U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

P4HB prolyl 4-hydroxylase subunit beta [ Bos taurus (domestic cattle) ]

Gene ID: 281373, updated on 4-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
P4HBprovided by VGNC
Official Full Name
prolyl 4-hydroxylase subunit betaprovided by VGNC
Primary source
VGNC:VGNC:32538
See related
BGD:BT18140; Ensembl:ENSBTAG00000006045
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
PDI
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See P4HB in Genome Data Viewer
Location:
chromosome: 19
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (51034603..51044546)

Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene Rho GDP dissociation inhibitor alpha Neighboring gene proteasome assembly chaperone 3-like Neighboring gene protein phosphatase 1 regulatory subunit 27 Neighboring gene MAPK regulated corepressor interacting protein 1

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Sequence of membrane-associated thyroid hormone binding protein from bovine liver: its identity with protein disulphide isomerase. Yamauchi K, et al. Biochem Biophys Res Commun, 1987 Aug 14. PMID 3619939
  2. [Interaction of rotavirus with protein disulfide isomerase in vitro and cell system]. Calderón MN, et al. Biomedica, 2011 Mar. PMID 22159485
  3. Protein disulfide isomerase is a component of the microsomal triglyceride transfer protein complex. Wetterau JR, et al. J Biol Chem, 1990 Jun 15. PMID 2351674
  4. Thioredoxin-1 and protein disulfide isomerase catalyze the reduction of similar disulfides in HIV gp120. Reiser K, et al. Int J Biochem Cell Biol, 2012 Mar. PMID 22230366
  5. Analysis of bovine mammary gland EST and functional annotation of the Bos taurus gene index. Sonstegard TS, et al. Mamm Genome, 2002 Jul. PMID 12140684

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein disulfide isomerase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to endoplasmic reticulum stress IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
protein disulfide-isomerase
Names
PDI (E.C.5.3.4.1)
cellular thyroid hormone binding protein
p55
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide
prolyl 4-hydroxylase beta polypeptide
prolyl 4-hydroxylase, beta subunit
NP_776560.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174135.3 → NP_776560.1  protein disulfide-isomerase precursor

    See identical proteins and their annotated locations for NP_776560.1

    Status: PROVISIONAL

    Source sequence(s)
    M17596
    UniProtKB/Swiss-Prot
    P05307
    UniProtKB/TrEMBL
    A6H7J6
    Related
    ENSBTAP00000007943.5, ENSBTAT00000007943.6
    Conserved Domains (5) summary
    cd02981
    Location:139 → 234
    PDI_b_family; Protein Disulfide Isomerase (PDIb) family, redox inactive TRX-like domain b; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family ...
    cd02982
    Location:246 → 349
    PDI_b'_family; Protein Disulfide Isomerase (PDIb') family, redox inactive TRX-like domain b'; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family ...
    cd02995
    Location:370 → 472
    PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
    TIGR01130
    Location:26 → 476
    ER_PDI_fam; protein disulfide isomerase, eukaryotic
    cl00388
    Location:31 → 135
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    51034603..51044546
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P05307.1 GenPept UniProtKB/Swiss-Prot:P05307

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.