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MRPL42 mitochondrial ribosomal protein L42 [ Homo sapiens (human) ]

Gene ID: 28977, updated on 5-Mar-2024

Summary

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Official Symbol
MRPL42provided by HGNC
Official Full Name
mitochondrial ribosomal protein L42provided by HGNC
Primary source
HGNC:HGNC:14493
See related
Ensembl:ENSG00000198015 MIM:611847; AllianceGenome:HGNC:14493
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
mL42; L31MT; L42MT; S32MT; MRPL31; MRPS32; PTD007; RPML31; HSPC204; MRP-L31; MRP-L42; MRP-S32
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a protein identified as belonging to both the 28S and the 39S subunits. Alternative splicing results in multiple transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 4q, 6p, 6q, 7p, and 15q. [provided by RefSeq, May 2011]
Expression
Ubiquitous expression in adrenal (RPKM 12.4), thyroid (RPKM 10.6) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
12q22
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (93467514..93516214)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (93448482..93497696)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (93861290..93909990)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC643339 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4704 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:93764071-93765034 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:93771297-93772236 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6768 Neighboring gene nudix hydrolase 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4707 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4708 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:93835621-93836258 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4709 Neighboring gene ubiquitin conjugating enzyme E2 N Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6769 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6770 Neighboring gene uncharacterized LOC124902985 Neighboring gene RNA, 7SL, cytoplasmic 737, pseudogene Neighboring gene MPRA-validated peak1894 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4711 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4712 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4713 Neighboring gene SOCS2 antisense RNA 1 Neighboring gene suppressor of cytokine signaling 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Knockdown of MRPL42 suppresses glioma cell proliferation by inducing cell cycle arrest and apoptosis. Hao C, et al. Biosci Rep, 2018 Apr 27. PMID 29531015, Free PMC Article
  2. [Comparative analysis of the role of CD4(+) and CD8(+) T cells in severe asthma development]. Wang X, et al. Mol Biol (Mosk), 2015 May-Jun. PMID 26107902
  3. The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. Koc EC, et al. J Biol Chem, 2001 Nov 23. PMID 11551941
  4. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. Kenmochi N, et al. Genomics, 2001 Sep. PMID 11543634
  5. The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present. Cavdar Koc E, et al. J Biol Chem, 2001 Jun 1. PMID 11279123

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MRPL42 is a novel oncogene in glioma and might help us develop promising targetted therapies for glioma patients.
    Title: Knockdown of MRPL42 suppresses glioma cell proliferation by inducing cell cycle arrest and apoptosis.
  2. MPO and BPI in CD4(+)T-lymphocytes, and PDHA1 and MRPL42 in CD8(+) T-lymphocytes might be used as specific biomarkers of severe asthma progression.
    Title: [Comparative analysis of the role of CD4(+) and CD8(+) T cells in severe asthma development].
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Many sequence variants affecting diversity of adult human height.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev is identified to have a physical interaction with mitochondrial ribosomal protein L42 (MRPL42) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables structural constituent of ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
  
part_of mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mitochondrial large ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
part_of mitochondrial small ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
large ribosomal subunit protein mL42
Names
28S ribosomal protein S32, mitochondrial
39S ribosomal protein L31, mitochondrial
39S ribosomal protein L42, mitochondrial
mitochondrial large ribosomal subunit protein mL42

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014050.4 → NP_054769.1  large ribosomal subunit protein mL42 precursor

    See identical proteins and their annotated locations for NP_054769.1

    Status: REVIEWED

    Source sequence(s)
    AC025260
    Consensus CDS
    CCDS9045.1
    UniProtKB/Swiss-Prot
    Q6FID1, Q96Q48, Q9P0S1, Q9Y6G3
    UniProtKB/TrEMBL
    J3KPP0
    Related
    ENSP00000449884.1, ENST00000549982.6
    Conserved Domains (1) summary
    pfam10210
    Location:47 → 142
    MRP-S32; Mitochondrial 28S ribosomal protein S32

  2. NM_172177.5 → NP_751917.1  large ribosomal subunit protein mL42 precursor

    See identical proteins and their annotated locations for NP_751917.1

    Status: REVIEWED

    Source sequence(s)
    AC025260
    Consensus CDS
    CCDS9045.1
    UniProtKB/Swiss-Prot
    Q6FID1, Q96Q48, Q9P0S1, Q9Y6G3
    UniProtKB/TrEMBL
    J3KPP0
    Related
    ENSP00000447547.1, ENST00000552217.6
    Conserved Domains (1) summary
    pfam10210
    Location:47 → 142
    MRP-S32; Mitochondrial 28S ribosomal protein S32

RNA

  1. NR_038159.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC025260

  2. NR_038160.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC025260

  3. NR_038161.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC025260

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    93467514..93516214
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    93448482..93497696
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_172178.2: Suppressed sequence

    Description
    NM_172178.2: This RefSeq was permanently suppressed because the transcript is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y6G3.1 GenPept UniProtKB/Swiss-Prot:Q9Y6G3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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