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Chd5 chromodomain helicase DNA binding protein 5 [ Mus musculus (house mouse) ]

Gene ID: 269610, updated on 18-Sep-2024

Summary

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Official Symbol
Chd5provided by MGI
Official Full Name
chromodomain helicase DNA binding protein 5provided by MGI
Primary source
MGI:MGI:3036258
See related
Ensembl:ENSMUSG00000005045 AllianceGenome:MGI:3036258
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CHD-5; 4930532L22Rik; B230399N07Rik
Summary
Enables H3K27me3 modified histone binding activity and histone deacetylase binding activity. Involved in several processes, including cerebral cortex neuron differentiation; positive regulation of signal transduction by p53 class mediator; and spermatogenesis, exchange of chromosomal proteins. Located in heterochromatin and nucleus. Part of NuRD complex. Is expressed in central nervous system and dorsal root ganglion. Orthologous to human CHD5 (chromodomain helicase DNA binding protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 38.0), frontal lobe adult (RPKM 16.9) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Chd5 in Genome Data Viewer
Location:
4 E2; 4 83.04 cM
Exon count:
43
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (152423103..152474651)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (152338646..152390194)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9430083M05 gene Neighboring gene STARR-positive B cell enhancer ABC_E846 Neighboring gene isoprenylcysteine carboxyl methyltransferase Neighboring gene ring finger protein 207 Neighboring gene ribosomal protein L22 Neighboring gene potassium voltage-gated channel, shaker-related subfamily, beta member 2 Neighboring gene predicted gene 16333 Neighboring gene nephronophthisis 4 (juvenile) homolog (human)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Chd5 Regulates MuERV-L/MERVL Expression in Mouse Embryonic Stem Cells Via H3K27me3 Modification and Histone H3.1/H3.2. Hayashi M, et al. J Cell Biochem, 2016 Mar. PMID 26359639
  2. Differential expression and sex chromosome association of CHD3/4 and CHD5 during spermatogenesis. Bergs JW, et al. PLoS One, 2014. PMID 24849318, Free PMC Article
  3. Chd5 orchestrates chromatin remodelling during sperm development. Li W, et al. Nat Commun, 2014 May 13. PMID 24818823, Free PMC Article
  4. Chd5 Regulates the Transcription Factor Six3 to Promote Neuronal Differentiation. Shrestha P, et al. Stem Cells, 2023 Mar 17. PMID 36636025, Free PMC Article
  5. Mice lacking the chromodomain helicase DNA-binding 5 chromatin remodeler display autism-like characteristics. Pisansky MT, et al. Transl Psychiatry, 2017 Jun 13. PMID 28608855, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Chd5 Regulates the Transcription Factor Six3 to Promote Neuronal Differentiation.
    Title: Chd5 Regulates the Transcription Factor Six3 to Promote Neuronal Differentiation.
  2. Pyramidal neurons cultured from Chd5(-/-) cortex displayed alterations in dendritic morphology. Paralleling autism spectrum disorder nosology, Chd5(-/-) mice exhibited abnormal sociocommunicative behavior and a strong preference for familiarity. Chd5(-/-) mice further showed deficits in responding to the distress of a conspecific, a mouse homolog of empathy.
    Title: Mice lacking the chromodomain helicase DNA-binding 5 chromatin remodeler display autism-like characteristics.
  3. Chd5 represses murine endogenous retrovirus-L (MuERV-L/MERVL), an endogenous retrovirus-derived retrotransposon, by regulating H3K27me3 and H3.1/H3.2 function.
    Title: Chd5 Regulates MuERV-L/MERVL Expression in Mouse Embryonic Stem Cells Via H3K27me3 Modification and Histone H3.1/H3.2.
  4. Chd5 is a multi-faceted mediator of histone-to-protamine replacement and is important in the cascade of molecular events underlying this process of extensive chromatin remodelling.
    Title: Chd5 orchestrates chromatin remodelling during sperm development.
  5. Our data indicate that CHD5 is required for normal spermiogenesis, especially for spermatid chromatin condensation.
    Title: CHD5 is required for spermiogenesis and chromatin condensation.
  6. Chd5 expression is retained at high levels in differentiated neurons of the adult mouse.
    Title: The tumor suppressor Chd5 is induced during neuronal differentiation in the developing mouse brain.
  7. These findings provide insights into the regulatory role of CHD5 during neurogenesis and suggest how inactivation of this candidate tumor suppressor might contribute to neuroblastoma.
    Title: CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and polycomb gene repression.
  8. Chd5 binds the unmodified N terminus of H3 through its tandem plant homeodomains (PHDs).
    Title: Chd5 requires PHD-mediated histone 3 binding for tumor suppression.
  9. CHD5 regulates expression of neuronal genes, cell cycle genes and remodeling genes, and is linked to regulation of genes implicated in aging and Alzheimer's disease.
    Title: CHD5, a brain-specific paralog of Mi2 chromatin remodeling enzymes, regulates expression of neuronal genes.
  10. the association of between miR-211-regulated CHD5 expression and CHD5 function in colorectal tumorigenesis
    Title: MicroRNA-211 expression promotes colorectal cancer cell growth in vitro and in vivo by targeting tumor suppressor CHD5.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (5)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent chromatin remodeler activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP-dependent chromatin remodeler activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables H3K27me3 modified histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables H3K27me3 modified histone binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone deacetylase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cerebral cortex neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of signal transduction by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sperm DNA condensation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of NuRD complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NuRD complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
chromodomain-helicase-DNA-binding protein 5
Names
ATP-dependent helicase CHD5
NP_001074845.1
NP_001356172.1
NP_083492.2
XP_006538992.1
XP_006538993.1
XP_006538994.1
XP_006538996.1
XP_006538998.1
XP_017175733.1
XP_030109449.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081376.1 → NP_001074845.1  chromodomain-helicase-DNA-binding protein 5 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL611985
    Consensus CDS
    CCDS38984.1
    UniProtKB/TrEMBL
    E9PYL1
    Related
    ENSMUSP00000030775.6, ENSMUST00000030775.12
    Conserved Domains (10) summary
    smart00298
    Location:594 → 648
    CHROMO; Chromatin organization modifier domain
    cd00046
    Location:722 → 880
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd15531
    Location:347 → 389
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:420 → 462
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    pfam00176
    Location:705 → 1001
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:1025 → 1140
    Helicase_C; Helicase conserved C-terminal domain
    pfam06461
    Location:1390 → 1531
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:1300 → 1360
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:153 → 202
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:1730 → 1901
    CHDCT2; CHDCT2 (NUC038) domain

