NCBI Conserved Domain Search

Conserved domains on [gi|384551642|ref|NP_666931|]

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olfactory receptor family 6 subfamily K member 8 [Mus musculus]

Protein Classification

G protein-coupled receptor family protein; olfactory receptor( domain architecture ID 11610379)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters; olfactory receptor plays a central role in olfaction or the sense of smell, similar to human family 6 olfactory receptors; belongs to the class A rhodopsin-like family of G protein-coupled receptors; binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf)

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

7tmA_OR6N-like

cd15914

olfactory receptor OR6N and related proteins, member of the class A family of ...

25-293

5.91e-152

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320580 [Multi-domain] Cd Length: 270 Bit Score: 426.79 E-value: 5.91e-152

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  25 LLYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFF 104
Cdd:cd15914    1 LLLFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 105 HSLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPL 184
Cdd:cd15914   81 HSLGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 185 LKLACTDASV-ILVQDVIHALAILITSLIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRFSA 263
Cdd:cd15914  161 LSLACTDTSLnVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSK 240

                        250       260       270
                 ....*....|....*....|....*....|
gi 384551642 264 TYTPFWDNTIALTFSVFAPLFNPIIYSLRN 293
Cdd:cd15914  241 SYSLDYDRAIAVVYAVLTPFFNPIIYSLRN 270

Name

Accession

Description

Interval

E-value

7tmA_OR6N-like

cd15914

olfactory receptor OR6N and related proteins, member of the class A family of ...

25-293

5.91e-152

Pssm-ID: 320580 [Multi-domain] Cd Length: 270 Bit Score: 426.79 E-value: 5.91e-152

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  25 LLYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFF 104
Cdd:cd15914    1 LLLFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 105 HSLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPL 184
Cdd:cd15914   81 HSLGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 185 LKLACTDASV-ILVQDVIHALAILITSLIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRFSA 263
Cdd:cd15914  161 LSLACTDTSLnVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSK 240

                        250       260       270
                 ....*....|....*....|....*....|
gi 384551642 264 TYTPFWDNTIALTFSVFAPLFNPIIYSLRN 293
Cdd:cd15914  241 SYSLDYDRAIAVVYAVLTPFFNPIIYSLRN 270

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

33-305

1.94e-52

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 173.46 E-value: 1.94e-52

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642   33 FIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFHSLGNTEG 112
Cdd:pfam13853   3 LMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMES 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  113 TLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPLLKLACTDA 192
Cdd:pfam13853  83 AVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADI 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  193 SVILVQDVIHALAIL-ITSLIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYL--RFSATYTPFW 269
Cdd:pfam13853 163 KVNNIYGLFVVTSTFgIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMvhRFGHNVPPLL 242

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 384551642  270 DNTIALTFSVFAPLFNPIIYSLRNKDMKDAINKLIC 305
Cdd:pfam13853 243 QIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRMLL 278

Name

Accession

Description

Interval

E-value

7tmA_OR6N-like

cd15914

olfactory receptor OR6N and related proteins, member of the class A family of ...

25-293

5.91e-152

Pssm-ID: 320580 [Multi-domain] Cd Length: 270 Bit Score: 426.79 E-value: 5.91e-152

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  25 LLYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFF 104
Cdd:cd15914    1 LLLFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 105 HSLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPL 184
Cdd:cd15914   81 HSLGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 185 LKLACTDASV-ILVQDVIHALAILITSLIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRFSA 263
Cdd:cd15914  161 LSLACTDTSLnVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSK 240

                        250       260       270
                 ....*....|....*....|....*....|
gi 384551642 264 TYTPFWDNTIALTFSVFAPLFNPIIYSLRN 293
Cdd:cd15914  241 SYSLDYDRAIAVVYAVLTPFFNPIIYSLRN 270

7tmA_OR

cd13954

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...

25-293

1.56e-122

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320092 [Multi-domain] Cd Length: 270 Bit Score: 352.17 E-value: 1.56e-122

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  25 LLYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFF 104
Cdd:cd13954    1 ILLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 105 HSLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPL 184
Cdd:cd13954   81 FSLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 185 LKLACTDASVILVQDVIHALAILITS-LIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRFSA 263
Cdd:cd13954  161 LKLSCSDTSLNELVIFILAGFVGLGSfLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSS 240

                        250       260       270
                 ....*....|....*....|....*....|
gi 384551642 264 TYTPFWDNTIALTFSVFAPLFNPIIYSLRN 293
Cdd:cd13954  241 SYSSDLDKVVSVFYTVVTPMLNPIIYSLRN 270

7tmA_OR10A-like

cd15225

olfactory receptor subfamily 10A and related proteins, member of the class A family of ...

