U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ACACA acetyl-CoA carboxylase alpha [ Bos taurus (domestic cattle) ]

Gene ID: 281590, updated on 10-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
ACACAprovided by VGNC
Official Full Name
acetyl-CoA carboxylase alphaprovided by VGNC
Primary source
VGNC:VGNC:25519
See related
BGD:BT12301; Ensembl:ENSBTAG00000017567
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
ACC1; ACCA
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ACACA in Genome Data Viewer
Location:
chromosome: 19
Exon count:
62
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (13439554..13726306, complement)

Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene LIM homeobox 1 Neighboring gene apoptosis antagonizing transcription factor Neighboring gene U6atac minor spliceosomal RNA Neighboring gene uncharacterized LOC112442606 Neighboring gene chromosome 19 C17orf78 homolog Neighboring gene uncharacterized LOC132343012 Neighboring gene transcriptional adaptor 2A Neighboring gene dual specificity phosphatase 14

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Characterization of a far upstream located promoter expressing the acetyl-CoA carboxylase-alpha in the brain of cattle. Shi X, et al. Gene, 2013 Feb 25. PMID 23262334
  2. The SNPs in the ACACA gene are effective on fatty acid composition in Holstein milk. Matsumoto H, et al. Mol Biol Rep, 2012 Sep. PMID 22718502
  3. Genomic distribution of three promoters of the bovine gene encoding acetyl-CoA carboxylase alpha and evidence that the nutritionally regulated promoter I contains a repressive element different from that in rat. Mao J, et al. Biochem J, 2001 Aug 15. PMID 11485560, Free PMC Article
  4. Associations of polymorphisms in the promoter I of bovine acetyl-CoA carboxylase-alpha gene with beef fatty acid composition. Zhang S, et al. Anim Genet, 2010 Aug. PMID 20002363
  5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression profiles showed that PI is the promoter driving expression of the dominant ACACA-transcript in brain.
    Title: Characterization of a far upstream located promoter expressing the acetyl-CoA carboxylase-alpha in the brain of cattle.
  2. Since the promoter region, PIII, is specific to mammary gland during lactation, the altered expression of the ACACA gene owing to the SNPs in the PIII region may influence the fatty acid composition in the milk.
    Title: The SNPs in the ACACA gene are effective on fatty acid composition in Holstein milk.
  3. results suggested that the SNPs in the promoter I region of ACACA gene are associated with variations in the fatty acid contents in longissimus dorsi muscle.
    Title: Associations of polymorphisms in the promoter I of bovine acetyl-CoA carboxylase-alpha gene with beef fatty acid composition.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables acetyl-CoA carboxylase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
acetyl-CoA carboxylase 1
Names
ACC-alpha
acetyl-coenzyme A carboxylase alpha
NP_776649.1
XP_005220032.1
XP_005220033.1
XP_005220034.1
XP_005220035.1
XP_010814045.1
XP_024835369.1
XP_024835371.1
XP_024835374.1
XP_024835375.1
XP_059733697.1
XP_059733698.1
XP_059733699.1
XP_059733700.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174224.2 → NP_776649.1  acetyl-CoA carboxylase 1

    See identical proteins and their annotated locations for NP_776649.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ132890
    UniProtKB/Swiss-Prot
    Q9TTS3
    UniProtKB/TrEMBL
    A0A3Q1MAY0
    Related
    ENSBTAP00000023364.5, ENSBTAT00000023364.7
    Conserved Domains (5) summary
    COG0439
    Location:118 → 620
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:671 → 818
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00364
    Location:754 → 818
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1669 → 2217
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:820 → 1569
    ACC_central; Acetyl-CoA carboxylase, central region

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    13439554..13726306 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024979601.2 → XP_024835369.1  acetyl-CoA carboxylase 1 isoform X3

    UniProtKB/TrEMBL
    A0A3Q1LIN4
    Conserved Domains (5) summary
    COG0439
    Location:155 → 657
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00364
    Location:790 → 855
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1698 → 2246
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:857 → 1591
    ACC_central; Acetyl-CoA carboxylase, central region
    cl27427
    Location:708 → 855
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

  2. XM_005219975.5 → XP_005220032.1  acetyl-CoA carboxylase 1 isoform X1

    See identical proteins and their annotated locations for XP_005220032.1

    UniProtKB/TrEMBL
    A0A3Q1LIN4, A0A3Q1MUW1
    Related
    ENSBTAP00000074493.1, ENSBTAT00000087370.2
    Conserved Domains (8) summary
    COG0439
    Location:155 → 657
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:708 → 855
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00289
    Location:155 → 274
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam00364
    Location:790 → 855
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1706 → 2254
    Carboxyl_trans; Carboxyl transferase domain
    pfam02785
    Location:544 → 651
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    pfam08326
    Location:857 → 1606
    ACC_central; Acetyl-CoA carboxylase, central region
    cl17255
    Location:316 → 507
    ATP-grasp_4; ATP-grasp domain