  2. NM_001369243.1 → NP_001356172.1  chromodomain-helicase-DNA-binding protein 5 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL611985
    Consensus CDS
    CCDS89866.1
    UniProtKB/Swiss-Prot
    A2A8L1, Q6ZQB2
    Related
    ENSMUSP00000005175.5, ENSMUST00000005175.5
    Conserved Domains (10) summary
    PLN03142
    Location:700 → 1218
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    PRK13108
    Location:1532 → 1684
    PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
    cd15531
    Location:347 → 389
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:420 → 462
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    pfam06461
    Location:1390 → 1531
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam08074
    Location:1730 → 1901
    CHDCT2; CHDCT2 (NUC038) domain
    pfam06465
    Location:1300 → 1359
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:153 → 203
    CHDNT; CHDNT (NUC034) domain
    cd18662
    Location:591 → 644
    CD2_tandem_CHD3-4_like; repeat 2 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 3 and 4, and similar proteins
    cd18667
    Location:467 → 546
    CD1_tandem_CHD3-4_like; repeat 1 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 3 and 4, and similar proteins

  3. NM_029216.2 → NP_083492.2  chromodomain-helicase-DNA-binding protein 5 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon, compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
    Source sequence(s)
    AL611985
    Consensus CDS
    CCDS51394.1
    UniProtKB/TrEMBL
    E9PYU4
    Related
    ENSMUSP00000132600.2, ENSMUST00000164662.8
    Conserved Domains (10) summary
    smart00298
    Location:594 → 648
    CHROMO; Chromatin organization modifier domain
    cd00046
    Location:722 → 880
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd15531
    Location:347 → 389
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:420 → 462
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    pfam00176
    Location:705 → 1001
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:1025 → 1140
    Helicase_C; Helicase conserved C-terminal domain
    pfam06461
    Location:1353 → 1494
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:1263 → 1323
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:153 → 202
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:1693 → 1864
    CHDCT2; CHDCT2 (NUC038) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    152423103..152474651
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538929.2 → XP_006538992.1  chromodomain-helicase-DNA-binding protein 5 isoform X1

    Conserved Domains (10) summary
    PLN03142
    Location:700 → 1218
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    PRK13108
    Location:1535 → 1687
    PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
    cd15531
    Location:347 → 389
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:420 → 462
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd18662
    Location:591 → 644
    CD2_tandem_CHD3-4_like; repeat 2 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 3 and 4, and similar proteins
    cd18667
    Location:467 → 546
    CD1_tandem_CHD3-4_like; repeat 1 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 3 and 4, and similar proteins
    pfam06461
    Location:1393 → 1534
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:1300 → 1359
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:148 → 203
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:1733 → 1904
    CHDCT2; CHDCT2 (NUC038) domain

