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Conserved domains on  [gi|469469047|ref|NP_001264130|]
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sialic acid-binding Ig-like lectin 7 isoform 3 precursor [Homo sapiens]

Protein Classification

Ig_Siglec_N domain-containing protein( domain architecture ID 10145899)

Ig_Siglec_N domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_CD33 cd05712
Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic ...
 26-144 1.68e-67

Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins); The members here are composed of the immunoglobulin (Ig) domain at the N-terminus of Cluster of Differentiation (CD) 33 and related Siglecs (sialic acid-binding Ig-like lectins). Siglec refers to a structurally related protein family that specifically recognizes sialic acid in oligosaccharide chains of glycoproteins and glycolipids. Siglecs are type I transmembrane proteins, organized as an extracellular module composed of Ig-like domains, an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains, followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG, the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11.


:

Pssm-ID: 409377  Cd Length: 119  Bit Score: 199.92  E-value: 1.68e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469469047  26 YSLTMQSSVTVQEGMCVHVRCSFSYPVDSQtDSDPVHGYWFRAGNDISWKAPVATNNPAWAVQEETRDRFHLLGDPQTKN 105
Cdd:cd05712    1 WGLQMPKSVTVQEGLCVLIPCSFSYPADYW-VSNPVHGYWYRGGPYPKYRPPVATNNRTREVHESTQGRFRLLGDPGKKN 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 469469047 106 CTLSIRDARMSDAGRYFFRMEKG-NIKWNYKYDQLSVNVT 144
Cdd:cd05712   80 CSLSISDARPEDSGKYFFRVERGdSNKYSYLSNQLSLTVT 119
 
Name Accession Description Interval E-value
IgV_CD33 cd05712
Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic ...
 26-144 1.68e-67

Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins); The members here are composed of the immunoglobulin (Ig) domain at the N-terminus of Cluster of Differentiation (CD) 33 and related Siglecs (sialic acid-binding Ig-like lectins). Siglec refers to a structurally related protein family that specifically recognizes sialic acid in oligosaccharide chains of glycoproteins and glycolipids. Siglecs are type I transmembrane proteins, organized as an extracellular module composed of Ig-like domains, an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains, followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG, the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11.


Pssm-ID: 409377  Cd Length: 119  Bit Score: 199.92  E-value: 1.68e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469469047  26 YSLTMQSSVTVQEGMCVHVRCSFSYPVDSQtDSDPVHGYWFRAGNDISWKAPVATNNPAWAVQEETRDRFHLLGDPQTKN 105
Cdd:cd05712    1 WGLQMPKSVTVQEGLCVLIPCSFSYPADYW-VSNPVHGYWYRGGPYPKYRPPVATNNRTREVHESTQGRFRLLGDPGKKN 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 469469047 106 CTLSIRDARMSDAGRYFFRMEKG-NIKWNYKYDQLSVNVT 144
Cdd:cd05712   80 CSLSISDARPEDSGKYFFRVERGdSNKYSYLSNQLSLTVT 119
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 29-125 1.55e-10

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 54.77  E-value: 1.55e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469469047   29 TMQSSVTVQEGMCVHVRCSFSYPVDSQTDSdpVhgYWFR--AGNDISWKAPVATNNpawAVQEETRDRFHLLGDPQTKNC 106
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSMSEASTS--V--YWYRqpPGKGPTFLIAYYSNG---SEEGVKKGRFSGRGDPSNGDG 73

                          90
                  ....*....|....*....
gi 469469047  107 TLSIRDARMSDAGRYFFRM 125
Cdd:pfam07686  74 SLTIQNLTLSDSGTYTCAV 92
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 31-122 1.44e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 38.26  E-value: 1.44e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469469047    31 QSSVTVQEGMCVHVRCSFSypvdsqtDSDPVHGYWFRagNDISWKAPvatnnpawavqeetRDRFHLlgDPQTKNCTLSI 110
Cdd:smart00410   1 PPSVTVKEGESVTLSCEAS-------GSPPPEVTWYK--QGGKLLAE--------------SGRFSV--SRSGSTSTLTI 55

