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SIGLEC7 sialic acid binding Ig like lectin 7 [ Homo sapiens (human) ]

Gene ID: 27036, updated on 3-Apr-2024

Summary

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Official Symbol
SIGLEC7provided by HGNC
Official Full Name
sialic acid binding Ig like lectin 7provided by HGNC
Primary source
HGNC:HGNC:10876
See related
Ensembl:ENSG00000168995 MIM:604410; AllianceGenome:HGNC:10876
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p75; QA79; AIRM1; CD328; AIRM-1; CDw328; D-siglec; SIGLEC-7; SIGLECP2; SIGLEC19P; p75/AIRM1
Summary
Predicted to enable sialic acid binding activity. Predicted to be involved in cell adhesion. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen (RPKM 7.6), appendix (RPKM 5.3) and 14 other tissues See more
Orthologs
all
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Genomic context

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Location:
19q13.41
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (51142301..51153526)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (54230909..54242134)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51645558..51656783)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene sialic acid binding Ig like lectin 18, pseudogene Neighboring gene sialic acid binding Ig like lectin 9 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15009 Neighboring gene uncharacterized LOC124904749 Neighboring gene uncharacterized LOC101928517 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:51660802-51661000 Neighboring gene Sharpr-MPRA regulatory region 7523 Neighboring gene sialic acid binding Ig like lectin 17, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:51684473-51685444 Neighboring gene sialic acid binding Ig like lectin 20, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Histone deacetylation-regulated cell surface Siglec-7 expression promoted megakaryocytic maturation and enhanced platelet-like particle release. Huang YF, et al. J Thromb Haemost, 2023 Feb. PMID 36700509
  2. Siglec-7 represents a glyco-immune checkpoint for non-exhausted effector memory CD8+ T cells with high functional and metabolic capacities. Haas Q, et al. Front Immunol, 2022. PMID 36211376, Free PMC Article
  3. Regulation of Siglec-7-mediated varicella-zoster virus infection of primary monocytes by cis-ligands. Suenaga T, et al. Biochem Biophys Res Commun, 2022 Jul 12. PMID 35526487
  4. Siglec-7 mediates varicella-zoster virus infection by associating with glycoprotein B. Suenaga T, et al. Biochem Biophys Res Commun, 2022 Jun 4. PMID 35367830
  5. Siglec-7 is an indicator of natural killer cell function in acute myeloid leukemia. Yang L, et al. Int Immunopharmacol, 2021 Oct. PMID 34273636

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The glycoimmune checkpoint receptor Siglec-7 interacts with T-cell ligands and regulates T-cell activation.
    Title: The glycoimmune checkpoint receptor Siglec-7 interacts with T-cell ligands and regulates T-cell activation.
  2. Histone deacetylation-regulated cell surface Siglec-7 expression promoted megakaryocytic maturation and enhanced platelet-like particle release.
    Title: Histone deacetylation-regulated cell surface Siglec-7 expression promoted megakaryocytic maturation and enhanced platelet-like particle release.
  3. Siglec-7 represents a glyco-immune checkpoint for non-exhausted effector memory CD8+ T cells with high functional and metabolic capacities.
    Title: Siglec-7 represents a glyco-immune checkpoint for non-exhausted effector memory CD8+ T cells with high functional and metabolic capacities.
  4. Regulation of Siglec-7-mediated varicella-zoster virus infection of primary monocytes by cis-ligands.
    Title: Regulation of Siglec-7-mediated varicella-zoster virus infection of primary monocytes by cis-ligands.
  5. Siglec-7 mediates varicella-zoster virus infection by associating with glycoprotein B.
    Title: Siglec-7 mediates varicella-zoster virus infection by associating with glycoprotein B.
  6. Siglec-7 is an indicator of natural killer cell function in acute myeloid leukemia.
    Title: Siglec-7 is an indicator of natural killer cell function in acute myeloid leukemia.
  7. Identification and functional characterization of a Siglec-7 counter-receptor on K562 cells.
    Title: Identification and functional characterization of a Siglec-7 counter-receptor on K562 cells.
  8. Decidual glycodelin-A polarizes human monocytes into a decidual macrophage-like phenotype through Siglec-7.
    Title: Decidual glycodelin-A polarizes human monocytes into a decidual macrophage-like phenotype through Siglec-7.
  9. Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7.
    Title: Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7.
  10. The conserved arginine residue in all siglecs is essential for Siglec-7 binding to sialic acid.
    Title: The conserved arginine residue in all siglecs is essential for Siglec-7 binding to sialic acid.
Submit: New GeneRIF Correction See all GeneRIFs (38)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env SIGLEC7 binds to HIV-1 gp120 and enhances HIV-1 infection of CD4+ T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sialic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
sialic acid-binding Ig-like lectin 7
Names
QA79 membrane protein
adhesion inhibitory receptor molecule 1, siglec-7
sialic acid binding immunoglobulin-like lectin 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277201.2 → NP_001264130.1  sialic acid-binding Ig-like lectin 7 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001264130.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks all internal coding exons, compared to variant 1. The resulting isoform (3) is C-terminal truncated, compared to isoform 1.
    Source sequence(s)
    AJ007395, AJ130713, BX644517
    Consensus CDS
    CCDS62771.1
    UniProtKB/Swiss-Prot
    Q9Y286
    Related
    ENSP00000472529.1, ENST00000600577.1
    Conserved Domains (2) summary
    cd05712
    Location:26 → 144
    Ig_Siglec_N; Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
    smart00410
    Location:31 → 122
    IG_like; Immunoglobulin like