  3. XM_059877716.1 → XP_059733699.1  acetyl-CoA carboxylase 1 isoform X4

    UniProtKB/TrEMBL
    E1BGH6

  4. XM_059877715.1 → XP_059733698.1  acetyl-CoA carboxylase 1 isoform X4

    UniProtKB/TrEMBL
    E1BGH6

  5. XM_010815743.4 → XP_010814045.1  acetyl-CoA carboxylase 1 isoform X4

    See identical proteins and their annotated locations for XP_010814045.1

    UniProtKB/TrEMBL
    A0A3Q1MAY0, E1BGH6
    Related
    ENSBTAP00000067794.2, ENSBTAT00000080617.2
    Conserved Domains (5) summary
    COG0439
    Location:118 → 620
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00364
    Location:753 → 818
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1669 → 2217
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:820 → 1562
    ACC_central; Acetyl-CoA carboxylase, central region
    cl27427
    Location:671 → 818
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

  6. XM_005219976.5 → XP_005220033.1  acetyl-CoA carboxylase 1 isoform X4

    See identical proteins and their annotated locations for XP_005220033.1

    UniProtKB/TrEMBL
    A0A3Q1MAY0, E1BGH6
    Conserved Domains (5) summary
    COG0439
    Location:118 → 620
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00364
    Location:753 → 818
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1669 → 2217
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:820 → 1562
    ACC_central; Acetyl-CoA carboxylase, central region
    cl27427
    Location:671 → 818
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

  7. XM_024979603.2 → XP_024835371.1  acetyl-CoA carboxylase 1 isoform X5

    UniProtKB/TrEMBL
    F1MSC3
    Related
    ENSBTAP00000029559.6, ENSBTAT00000029560.6
    Conserved Domains (5) summary
    COG0439
    Location:118 → 620
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00364
    Location:753 → 818
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1661 → 2209
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:820 → 1554
    ACC_central; Acetyl-CoA carboxylase, central region
    cl27427
    Location:671 → 818
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

  8. XM_005219978.5 → XP_005220035.1  acetyl-CoA carboxylase 1 isoform X4

    See identical proteins and their annotated locations for XP_005220035.1

    UniProtKB/TrEMBL
    A0A3Q1MAY0, E1BGH6
    Conserved Domains (5) summary
    COG0439
    Location:118 → 620
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00364
    Location:753 → 818
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1669 → 2217
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:820 → 1562
    ACC_central; Acetyl-CoA carboxylase, central region
    cl27427
    Location:671 → 818
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

  9. XM_059877714.1 → XP_059733697.1  acetyl-CoA carboxylase 1 isoform X2

    Related
    ENSBTAP00000058963.2, ENSBTAT00000085804.2

  10. XM_059877717.1 → XP_059733700.1  acetyl-CoA carboxylase 1 isoform X7

  11. XM_024979606.2 → XP_024835374.1  acetyl-CoA carboxylase 1 isoform X8

    UniProtKB/TrEMBL
    F1MSC3
    Conserved Domains (5) summary
    COG0439
    Location:60 → 562
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00364
    Location:695 → 760
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1603 → 2151
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:762 → 1496
    ACC_central; Acetyl-CoA carboxylase, central region
    cl27427
    Location:613 → 760
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

  12. XM_005219977.5 → XP_005220034.1  acetyl-CoA carboxylase 1 isoform X6

    See identical proteins and their annotated locations for XP_005220034.1

    UniProtKB/TrEMBL
    A0A3Q1M483, A0A3Q1MAY0
    Related
    ENSBTAP00000065001.1, ENSBTAT00000075315.2
    Conserved Domains (8) summary
    COG0439
    Location:60 → 562
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:613 → 760
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00289
    Location:60 → 179
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam00364
    Location:695 → 760
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1611 → 2159
    Carboxyl_trans; Carboxyl transferase domain
    pfam02785
    Location:449 → 556
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    pfam08326
    Location:762 → 1511
    ACC_central; Acetyl-CoA carboxylase, central region
    cl17255
    Location:221 → 412
    ATP-grasp_4; ATP-grasp domain

  13. XM_024979607.2 → XP_024835375.1  acetyl-CoA carboxylase 1 isoform X9

    UniProtKB/TrEMBL
    F1MSC3
    Conserved Domains (5) summary
    COG0439
    Location:18 → 473
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00364
    Location:606 → 671
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1522 → 2070
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:673 → 1415
    ACC_central; Acetyl-CoA carboxylase, central region
    cl27427
    Location:524 → 671
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9TTS3.1 GenPept UniProtKB/Swiss-Prot:Q9TTS3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.