25-300

2.16e-120

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320353 Cd Length: 277 Bit Score: 346.75 E-value: 2.16e-120

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  25 LLYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFF 104
Cdd:cd15225    1 LLLFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 105 HSLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPL 184
Cdd:cd15225   81 LFLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 185 LKLACTDASVI-LVQDVIHALAILITSLIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRFSA 263
Cdd:cd15225  161 LKLACADTSLNeIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKS 240

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 384551642 264 TYTPFWDNTIALTFSVFAPLFNPIIYSLRNKDMKDAI 300
Cdd:cd15225  241 SYSPETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR6C-like

cd15912

olfactory receptor subfamily 6C and related proteins, member of the class A family of ...

25-293

1.37e-110

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320578 Cd Length: 270 Bit Score: 321.74 E-value: 1.37e-110

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  25 LLYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFF 104
Cdd:cd15912    1 ILLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 105 HSLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPL 184
Cdd:cd15912   81 FFLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 185 LKLACTDASVILVQDVIHALAILITSLIISL-SYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRFSA 263
Cdd:cd15912  161 LKLSCSDTRLIELLDFILASVVLLGSLLLTIvSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQ 240

                        250       260       270
                 ....*....|....*....|....*....|
gi 384551642 264 TYTPFWDNTIALTFSVFAPLFNPIIYSLRN 293
Cdd:cd15912  241 SSSLDLNKVVALLNTVVTPLLNPFIYTLRN 270

7tmA_OR5V1-like

cd15231

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...

25-300

3.36e-102

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320359 [Multi-domain] Cd Length: 277 Bit Score: 300.72 E-value: 3.36e-102

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  25 LLYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFF 104
Cdd:cd15231    1 LLLFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 105 HSLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPL 184
Cdd:cd15231   81 VSFVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 185 LKLACTDASVILVqdVIHALAILI---TSLIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRF 261
Cdd:cd15231  161 LKLSCSDTSLNEV--LLLVASVFIgltPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRP 238

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 384551642 262 SATYTPFWDNTIALTFSVFAPLFNPIIYSLRNKDMKDAI 300
Cdd:cd15231  239 SSGYSLDKDTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR6B-like

cd15224

olfactory receptor subfamily 6B and related proteins, member of the class A family of ...

25-293

2.06e-101

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320352 Cd Length: 270 Bit Score: 298.43 E-value: 2.06e-101

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  25 LLYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFF 104
Cdd:cd15224    1 LLLFLLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 105 HSLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPL 184
Cdd:cd15224   81 LSLACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 185 LKLACTDASVILVQDVIHALAILITSL-IISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRFSA 263
Cdd:cd15224  161 LNLSCTDMSLAELVDFILALIILLVPLlVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPKA 240

                        250       260       270
                 ....*....|....*....|....*....|
gi 384551642 264 TYTPFWDNTIALTFSVFAPLFNPIIYSLRN 293
Cdd:cd15224  241 ISSFDSNKLVSVLYTVVTPLLNPIIYCLRN 270

7tmA_OR1A-like

cd15235

olfactory receptor subfamily 1A and related proteins, member of the class A family of ...

26-300

3.16e-101

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320363 [Multi-domain] Cd Length: 278 Bit Score: 298.37 E-value: 3.16e-101

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  26 LYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFH 105
Cdd:cd15235    3 LLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 106 SLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPLL 185
Cdd:cd15235   83 AFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQPLL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 186 KLACTDASVILVQDVIHALAILITSLI-ISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRFSAT 264
Cdd:cd15235  163 KLSCSDTSLNELLIFTEGAVVVLGPFLlIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPSSS 242

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 384551642 265 YTPFWDNTIALTFSVFAPLFNPIIYSLRNKDMKDAI 300
Cdd:cd15235  243 YSADKDRVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278

7tmA_OR11A-like

cd15911

olfactory receptor subfamily 11A and related proteins, member of the class A family of ...

