserved Domains (3) summary
    PTZ00121
    Location:639 → 1091
    PTZ00121; MAEBL; Provisional
    PRK12704
    Location:1201 → 1388
    PRK12704; phosphodiesterase; Provisional
    TIGR02168
    Location:236 → 986
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  5. XM_039106546.2 → XP_038962474.1  centrosomal protein of 152 kDa isoform X1

    Conserved Domains (3) summary
    PTZ00121
    Location:639 → 1091
    PTZ00121; MAEBL; Provisional
    PRK12704
    Location:1201 → 1388
    PRK12704; phosphodiesterase; Provisional
    TIGR02168
    Location:236 → 986
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  6. XM_063283746.1 → XP_063139816.1  centrosomal protein of 152 kDa isoform X5

  7. XM_008762222.4 → XP_008760444.2  centrosomal protein of 152 kDa isoform X4

    Conserved Domains (3) summary
    PTZ00121
    Location:617 → 1069
    PTZ00121; MAEBL; Provisional
    PRK12704
    Location:1179 → 1376
    PRK12704; phosphodiesterase; Provisional
    TIGR02168
    Location:235 → 964
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  8. XM_039106552.2 → XP_038962480.1  centrosomal protein of 152 kDa isoform X8

    Conserved Domains (3) summary
    PTZ00121
    Location:436 → 888
    PTZ00121; MAEBL; Provisional
    PRK12704
    Location:998 → 1195
    PRK12704; phosphodiesterase; Provisional
    TIGR02168
    Location:33 → 783
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  9. XM_063283748.1 → XP_063139818.1  centrosomal protein of 152 kDa isoform X10

  10. XM_039106553.2 → XP_038962481.1  centrosomal protein of 152 kDa isoform X9

    Conserved Domains (3) summary
    PTZ00121
    Location:411 → 863
    PTZ00121; MAEBL; Provisional
    PRK12704
    Location:973 → 1170
    PRK12704; phosphodiesterase; Provisional
    TIGR02168
    Location:8 → 758
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  11. XM_039106557.2 → XP_038962485.1  centrosomal protein of 152 kDa isoform X11

    Conserved Domains (2) summary
    PTZ00121
    Location:639 → 1091
    PTZ00121; MAEBL; Provisional
    COG1196
    Location:198 → 829
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RNA

  1. XR_010064629.1 RNA Sequence

  2. XR_010064628.1 RNA Sequence

  3. XR_010064627.1 RNA Sequence

  4. XR_010064630.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.