Conserved Protein Domain Family
PCNP
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pfam15473: PCNP (this model, PSSM-Id:406035 is obsolete and has been replaced by 464736)
PEST, proteolytic signal-containing nuclear protein family
PCNP is a PEST-containing nuclear protein that is ubiquitinated by NIRF, a Np95/ICBP90-like RING finger protein. PEST sequences, which are rich in proline (P), glutamic acid (E), serine (S) and threonine (T), are found in a number of short-lived proteins, such as transcription factors and cell cycle-associated proteins. Their function is generally controlled by proteolysis, mostly via ubiquitin-mediated degradation. Thus, NIRF and PCNP are a ubiquitin ligase and its substrate, respectively, that may constitute a novel signalling pathway with some relation to cell proliferation.
Links
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Statistics
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PSSM-Id: 406035
Aligned: 11 rows
Threshold Bit Score: 158.859
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q17H13        47 EDRRRKEQLQKHNPLRPLPGGRKDSGSSSDDSGDDDNGSQSKT---APPKPSVMPKIGFSFQKPAANAKtsstlstsfnl 123 yellow fever mo...
XP_001847943  45 EERQRKEAQLRKAAESQRKYDHRRSSSSSGSSSSDGSDNEGPV---APPAPPVISKVGFSFQKPPSAKPtstgf-----q 116 southern house ...
OWR45283      37 RRRRVSPSGHRGSPSRPG-RSRERNLENADKRRYSESWEESDEevpAPPPPPRISKISIDFSKPK--------------- 100 Danaus plexippu...
XP_001122504   8 deyRKGSSVYRAEDSRGDDRGRDRSPLRSDDRCEEANYNQSDA---------KKQKLAFGFGKKSGTEQk---------- 68  honey bee
XP_004911769  37 EEEAEKAVNTKNVSS----SNGGESSSRSAEKRAAEDSK-------NAPHPFKVSKIGFAIGNQNLKKS----------- 94  tropical clawed...
XP_001363703  24 EEEAEKPVKTKTVSS----SNGGENSSRSAEKRSAEEEAEDFS---SKPVPAKIAKFGFAIGSQTAKKA----------- 85  gray short-tail...
XP_006743063  28 ARE--------TAASWSRRSNGGESSSRSAEKRSAEEEAAD-----LPTKPTKISKFGFAIGSQTTKKA----------- 83  Weddell seal
NP_001313647  18 EEKGSS-VKTKTVSS-------SKASGDSLRKRPAREIDPEDEs-kSTSAPPKMFKSGFSM---TAKKP----------- 74  zebrafish
XP_004067142  18 QEEGDR-VKTKPVSC-STVGGDGAAYKRTSQHLSAEEEDESSE---DPPAPRKVSKLGFSMSSQAATKS----------- 81  Japanese medaka
CAF99796      18 QEEEGR-VKTKPISC-STVGGKGTAFKRTSQHLAPEDDDEDEAs-qIPPAHCKISKIGLKMSSQMGKKS----------- 83  spotted green p...
XP_006639248  18 EEKGGKGVKTKTVSS----SNGGGSNTRSADKRSAEEAAGDSM---VQPAPPKVSKIGLS--SQALKKP----------- 77  spotted gar

Q17H13       124 qkaKPMAIQMKLG--TAPKKETPKL--LKPVANAfAGSDSDEEPEEMPAECRMRMRNIGRDTPTSSGPNSFGKTKHGFCD 199 yellow fever mo...
XP_001847943 117 lqqKPSAVQLKLA--SGPKKEQPKL--LKPTANA-FADDSDDEPEEMPAECRMRMRNIGRETPTSSGPNSFGKTKHGFCD 191 southern house ...
OWR45283     101 ---APIKMTLGAT--SKPA--------PKPTVASvFNADDDDEPEEMPAEARMRMRNIGRETPTSAGPNSFGKTKQGFCD 167 Danaus plexippu...
XP_001122504  69 ---KGIQIKLGST--SKPTVKATPI--QRPTVASvFNADEEDEPEEMPAEARMRMRNIGRETPTSAGPNSFGKTKQGFCD 141 honey bee
XP_004911769  95 ---QPISIKLGAS---KPKEVAPAVvkKKTAVASvFNDDDDSEPEEMPPEAKMRMKNIGRDTPTSAGPNSFNKGKHGFSD 168 tropical clawed...
XP_001363703  86 ---PVISIKLGAS---KPKETVPTLapKTLSVAAvFNEDDDSEPEEMPPEAKMRMKNIGRDTPTSAGPNSFNKGKHGFSD 159 gray short-tail...
XP_006743063  84 ---SAISIKLGSS---KPKETVATLapKTLSVAAaFNEDEDSEPEEMPPEAKMRMKNIGRDTPTSAGPNSFNKGKHGFSD 157 Weddell seal
NP_001313647  75 ---MAISIKLGAN---KPKEPPPAIppKKSGLASvFNEDDDSEPEEMPPEAKMRMKNIGRETPTSAGPNSFNKGKQGFSD 148 zebrafish
XP_004067142  82 ---NAISIKLGAT---KPKEPVPSLppKKPALASvFNDSDDSEPEEMPPEAKMRMKNIGRETPTSAGPNSFNKGKQGFSD 155 Japanese medaka
CAF99796      84 ---NPISIKLGATvsVKPKEPVPSVppKKPGLASvFNEDDDSEPEEMPPEAKMRMKNIGRETPTSAGPNSFNKGKHGFSD 160 spotted green p...
XP_006639248  78 ---APISIKLGAS---KPKESAPVLpaKKPALAAvFNEDEDSEPEEMPPEAKMRMKNIGRDTPTSAGPNSFNKGKHGFSD 151 spotted gar

Q17H13       200 SKKIFEKKLNTM 211 yellow fever mosquito
XP_001847943 192 SKKMLEKKLNSL 203 southern house mosquito
OWR45283     168 AKKVFEKNLKQA 179 Danaus plexippus plexippus
XP_001122504 142 SKKIFEKTLKKA 153 honey bee
XP_004911769 169 SQKLWERNMKAQ 180 tropical clawed frog
XP_001363703 160 NQKLWERNIKSH 171 gray short-tailed opossum
XP_006743063 158 NQKLWERNIKSH 169 Weddell seal
NP_001313647 149 HQKLWERKLKSH 160 zebrafish
XP_004067142 156 HQKLWERKIKAQ 167 Japanese medaka
CAF99796     161 NQRLWERKIKTQ 172 spotted green pufferfish
XP_006639248 152 HQKLWERKLKTH 163 spotted gar
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