25-293

6.24e-101

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320577 Cd Length: 270 Bit Score: 297.09 E-value: 6.24e-101

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  25 LLYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFF 104
Cdd:cd15911    1 ILLFLLFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 105 HSLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPL 184
Cdd:cd15911   81 GSLAATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 185 LKLACTDASVI-LVQDVIHALAILITSLIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRFSA 263
Cdd:cd15911  161 LKLSCSDTSLVeLVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPST 240

                        250       260       270
                 ....*....|....*....|....*....|
gi 384551642 264 TYTPFWDNTIALTFSVFAPLFNPIIYSLRN 293
Cdd:cd15911  241 NTSRDLNKVFSLFYTVLTPLVNPLIYSLRN 270

7tmA_OR5-like

cd15230

olfactory receptor family 5 and related proteins, member of the class A family of ...

28-293

4.92e-99

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320358 Cd Length: 270 Bit Score: 292.49 E-value: 4.92e-99

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  28 FFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFHSL 107
Cdd:cd15230    4 FVLFLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFAVF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 108 GNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPLLKL 187
Cdd:cd15230   84 GTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 188 ACTDASVI-LVQDVIHALAILITSLIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRFSATYT 266
Cdd:cd15230  164 SCSDTHINeLVLFAFSGFIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSSSYS 243

                        250       260
                 ....*....|....*....|....*..
gi 384551642 267 PFWDNTIALTFSVFAPLFNPIIYSLRN 293
Cdd:cd15230  244 LDQDKVVSVFYTVVIPMLNPLIYSLRN 270

7tmA_OR11G-like

cd15913

olfactory receptor OR11G and related proteins, member of the class A family of ...

25-293

7.28e-96

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320579 Cd Length: 270 Bit Score: 284.21 E-value: 7.28e-96

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  25 LLYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFF 104
Cdd:cd15913    1 ILLFSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 105 HSLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPL 184
Cdd:cd15913   81 FSLGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 185 LKLACTDASVI-LVQDVIHALAILITSLIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRFSA 263
Cdd:cd15913  161 LALSCVPAPGTeLICYTLSSLIIFGTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGS 240

                        250       260       270
                 ....*....|....*....|....*....|
gi 384551642 264 TYTPFWDNTIALTFSVFAPLFNPIIYSLRN 293
Cdd:cd15913  241 GNSTGMQKIVTLFYSVVTPLLNPLIYSLRN 270

7tmA_OR5AK3-like

cd15408

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...

9-297

3.63e-95

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320530 Cd Length: 287 Bit Score: 283.06 E-value: 3.63e-95

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642   9 VTVFVFTGFPQLKnggLLYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISE 88
Cdd:cd15408    1 FILLGFTDQPELQ---VLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAE 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  89 QKTISFIGCLLQMYFFHSLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPF 168
Cdd:cd15408   78 RKVISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSF 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 169 CGPNQITQIFCDFTPLLKLACTDASV-ILVQDVIHALAILITSLIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVF 247
Cdd:cd15408  158 CGSNVINHFFCDGPPLLALSCSDTSLnEMLLFAFVGFNVLTTTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAV 237

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 384551642 248 LLFFGSVALMYLRFSATYTPFWDNTIALTFSVFAPLFNPIIYSLRNKDMK 297
Cdd:cd15408  238 TLFYGSLAFMYLRPSSRYSLDLDKVASVFYTVVIPMLNPLIYSLRNKEVK 287

7tmA_OR5AP2-like

cd15943

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...

14-304

1.30e-94

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320609 [Multi-domain] Cd Length: 295 Bit Score: 281.95 E-value: 1.30e-94

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  14 FTGFPQLKnggLLYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTIS 93
Cdd:cd15943    7 LTDNPELQ---VILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENKTIS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  94 FIGCLLQMYFFHSLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQ 173
Cdd:cd15943   84 FTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCGSNV 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 174 ITQIFCDFTPLLKLACTDASVILVqdVIHALAILI---TSLIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLF 250
Cdd:cd15943  164 INHFFCDVPPLLKLSCSDTHVNEI--VLFAFAIFLgifTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTIF 241

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 384551642 251 FGSVALMYLRFSATYTPFWDNTIALTFSVFAPLFNPIIYSLRNKDMKDAINKLI 304
Cdd:cd15943  242 YGTTLFMYLRPSSSYSLDQDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRIL 295

7tmA_OR2-like

cd15237

olfactory receptor family 2 and related proteins, member of the class A family of ...

