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Lgals7 galectin 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29518, updated on 17-Aug-2024

Summary

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Official Symbol
Lgals7provided by RGD
Official Full Name
galectin 7provided by RGD
Primary source
RGD:61951
See related
EnsemblRapid:ENSRNOG00000020380 AllianceGenome:RGD:61951
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable carbohydrate binding activity and galactoside binding activity. Predicted to be involved in negative regulation of CD4-positive, alpha-beta T cell proliferation; negative regulation of interferon-gamma production; and positive regulation of gene expression. Predicted to be located in extracellular space. Predicted to be active in cytosol and nucleus. Orthologous to human LGALS7 (galectin 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 37.9), Muscle (RPKM 4.8) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lgals7 in Genome Data Viewer
Location:
1q21
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (93275092..93279529)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (84148612..84152016)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (87044823..87047223)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene MARCKS-related protein-like Neighboring gene uncharacterized LOC102550499 Neighboring gene galectin 4 Neighboring gene enoyl-CoA hydratase 1 Neighboring gene calpain 12 Neighboring gene actinin alpha 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Ultrasound‑targeted microbubble destruction‑mediated Galectin‑7‑siRNA promotes the homing of bone marrow mesenchymal stem cells to alleviate acute myocardial infarction in rats. Wei X, et al. Int J Mol Med, 2021 Feb. PMID 33416139, Free PMC Article
  2. Changes in galectin-7 and cytokeratin-19 expression during the progression of malignancy in thyroid tumors: diagnostic and biological implications. Rorive S, et al. Mod Pathol, 2002 Dec. PMID 12481010
  3. Galectin-7, a marker of all types of stratified epithelia. Magnaldo T, et al. Differentiation, 1998 Jul. PMID 9697310
  4. Galectin-7 modulates the length of the primary cilia and wound repair in polarized kidney epithelial cells. Rondanino C, et al. Am J Physiol Renal Physiol, 2011 Sep. PMID 21677144, Free PMC Article
  5. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ultrasoundtargeted microbubble destructionmediated Galectin7siRNA promotes the homing of bone marrow mesenchymal stem cells to alleviate acute myocardial infarction in rats.
    Title: Ultrasound‑targeted microbubble destruction‑mediated Galectin‑7‑siRNA promotes the homing of bone marrow mesenchymal stem cells to alleviate acute myocardial infarction in rats.
  2. Galectin-7 modulates the length of the primary cilia and wound repair in polarized kidney epithelial cells.
    Title: Galectin-7 modulates the length of the primary cilia and wound repair in polarized kidney epithelial cells.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables carbohydrate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cornified envelope ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
galectin-7
Names
gal-7
lectin, galactose binding, soluble 7
lectin, galactoside-binding, soluble, 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022582.2 → NP_072104.2  galectin-7

    See identical proteins and their annotated locations for NP_072104.2

    Status: VALIDATED

    Source sequence(s)
    BI278774, U67883
    UniProtKB/Swiss-Prot
    O54958, P97590
    UniProtKB/TrEMBL
    A6J9L7, F8WG95
    Related
    ENSRNOP00000027620.5, ENSRNOT00000027620.7
    Conserved Domains (1) summary
    pfam00337
    Location:5 → 135
    Gal-bind_lectin; Galactoside-binding lectin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    93275092..93279529
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109505.2 → XP_038965433.1  galectin-7 isoform X1

    UniProtKB/Swiss-Prot
    O54958, P97590
    UniProtKB/TrEMBL
    A6J9L7, F8WG95
    Conserved Domains (1) summary
    pfam00337
    Location:5 → 135
    Gal-bind_lectin; Galactoside-binding lectin

  2. XM_039109509.2 → XP_038965437.1  galectin-7 isoform X1

    UniProtKB/Swiss-Prot
    O54958, P97590
    UniProtKB/TrEMBL
    A6J9L7, F8WG95
    Conserved Domains (1) summary
    pfam00337
    Location:5 → 135
    Gal-bind_lectin; Galactoside-binding lectin
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97590.4 GenPept UniProtKB/Swiss-Prot:P97590

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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