  2. XM_006538933.2 → XP_006538996.1  chromodomain-helicase-DNA-binding protein 5 isoform X5

    Conserved Domains (10) summary
    PLN03142
    Location:700 → 1240
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    PRK13108
    Location:1498 → 1650
    PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
    cd15531
    Location:347 → 389
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:420 → 462
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd18662
    Location:591 → 644
    CD2_tandem_CHD3-4_like; repeat 2 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 3 and 4, and similar proteins
    cd18667
    Location:467 → 546
    CD1_tandem_CHD3-4_like; repeat 1 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 3 and 4, and similar proteins
    pfam06461
    Location:1356 → 1497
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:1263 → 1322
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:148 → 203
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:1696 → 1867
    CHDCT2; CHDCT2 (NUC038) domain

  3. XM_006538930.2 → XP_006538993.1  chromodomain-helicase-DNA-binding protein 5 isoform X2

    Conserved Domains (10) summary
    PLN03142
    Location:700 → 1217
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    PRK13108
    Location:1534 → 1686
    PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
    cd15531
    Location:347 → 389
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:420 → 462
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd18662
    Location:591 → 644
    CD2_tandem_CHD3-4_like; repeat 2 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 3 and 4, and similar proteins
    cd18667
    Location:467 → 546
    CD1_tandem_CHD3-4_like; repeat 1 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 3 and 4, and similar proteins
    pfam06461
    Location:1392 → 1533
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:1299 → 1358
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:148 → 203
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:1732 → 1903
    CHDCT2; CHDCT2 (NUC038) domain

  4. XM_017320244.2 → XP_017175733.1  chromodomain-helicase-DNA-binding protein 5 isoform X3

    Conserved Domains (10) summary
    PLN03142
    Location:700 → 1217
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    PRK13108
    Location:1531 → 1683
    PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
    cd15531
    Location:347 → 389
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:420 → 462
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd18662
    Location:591 → 644
    CD2_tandem_CHD3-4_like; repeat 2 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 3 and 4, and similar proteins
    cd18667
    Location:467 → 546
    CD1_tandem_CHD3-4_like; repeat 1 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 3 and 4, and similar proteins
    pfam06461
    Location:1389 → 1530
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:1299 → 1358
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:148 → 203
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:1729 → 1900
    CHDCT2; CHDCT2 (NUC038) domain

  5. XM_006538931.2 → XP_006538994.1  chromodomain-helicase-DNA-binding protein 5 isoform X4

    Conserved Domains (10) summary
    PLN03142
    Location:700 → 1218
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    PRK13108
    Location:1535 → 1687
    PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
    cd15531
    Location:347 → 389
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:420 → 462
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd18662
    Location:591 → 644
    CD2_tandem_CHD3-4_like; repeat 2 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 3 and 4, and similar proteins
    cd18667
    Location:467 → 546
    CD1_tandem_CHD3-4_like; repeat 1 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 3 and 4, and similar proteins
    pfam06461
    Location:1393 → 1534
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:1300 → 1359
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:148 → 203
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:1733 → 1904
    CHDCT2; CHDCT2 (NUC038) domain

  6. XM_006538935.2 → XP_006538998.1  chromodomain-helicase-DNA-binding protein 5 isoform X7

    Conserved Domains (10) summary
    PLN03142
    Location:700 → 1218
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    PRK13108
    Location:1535 → 1687
    PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
    cd15531
    Location:347 → 389
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:420 → 462
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd18662
    Location:591 → 644
    CD2_tandem_CHD3-4_like; repeat 2 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 3 and 4, and similar proteins
    cd18667
    Location:467 → 546
    CD1_tandem_CHD3-4_like; repeat 1 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 3 and 4, and similar proteins
    pfam06461
    Location:1393 → 1534
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:1300 → 1359
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:148 → 203
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:1733 → 1860
    CHDCT2; CHDCT2 (NUC038) domain

  7. XM_030253589.1 → XP_030109449.1  chromodomain-helicase-DNA-binding protein 5 isoform X6

    Conserved Domains (10) summary
    PLN03142
    Location:626 → 1144
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    PRK13108
    Location:1461 → 1613
    PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
    cd15531
    Location:273 → 315
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:346 → 388
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd18662
    Location:517 → 570
    CD2_tandem_CHD3-4_like; repeat 2 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 3 and 4, and similar proteins
    cd18667
    Location:393 → 472
    CD1_tandem_CHD3-4_like; repeat 1 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 3 and 4, and similar proteins
    pfam06461
    Location:1319 → 1460
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:1226 → 1285
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:74 → 129
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:1659 → 1830
    CHDCT2; CHDCT2 (NUC038) domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2A8L1.1 GenPept UniProtKB/Swiss-Prot:A2A8L1

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