25-293

1.75e-94

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320365 [Multi-domain] Cd Length: 270 Bit Score: 280.70 E-value: 1.75e-94

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  25 LLYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFF 104
Cdd:cd15237    1 ILLFILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 105 HSLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPL 184
Cdd:cd15237   81 LALGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 185 LKLACTDASVILVqdVIHALAILITSL---IISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRF 261
Cdd:cd15237  161 LKLACADTSLNEA--VIFVTSVLVLLIpfsLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRP 238

                        250       260       270
                 ....*....|....*....|....*....|..
gi 384551642 262 SATYTPFWDNTIALTFSVFAPLFNPIIYSLRN 293
Cdd:cd15237  239 HSTHSPDQDKMISVFYTIVTPMLNPLIYSLRN 270

7tmA_OR5A1-like

cd15417

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...

26-302

1.50e-93

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320539 Cd Length: 279 Bit Score: 278.76 E-value: 1.50e-93

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  26 LYFFPL-LFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFF 104
Cdd:cd15417    1 IILFVLfLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 105 HSLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPL 184
Cdd:cd15417   81 SGMGLTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 185 LKLACTDASVILVqdVIHALAILI---TSLIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRF 261
Cdd:cd15417  161 LSLSCSDTFISQV--VLFLVAVLFgvfSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRP 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 384551642 262 SATYTPFWDNTIALTFSVFAPLFNPIIYSLRNKDMKDAINK 302
Cdd:cd15417  239 SSSHSQDQDKVASVFYTVVIPMLNPLIYSLRNKEIKDALKR 279

7tmA_OR8S1-like

cd15229

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...

28-300

1.59e-91

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320357 [Multi-domain] Cd Length: 277 Bit Score: 273.70 E-value: 1.59e-91

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  28 FFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFHSL 107
Cdd:cd15229    4 FLVFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFFF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 108 GNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPLLKL 187
Cdd:cd15229   84 AGTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLLPL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 188 ACTDAS----VILVQDVIHAlaiLITSLIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRFSA 263
Cdd:cd15229  164 SCSDTFankmVLLTSSVIFG---LGSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNS 240

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 384551642 264 TYTPFWDNTIALTFSVFAPLFNPIIYSLRNKDMKDAI 300
Cdd:cd15229  241 ASSSVLDRVFSIQYSILTPMLNPIIYSLKNKEVKAAL 277

7tmA_OR1_7-like

cd15918

olfactory receptor families 1, 7, and related proteins, member of the class A family of ...

28-293

7.18e-91

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320584 [Multi-domain] Cd Length: 270 Bit Score: 271.79 E-value: 7.18e-91

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  28 FFPL-LFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFHS 106
Cdd:cd15918    3 LFGLfLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 107 LGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPLLK 186
Cdd:cd15918   83 FGDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPLLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 187 LACTDASV-ILVQDVIHALAILITSLIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRFSATY 265
Cdd:cd15918  163 LSCSDTHLnELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPSSH 242

                        250       260
                 ....*....|....*....|....*...
gi 384551642 266 TPFWDNTIALTFSVFAPLFNPIIYSLRN 293
Cdd:cd15918  243 SASKDSVAAVMYTVVTPMLNPFIYSLRN 270

7tmA_OR2T-like

cd15421

olfactory receptor subfamily 2T and related proteins, member of the class A family of ...

25-299

2.60e-90

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320543 Cd Length: 277 Bit Score: 270.58 E-value: 2.60e-90

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  25 LLYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFF 104
Cdd:cd15421    1 LFLFSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 105 HSLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPL 184
Cdd:cd15421   81 LTLGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 185 LKLACTDASVI-LVQDVIHALAILITSLIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRFSA 263
Cdd:cd15421  161 LKLSCADTSAYeTVVYVSGVLFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGS 240

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 384551642 264 TYTPFWDNTIALTFSVFAPLFNPIIYSLRNKDMKDA 299
Cdd:cd15421  241 YHSPEQDKVVSVFYTILTPMLNPLIYSLRNKEVLGA 276

7tmA_OR14-like

cd15227

olfactory receptor family 14 and related proteins, member of the class A family of ...