  2. NM_014385.4 → NP_055200.1  sialic acid-binding Ig-like lectin 7 isoform 1 precursor

    See identical proteins and their annotated locations for NP_055200.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC063977
    Consensus CDS
    CCDS12826.1
    UniProtKB/Swiss-Prot
    Q9NZQ1, Q9UJ86, Q9UJ87, Q9Y286, Q9Y502
    Related
    ENSP00000323328.6, ENST00000317643.10
    Conserved Domains (3) summary
    cd05712
    Location:26 → 144
    Ig_Siglec_N; Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
    smart00410
    Location:261 → 336
    IG_like; Immunoglobulin like
    cl11960
    Location:150 → 223
    Ig; Immunoglobulin domain

  3. NM_016543.4 → NP_057627.2  sialic acid-binding Ig-like lectin 7 isoform 2 precursor

    See identical proteins and their annotated locations for NP_057627.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AJ007395, AJ130711, BX644517
    Consensus CDS
    CCDS42601.1
    UniProtKB/Swiss-Prot
    Q9Y286
    Related
    ENSP00000306757.6, ENST00000305628.7
    Conserved Domains (3) summary
    cd05712
    Location:26 → 144
    Ig_Siglec_N; Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
    smart00410
    Location:168 → 243
    IG_like; Immunoglobulin like
    pfam13895
    Location:167 → 245
    Ig_2; Immunoglobulin domain

RNA

  1. NR_102350.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks multiple internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AJ007395, AJ130712

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    51142301..51153526
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526721.4 → XP_011525023.1  sialic acid-binding Ig-like lectin 7 isoform X1

    Conserved Domains (3) summary
    cd05712
    Location:26 → 144
    Ig_Siglec_N; Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
    smart00410
    Location:152 → 227
    IG_like; Immunoglobulin like
    pfam13895
    Location:151 → 229
    Ig_2; Immunoglobulin domain

  2. XM_047438604.1 → XP_047294560.1  sialic acid-binding Ig-like lectin 7 isoform X2

  3. XM_047438605.1 → XP_047294561.1  sialic acid-binding Ig-like lectin 7 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    54230909..54242134
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320538.1 → XP_054176513.1  sialic acid-binding Ig-like lectin 7 isoform X1

  2. XM_054320539.1 → XP_054176514.1  sialic acid-binding Ig-like lectin 7 isoform X2

  3. XM_054320540.1 → XP_054176515.1  sialic acid-binding Ig-like lectin 7 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y286.1 GenPept UniProtKB/Swiss-Prot:Q9Y286

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