                           90
                   ....*....|..
gi 469469047   111 RDARMSDAGRYF 122
Cdd:smart00410  56 SNVTPEDSGTYT 67
 
Name Accession Description Interval E-value
IgV_CD33 cd05712
Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic ...
 26-144 1.68e-67

Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins); The members here are composed of the immunoglobulin (Ig) domain at the N-terminus of Cluster of Differentiation (CD) 33 and related Siglecs (sialic acid-binding Ig-like lectins). Siglec refers to a structurally related protein family that specifically recognizes sialic acid in oligosaccharide chains of glycoproteins and glycolipids. Siglecs are type I transmembrane proteins, organized as an extracellular module composed of Ig-like domains, an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains, followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG, the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11.


Pssm-ID: 409377  Cd Length: 119  Bit Score: 199.92  E-value: 1.68e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469469047  26 YSLTMQSSVTVQEGMCVHVRCSFSYPVDSQtDSDPVHGYWFRAGNDISWKAPVATNNPAWAVQEETRDRFHLLGDPQTKN 105
Cdd:cd05712    1 WGLQMPKSVTVQEGLCVLIPCSFSYPADYW-VSNPVHGYWYRGGPYPKYRPPVATNNRTREVHESTQGRFRLLGDPGKKN 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 469469047 106 CTLSIRDARMSDAGRYFFRMEKG-NIKWNYKYDQLSVNVT 144
Cdd:cd05712   80 CSLSISDARPEDSGKYFFRVERGdSNKYSYLSNQLSLTVT 119
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 29-125 1.55e-10

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 54.77  E-value: 1.55e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469469047   29 TMQSSVTVQEGMCVHVRCSFSYPVDSQTDSdpVhgYWFR--AGNDISWKAPVATNNpawAVQEETRDRFHLLGDPQTKNC 106
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSMSEASTS--V--YWYRqpPGKGPTFLIAYYSNG---SEEGVKKGRFSGRGDPSNGDG 73

                          90
                  ....*....|....*....
gi 469469047  107 TLSIRDARMSDAGRYFFRM 125
Cdd:pfam07686  74 SLTIQNLTLSDSGTYTCAV 92
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 31-122 7.58e-07

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 44.95  E-value: 7.58e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469469047  31 QSSVTVQEGMCVHVRCSFSypvdsqtDSDPVHGYWFRagnDISWKAPVATNNPAWAVQEETRDRFHLLGDPQTKNCTLSI 110
Cdd:cd04983    5 PQSLSVQEGENVTLNCNYS-------TSTFYYLFWYR---QYPGQGPQFLIYISSDSGNKKKGRFSATLDKSRKSSSLHI 74

                         90
                 ....*....|..
gi 469469047 111 RDARMSDAGRYF 122
Cdd:cd04983   75 SAAQLSDSAVYF 86
IgV_CD22_d1 cd20929
First immunoglobulin domain of Cluster of Differentiation (CD) 22; member of the V-set of IgSF ...
 38-132 1.85e-06

First immunoglobulin domain of Cluster of Differentiation (CD) 22; member of the V-set of IgSF domains; The members here are composed of the first immunoglobulin domain in Cluster of Differentiation (CD) 22 (also known as Siglec-2). CD22, a sialic-acid binding immunoglobulin type-lectin (Siglec) family member, is an inhibitory co-receptor of the B-cell receptor (BCR). The inhibitory function of CD22 and its restricted expression on B cells makes CD22 an attractive target against dysregulated B cells that cause autoimmune diseases and B-cell-derived cancers. CD22 plays a vital role in establishing a baseline level of B-cell inhibition, and thus is an important determinant of homeostasis in humoral immunity. Siglecs are primarily expressed on immune cells and recognize sialic acid-containing glycan ligands. Siglecs are organized as an extracellular module composed of Ig-like domains (an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains), followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG (Siglec-4, myelin-associated glycoprotein), the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the V-set of IgSF domains.