25-293

2.53e-89

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320355 Cd Length: 270 Bit Score: 267.78 E-value: 2.53e-89

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  25 LLYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFF 104
Cdd:cd15227    1 ILHFVLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 105 HSLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPL 184
Cdd:cd15227   81 IFFAASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 185 LKLACTDasVILVQDVIHALAILITS---LIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRF 261
Cdd:cd15227  161 LKLSCSD--TYLNEIGVLVLSVCLGLgcfVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKP 238

                        250       260       270
                 ....*....|....*....|....*....|..
gi 384551642 262 SATYTPFWDNTIALTFSVFAPLFNPIIYSLRN 293
Cdd:cd15227  239 PSDSPSLLDLLLSVFYSVVPPTLNPIIYSLRN 270

7tmA_OR8H-like

cd15411

olfactory receptor subfamily 8H and related proteins, member of the class A family of ...

28-302

4.20e-88

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320533 [Multi-domain] Cd Length: 279 Bit Score: 264.95 E-value: 4.20e-88

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  28 FFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFHSL 107
Cdd:cd15411    4 FVLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFIAL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 108 GNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPLLKL 187
Cdd:cd15411   84 ATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPLLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 188 ACTDASVI-LVQDVIHALAILITSLIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRFSATYT 266
Cdd:cd15411  164 SCSDTHVNeMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSSSYS 243

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 384551642 267 PFWDNTIALTFSVFAPLFNPIIYSLRNKDMKDAINK 302
Cdd:cd15411  244 LGQDKVASVFYTVVIPMLNPLIYSLRNKEVKNALRR 279

7tmA_OR9K2-like

cd15419

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...

25-302

1.14e-87

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320541 Cd Length: 279 Bit Score: 263.79 E-value: 1.14e-87

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  25 LLYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFF 104
Cdd:cd15419    1 VLLFLLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 105 HSLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPL 184
Cdd:cd15419   81 SLFGTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 185 LKLACTDASV-ILVQDVIHALAILITSLIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRFSA 263
Cdd:cd15419  161 LKLSCSDTFInELVMFVLCGLIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGA 240

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 384551642 264 TYTPFWDNTIALTFSVFAPLFNPIIYSLRNKDMKDAINK 302
Cdd:cd15419  241 VSSPEQSKVVSVFYTLVIPMLNPLIYSLRNKDVKEALKR 279

7tmA_OR2F-like

cd15429

olfactory receptor subfamily 2F and related proteins, member of the class A family of ...

28-299

1.71e-87

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320546 [Multi-domain] Cd Length: 277 Bit Score: 263.49 E-value: 1.71e-87

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  28 FFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFHSL 107
Cdd:cd15429    4 FVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLAL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 108 GNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPLLKL 187
Cdd:cd15429   84 GGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVRL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 188 ACTDASVILVQDVIHALAILITS-LIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRFSATYT 266
Cdd:cd15429  164 ACVDTSLNEVAILVSSVVVLLTPcFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSGSS 243

                        250       260       270
                 ....*....|....*....|....*....|...
gi 384551642 267 PFWDNTIALTFSVFAPLFNPIIYSLRNKDMKDA 299
Cdd:cd15429  244 ALQEKMISLFYAVVTPMLNPLIYSLRNKEVKGA 276

7tmA_OR13-like

cd15430

olfactory receptor family 13 and related proteins, member of the class A family of ...

26-293

3.36e-86

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320547 [Multi-domain] Cd Length: 270 Bit Score: 259.61 E-value: 3.36e-86

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  26 LYFFPL-LFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFF 104
Cdd:cd15430    1 ILLFVLcLIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 105 HSLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPL 184
Cdd:cd15430   81 LAMGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 185 LKLACTDASV-ILVQDVIHALAILITSLIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRFSA 263
Cdd:cd15430  161 LKLACVDISLnEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKS 240

                        250       260       270
                 ....*....|....*....|....*....|
gi 384551642 264 TYTPFWDNTIALTFSVFAPLFNPIIYSLRN 293
Cdd:cd15430  241 KNAQISDKLITLFYGVVTPMLNPIIYSLRN 270

7tmA_OR5D-like

cd15410

olfactory receptor subfamily 5D and related proteins, member of the class A family of ...

