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Conserved domains on  [gi|1958644850|ref|XP_038965433|]
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galectin-7 isoform X1 [Rattus norvegicus]

Protein Classification

galectin family protein( domain architecture ID 10049222)

galectin family protein may exclusively bind beta-galactosides such as lactose in a manner independent of metal ions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 5-134 1.01e-49

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


:

Pssm-ID: 238025  Cd Length: 127  Bit Score: 154.71  E-value: 1.01e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644850   5 HHKTPLPQGVRLGTVMRIRGVVPDQAGRFHVNLLCGEEqeaDAALHFNPRLDTSEVVFNTKQQGKWGREERGTGIPFQRG 84
Cdd:cd00070     1 PYKLPLPGGLKPGSTLTVKGRVLPNAKRFSINLGTGSS---DIALHFNPRFDENVIVRNSFLNGNWGPEERSGGFPFQPG 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958644850  85 QPFEVLIITTEEGFKTVIGDDEYLHFHHRMPSSNVRSVEVGGDVQLHSVK 134
Cdd:cd00070    78 QPFELTILVEEDKFQIFVNGQHFFSFPHRLPLESIDYLSINGDVSLTSVE 127
 
Name Accession Description Interval E-value
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 5-134 1.01e-49

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


Pssm-ID: 238025  Cd Length: 127  Bit Score: 154.71  E-value: 1.01e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644850   5 HHKTPLPQGVRLGTVMRIRGVVPDQAGRFHVNLLCGEEqeaDAALHFNPRLDTSEVVFNTKQQGKWGREERGTGIPFQRG 84
Cdd:cd00070     1 PYKLPLPGGLKPGSTLTVKGRVLPNAKRFSINLGTGSS---DIALHFNPRFDENVIVRNSFLNGNWGPEERSGGFPFQPG 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958644850  85 QPFEVLIITTEEGFKTVIGDDEYLHFHHRMPSSNVRSVEVGGDVQLHSVK 134
Cdd:cd00070    78 QPFELTILVEEDKFQIFVNGQHFFSFPHRLPLESIDYLSINGDVSLTSVE 127
Gal-bind_lectin pfam00337
Galactoside-binding lectin; This family contains galactoside binding lectins. The family also ...
 11-133 2.40e-49

Galactoside-binding lectin; This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).


Pssm-ID: 459768  Cd Length: 124  Bit Score: 153.95  E-value: 2.40e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644850  11 PQGVRLGTVMRIRGVVPDQAGRFHVNLLCGEEQEADAALHFNPRLDTSEVVFNTKQQGKWGREERGTGIPFQRGQPFEVL 90
Cdd:pfam00337   1 PGGLQPGSSLTIKGIVLPDAQRFSINLQTGVGPSDDIALHFNPRFDENVIVRNSRQNGQWGQEEREGGFPFQPGQPFELT 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1958644850  91 IITTEEGFKTVIGDDEYLHFHHRMPSSNVRSVEVGGDVQLHSV 133
Cdd:pfam00337  81 ILVGDDHFKIYVNGQHFTTFKHRLPPEDIDALQVRGDVKLTSV 123
Gal-bind_lectin smart00908
Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are ...
 11-134 1.33e-48

Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.


Pssm-ID: 214904  Cd Length: 122  Bit Score: 151.97  E-value: 1.33e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644850   11 PQGVRLGTVMRIRGVVPDQAGRFHVNLLCGEEqeADAALHFNPRLDTSEVVFNTKQQGKWGREERGTGIPFQRGQPFEVL 90
Cdd:smart00908   1 PGGLSPGSSITIRGIVLPDAKRFSINLQCGPN--ADIALHFNPRFDEGTIVRNSKQNGKWGKEERSGGFPFQPGQPFELE 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1958644850   91 IITTEEGFKTVIGDDEYLHFHHRMPSSNVRSVEVGGDVQLHSVK 134
Cdd:smart00908  79 ILVEEDEFKVAVNGQHFLEFPHRLPLESIDTLEISGDVQLTSVQ 122
 
