U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pcnp PEST proteolytic signal containing nuclear protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 288165, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Pcnpprovided by RGD
Official Full Name
PEST proteolytic signal containing nuclear proteinprovided by RGD
Primary source
RGD:1563775
See related
EnsemblRapid:ENSRNOG00000028411 AllianceGenome:RGD:1563775
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ab2-416
Summary
Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to be located in nuclear body. Predicted to be active in nucleus. Orthologous to human PCNP (PEST proteolytic signal containing nuclear protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 272.6), Lung (RPKM 254.5) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Pcnp in Genome Data Viewer
Location:
11q12
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (58061885..58076436)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (44592766..44607372)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (47055641..47070319)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene SUMO specific peptidase 7 Neighboring gene uncharacterized LOC120095650 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene tRNA methyltransferase 10C, mitochondrial RNase P subunit Neighboring gene zinc finger and BTB domain containing 11 Neighboring gene small nucleolar RNA SNORA29 Neighboring gene G protein subunit gamma 5, pseudogene 4

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. NIRF, a novel RING finger protein, is involved in cell-cycle regulation. Mori T, et al. Biochem Biophys Res Commun, 2002 Aug 23. PMID 12176013
  2. NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP, a PEST-containing nuclear protein. Mori T, et al. FEBS Lett, 2004 Jan 16. PMID 14741369
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
PEST proteolytic signal-containing nuclear protein
Names
PEST-containing nuclear protein
liver regeneration-related protein LRRG084

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395615.1 → NP_001382544.1  PEST proteolytic signal-containing nuclear protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    A0A0H2UHW4, A6IQQ1
    Conserved Domains (1) summary
    pfam15473
    Location:23 → 171
    PCNP; PEST, proteolytic signal-containing nuclear protein family

  2. NM_001395616.1 → NP_001382545.1  PEST proteolytic signal-containing nuclear protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    A0A0H2UHW4, A0A8I5ZNV8
    Conserved Domains (1) summary
    pfam15473
    Location:23 → 170
    PCNP; PEST, proteolytic signal-containing nuclear protein family

  3. NM_001395617.1 → NP_001382546.1  PEST proteolytic signal-containing nuclear protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    A6IQQ2
    Conserved Domains (1) summary
    pfam15473
    Location:1 → 104
    PCNP; PEST, proteolytic signal-containing nuclear protein family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    58061885..58076436
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270407.1 → XP_063126477.1  PEST proteolytic signal-containing nuclear protein isoform X1

    Related
    ENSRNOP00000039022.5, ENSRNOT00000039997.6

  2. XM_063270408.1 → XP_063126478.1  PEST proteolytic signal-containing nuclear protein isoform X2

    UniProtKB/Swiss-Prot
    Q7TP40

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001047846.1: Suppressed sequence

    Description
    NM_001047846.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TP40.1 GenPept UniProtKB/Swiss-Prot:Q7TP40

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools