Or6k8-ps1 olfactory receptor family 6 subfamily K member 8, pseudogene 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Or6k8-ps1provided by MGI
Official Full Name: olfactory receptor family 6 subfamily K member 8, pseudogene 1provided by MGI
Primary source: MGI:MGI:3030255
See related: Ensembl:ENSMUSG00000091950 AllianceGenome:MGI:3030255
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Olfr421; MOR105-3; Olfr421-ps1; Olfr422-ps1
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This olfactory receptor gene appears to represent a strain-specific polymorphic pseudogene in mouse, where some strains, including the C57BL/6 reference genome strain, have a non-functional allele, while other strains have a protein-coding allele. [provided by RefSeq, Apr 2012]
Annotation information: Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
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Genomic context

Location:: 1 H3; 1 80.94 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (173979047..173980096)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (174151481..174152530)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables olfactory receptor activity	ISA Inferred from Sequence Alignment more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISA Inferred from Sequence Alignment more info	PubMed
acts_upstream_of_or_within sensory perception of smell	ISA Inferred from Sequence Alignment more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	ISA Inferred from Sequence Alignment more info	PubMed

General protein information

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Preferred Names: olfactory receptor family 6 subfamily K member 8

Names: GA_x6K02T2P20D-21002372-21001425; GA_x6K02T2P20D-21006310-21006124; olfactory receptor 421, pseudogene 1; olfactory receptor 422, pseudogene 1; olfactory receptor MOR105-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_146720.3 → NP_666931.3 olfactory receptor family 6 subfamily K member 8

See identical proteins and their annotated locations for NP_666931.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the functional non-reference strain allele and encodes the full-length protein.

Source sequence(s)

BC119233

UniProtKB/TrEMBL

Q8VFZ0

Conserved Domains (2) summary

pfam00001
Location:41 → 289

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:33 → 305

7tm_4; Olfactory receptor

RNA

NR_047667.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (1, non-coding) includes a premature stop codon and represents the non-functional allele, as in the C57BL/6 reference genome.

Source sequence(s)

AC113483

Related

ENSMUST00000179386.2