Name Accession Description Interval E-value
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 5-134 1.01e-49

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


Pssm-ID: 238025  Cd Length: 127  Bit Score: 154.71  E-value: 1.01e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644850   5 HHKTPLPQGVRLGTVMRIRGVVPDQAGRFHVNLLCGEEqeaDAALHFNPRLDTSEVVFNTKQQGKWGREERGTGIPFQRG 84
Cdd:cd00070     1 PYKLPLPGGLKPGSTLTVKGRVLPNAKRFSINLGTGSS---DIALHFNPRFDENVIVRNSFLNGNWGPEERSGGFPFQPG 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958644850  85 QPFEVLIITTEEGFKTVIGDDEYLHFHHRMPSSNVRSVEVGGDVQLHSVK 134
Cdd:cd00070    78 QPFELTILVEEDKFQIFVNGQHFFSFPHRLPLESIDYLSINGDVSLTSVE 127
Gal-bind_lectin pfam00337
Galactoside-binding lectin; This family contains galactoside binding lectins. The family also ...
 11-133 2.40e-49

Galactoside-binding lectin; This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).


Pssm-ID: 459768  Cd Length: 124  Bit Score: 153.95  E-value: 2.40e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644850  11 PQGVRLGTVMRIRGVVPDQAGRFHVNLLCGEEQEADAALHFNPRLDTSEVVFNTKQQGKWGREERGTGIPFQRGQPFEVL 90
Cdd:pfam00337   1 PGGLQPGSSLTIKGIVLPDAQRFSINLQTGVGPSDDIALHFNPRFDENVIVRNSRQNGQWGQEEREGGFPFQPGQPFELT 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1958644850  91 IITTEEGFKTVIGDDEYLHFHHRMPSSNVRSVEVGGDVQLHSV 133
Cdd:pfam00337  81 ILVGDDHFKIYVNGQHFTTFKHRLPPEDIDALQVRGDVKLTSV 123
Gal-bind_lectin smart00908
Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are ...
 11-134 1.33e-48

Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.


Pssm-ID: 214904  Cd Length: 122  Bit Score: 151.97  E-value: 1.33e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644850   11 PQGVRLGTVMRIRGVVPDQAGRFHVNLLCGEEqeADAALHFNPRLDTSEVVFNTKQQGKWGREERGTGIPFQRGQPFEVL 90
Cdd:smart00908   1 PGGLSPGSSITIRGIVLPDAKRFSINLQCGPN--ADIALHFNPRFDEGTIVRNSKQNGKWGKEERSGGFPFQPGQPFELE 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1958644850   91 IITTEEGFKTVIGDDEYLHFHHRMPSSNVRSVEVGGDVQLHSVK 134
Cdd:smart00908  79 ILVEEDEFKVAVNGQHFLEFPHRLPLESIDTLEISGDVQLTSVQ 122
GLECT smart00276
Galectin; Galectin - galactose-binding lectin
 7-135 5.49e-44

Galectin; Galectin - galactose-binding lectin


Pssm-ID: 214596  Cd Length: 128  Bit Score: 140.44  E-value: 5.49e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958644850    7 KTPLPQGVRLGTVMRIRGVVPDQAGRFHVNLLCGEeqeADAALHFNPRLDTSEVVFNTKQQGKWGREERGTGIPFQRGQP 86
Cdd:smart00276   2 TLPIPGGLKPGQTLTVRGIVLPDAKRFSINLLTGG---DDIALHFNPRFNENKIVCNSKLNGSWGSEEREGGFPFQPGQP 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1958644850   87 FEVLIITTEEGFKTVIGDDEYLHFHHRMPSSNVRSVEVGGDVQLHSVKI 135
Cdd:smart00276  79 FDLTIIVQPDHFQIFVNGVHITTFPHRLPLESIDYLSINGDVQLTSVSF 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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