12-304

3.64e-86

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320532 Cd Length: 294 Bit Score: 260.67 E-value: 3.64e-86

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  12 FVFTGFPQLKNGGLLYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKT 91
Cdd:cd15410    1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  92 ISFIGCLLQMYFFHSLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGP 171
Cdd:cd15410   81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 172 NQITQIFCDFTPLLKLACTDASVILVQDVIHALAILITSLIISL-SYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLF 250
Cdd:cd15410  161 NVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILtSYVFIIVTILRIRSAEGRQKAFSTCASHLTAITIF 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 384551642 251 FGSVALMYLRFSATYTPFWDNTIALTFSVFAPLFNPIIYSLRNKDMKDAINKLI 304
Cdd:cd15410  241 HGTILFMYCRPSSSYSLDTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKLI 294

7tmA_OR12D-like

cd15915

olfactory receptor subfamily 12D and related proteins, member of the class A family of ...

28-293

4.46e-86

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320581 [Multi-domain] Cd Length: 271 Bit Score: 259.55 E-value: 4.46e-86

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  28 FFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFHSL 107
Cdd:cd15915    4 FVLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHFL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 108 GNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPLLKL 187
Cdd:cd15915   84 GSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 188 ACTDASVIL-VQDVIHALAILITSLIISLSYIRIIVVILSIS-STEGRKKAFSTCAAHIAVFLLFFGSVALMYLRFSATY 265
Cdd:cd15915  164 ACGDTSLNLwLLNIVTGSIALGTFILTLLSYIYIISFLLLKVrSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSSGD 243

                        250       260
                 ....*....|....*....|....*...
gi 384551642 266 TPFWDNTIALTFSVFAPLFNPIIYSLRN 293
Cdd:cd15915  244 SLEQDRIVALLYTVVTPVLNPLIYTLRN 271

7tmA_OR2A-like

cd15420

olfactory receptor subfamily 2A and related proteins, member of the class A family of ...

25-299

5.58e-86

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320542 [Multi-domain] Cd Length: 277 Bit Score: 259.57 E-value: 5.58e-86

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  25 LLYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFF 104
Cdd:cd15420    1 LLLFGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 105 HSLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPL 184
Cdd:cd15420   81 LALAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 185 LKLACTDASVILVQDVIHALAILITSLIISL-SYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRFSA 263
Cdd:cd15420  161 LKLACADTWINEILIFAGCVFILLGPFSLILiSYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGS 240

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 384551642 264 TYTPFWDNTIALTFSVFAPLFNPIIYSLRNKDMKDA 299
Cdd:cd15420  241 SNSAEQEKILSLFYSLFNPMLNPLIYSLRNKQVKGA 276

7tmA_OR5H-like

cd15409

olfactory receptor subfamily 5H and related proteins, member of the class A family of ...

26-302

1.44e-84

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320531 [Multi-domain] Cd Length: 279 Bit Score: 255.80 E-value: 1.44e-84

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  26 LYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFH 105
Cdd:cd15409    2 PLFLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 106 SLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPLL 185
Cdd:cd15409   82 FSATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 186 KLACTDASV-ILVQDVIHALAILITSLIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRFSAT 264
Cdd:cd15409  162 KISCTDPSInELVLFIFSGSIQVFTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSL 241

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 384551642 265 YTPFWDNTIALTFSVFAPLFNPIIYSLRNKDMKDAINK 302
Cdd:cd15409  242 YALDQDMMDSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279

7tmA_OR13H-like

cd15431

olfactory receptor subfamily 13H and related proteins, member of the class A family of ...

26-293

2.25e-84

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320548 [Multi-domain] Cd Length: 269 Bit Score: 255.23 E-value: 2.25e-84

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  26 LYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFH 105
Cdd:cd15431    2 ILFVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 106 SLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLI-LLPEIVWIstLPFCGPNQITQIFCDFTPL 184
Cdd:cd15431   82 FLGITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLtVIPVLTMP--LHFCGPNVINHFFCEVQAL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 185 LKLACTDASVI-LVQDVIHALAILITSLIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRFSA 263
Cdd:cd15431  160 LKLACSDTSLNeILMFATSIFTLLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQS 239

                        250       260       270
                 ....*....|....*....|....*....|
gi 384551642 264 TYTPFWDNTIALTFSVFAPLFNPIIYSLRN 293
Cdd:cd15431  240 KSSSDQDKIISVFYGVVTPMLNPLIYSLRN 269

7tmA_OR5P-like

cd15416

olfactory receptor subfamily 5P and related proteins, member of the class A family of ...

