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Bnip2 BCL2 interacting protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 300811, updated on 17-Aug-2024

Summary

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Official Symbol
Bnip2provided by RGD
Official Full Name
BCL2 interacting protein 2provided by RGD
Primary source
RGD:1308944
See related
EnsemblRapid:ENSRNOG00000056024 AllianceGenome:RGD:1308944
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Involved in response to oxygen-glucose deprivation. Predicted to be located in cytoplasm; microtubule organizing center; and nuclear envelope. Orthologous to human BNIP2 (BCL2 interacting protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 206.7), Heart (RPKM 171.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
8q24
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (79521375..79539148)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (70640436..70661782)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (76400333..76426307)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene small ribosomal subunit protein eS10-like Neighboring gene uncharacterized LOC120094198 Neighboring gene general transcription factor 2A subunit 2 Neighboring gene glucosaminyl (N-acetyl) transferase 3, mucin type

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Differential expression of BNIP family members of BH3-only proteins during the development and after axotomy in the rat. Cho B, et al. Mol Cells, 2012 Jun. PMID 22639046, Free PMC Article
  2. Nip2/centrobin may be a substrate of Nek2 that is required for proper spindle assembly during mitosis in early mouse embryos. Sonn S, et al. Mol Reprod Dev, 2009 Jun. PMID 19117032
  3. Cdo promotes neuronal differentiation via activation of the p38 mitogen-activated protein kinase pathway. Oh JE, et al. FASEB J, 2009 Jul. PMID 19244314, Free PMC Article
  4. N-cadherin ligation, but not Sonic hedgehog binding, initiates Cdo-dependent p38alpha/beta MAPK signaling in skeletal myoblasts. Lu M, et al. Proc Natl Acad Sci U S A, 2010 Mar 2. PMID 20160094, Free PMC Article
  5. Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins. Boyd JM, et al. Cell, 1994 Oct 21. PMID 7954800

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within blastocyst development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within centrosome cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of small GTPase mediated signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in response to oxygen-glucose deprivation IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within striated muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in spindle pole centrosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2
Names
BCL2/adenovirus E1B 19kDa-interacting protein 1, NIP2
BCL2/adenovirus E1B interacting protein 2
Bcl-2 and E1B 19 kDa interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106835.1 → NP_001100305.1  BCL2/adenovirus E1B 19 kDa protein-interacting protein 2

    See identical proteins and their annotated locations for NP_001100305.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474041
    UniProtKB/TrEMBL
    A0A8I6AVU1, A6KEV4
    Conserved Domains (2) summary
    cd00170
    Location:147 → 290
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
    pfam12496
    Location:49 → 163
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    79521375..79539148
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006243370.5 → XP_006243432.1  BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006243432.1

    UniProtKB/TrEMBL
    A0A0G2K1P3, A6KEV3, D3ZGE0
    Related
    ENSRNOP00000070548.2, ENSRNOT00000081072.3
    Conserved Domains (2) summary
    cd00170
    Location:147 → 290
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
    pfam12496
    Location:49 → 163
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2

  2. XM_006243371.5 → XP_006243433.1  BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform X2

    See identical proteins and their annotated locations for XP_006243433.1

    UniProtKB/TrEMBL
    A0A8I6AVU1, A6KEV2
    Related
    ENSRNOP00000096973.2, ENSRNOT00000102436.2
    Conserved Domains (2) summary
    cd00170
    Location:147 → 290
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
    pfam12496
    Location:49 → 163
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
Nucleotide Protein Strain
Heading Accession and Version

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