Pssm-ID: 409523  Cd Length: 114  Bit Score: 44.22  E-value: 1.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469469047  38 EGMCVHVRCSFSYPvDSQTDSDPV-HGYWFRAGNDiSWKAPVATNNPAWAVQEETRDRFHLLGDpQTKNCTLSIRDARMS 116
Cdd:cd20929   13 EGACVWIPCTYRAL-DGDLESFILfHNPEYNKATS-KFDGTRLYESTKDGKVPSEQKRVQFLGD-KNKNCTLSIHPVHLN 89

                         90
                 ....*....|....*.
gi 469469047 117 DAGRYFFRMEKGNIKW 132
Cdd:cd20929   90 DSGQLGLRMESKTEKW 105
IgV_1_PVR_like cd05718
First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 ...
 33-121 4.38e-05

First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 and necl-5), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and nectin-like protein 5 (necl-5)). Poliovirus (PV) binds to its cellular receptor (PVR/CD155) to initiate infection. CD155 is a membrane-anchored, single-span glycoprotein; its extracellular region has three Ig-like domains. There are four different isotypes of CD155 (referred to as alpha, beta, gamma, and delta), that result from alternate splicing of the CD155 mRNA, and have identical extracellular domains. CD155-beta and CD155-gamma are secreted; CD155-alpha and CD155-delta are membrane-bound and function as PV receptors. The virus recognition site is contained in the amino-terminal domain, D1. Having the virus attachment site on the receptor distal from the plasma membrane may be important for successful initiation of infection of cells by the virus. CD155 binds in the poliovirus "canyon" with a footprint similar to that of the intercellular adhesion molecule-1 receptor on human rhinoviruses. This group also includes the first Ig-like domain of nectin-1 (also known as poliovirus receptor related protein(PVRL)1; CD111), nectin-3 (also known as PVRL 3), nectin-4 (also known as PVRL4; LNIR receptor)and DNAX accessory molecule 1 (DNAM-1; CD226).


Pssm-ID: 409383  Cd Length: 113  Bit Score: 40.51  E-value: 4.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469469047  33 SVTVQEGMCVHVRCSFSYPVD---SQTDsdpvhgyWFRAGNDISwkAPVATNNPAW--AVQEETRDRFHLLGDPQT-KNC 106
Cdd:cd05718    8 EVTGFLGGSVTLPCSLTSPGTtkiTQVT-------WMKIGAGSS--QNVAVFHPQYgpSVPNPYAERVEFLAARLGlRNA 78

                         90
                 ....*....|....*
gi 469469047 107 TLSIRDARMSDAGRY 121
Cdd:cd05718   79 TLRIRNLRVEDEGNY 93
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 31-122 1.44e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 38.26  E-value: 1.44e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469469047    31 QSSVTVQEGMCVHVRCSFSypvdsqtDSDPVHGYWFRagNDISWKAPvatnnpawavqeetRDRFHLlgDPQTKNCTLSI 110
Cdd:smart00410   1 PPSVTVKEGESVTLSCEAS-------GSPPPEVTWYK--QGGKLLAE--------------SGRFSV--SRSGSTSTLTI 55

                           90
                   ....*....|..
gi 469469047   111 RDARMSDAGRYF 122
Cdd:smart00410  56 SNVTPEDSGTYT 67
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 31-122 2.57e-03

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 35.39  E-value: 2.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469469047  31 QSSVTVQEGMCVHVRCSFSypvdSQTDSDPVHgyWFR--AGNDISWKAPVATNNPAwaVQEETRDRFHLLGDPqTKNCTL 108
Cdd:cd00099    5 PRSLSVQEGESVTLSCEVS----SSFSSTYIY--WYRqkPGQGPEFLIYLSSSKGK--TKGGVPGRFSGSRDG-TSSFSL 75

                         90
                 ....*....|....
gi 469469047 109 SIRDARMSDAGRYF 122
Cdd:cd00099   76 TISNLQPEDSGTYY 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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