28-302

1.37e-83

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320538 [Multi-domain] Cd Length: 279 Bit Score: 253.44 E-value: 1.37e-83

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  28 FFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFHSL 107
Cdd:cd15416    4 FVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAATF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 108 GNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPLLKL 187
Cdd:cd15416   84 GTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPLLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 188 ACTDASVI-LVQDVIHALAILITSLIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRFSATYT 266
Cdd:cd15416  164 SCSDIRLAkILPSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNSSYS 243

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 384551642 267 PFWDNTIALTFSVFAPLFNPIIYSLRNKDMKDAINK 302
Cdd:cd15416  244 MDQNKVVSVFYMVVIPMLNPLIYSLRNKEVKGALKR 279

7tmA_OR5M-like

cd15412

olfactory receptor subfamily 5M and related proteins, member of the class A family of ...

25-302

2.61e-83

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320534 Cd Length: 279 Bit Score: 252.70 E-value: 2.61e-83

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  25 LLYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFF 104
Cdd:cd15412    1 PLLFVLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 105 HSLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPL 184
Cdd:cd15412   81 IALVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 185 LKLACTDASVILVQDVIHALAILITSL-IISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRFSA 263
Cdd:cd15412  161 IKLSCSDTYVKETAMFIVAGFNLSSSLlIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPS 240

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 384551642 264 TYTPFWDNTIALTFSVFAPLFNPIIYSLRNKDMKDAINK 302
Cdd:cd15412  241 EESVEQSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279

7tmA_OR2_unk

cd15424

olfactory receptor family 2, unknown subfamily, member of the class A family of ...

25-300

3.70e-83

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320544 [Multi-domain] Cd Length: 277 Bit Score: 252.35 E-value: 3.70e-83

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  25 LLYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFF 104
Cdd:cd15424    1 ILLFVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 105 HSLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPL 184
Cdd:cd15424   81 LSLGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 185 LKLACTDASVilVQDVIHALAILITSL---IISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRF 261
Cdd:cd15424  161 LKLACADTHI--TEAIVFGAGVLILLVplsVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRP 238

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 384551642 262 SATYTPFWDNTIALTFSVFAPLFNPIIYSLRNKDMKDAI 300
Cdd:cd15424  239 RSGSTPDRDKQIAVFYIVITPLLNPIIYTLRNKDVHGAA 277

7tmA_OR1330-like

cd15946

olfactory receptor 1330 and related proteins, member of the class A family of ...

25-293

2.16e-81

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320612 Cd Length: 270 Bit Score: 247.39 E-value: 2.16e-81

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  25 LLYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFF 104
Cdd:cd15946    1 SILFAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 105 HSLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPL 184
Cdd:cd15946   81 LALGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 185 LKLACTDASVILVQDVIHALAILITSL-IISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRFSA 263
Cdd:cd15946  161 LKLACADTSLNEMVDFVLGVIVLVVPLsLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGS 240

                        250       260       270
                 ....*....|....*....|....*....|
gi 384551642 264 TYTPFWDNTIALTFSVFAPLFNPIIYSLRN 293
Cdd:cd15946  241 NYSPERDKKISLFYNVFTALLNPVIYSLRN 270

7tmA_OR2B-like

cd15947

olfactory receptor subfamily 2B and related proteins, member of the class A family of ...

28-293

2.72e-81

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320613 [Multi-domain] Cd Length: 270 Bit Score: 247.15 E-value: 2.72e-81

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  28 FFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFHSL 107
Cdd:cd15947    4 FVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFLWL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 108 GNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPLLKL 187
Cdd:cd15947   84 GSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPALIKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 188 ACTDASVILVQDVIHALAILITSL-IISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRFSATYT 266
Cdd:cd15947  164 ACVDTTFNELELFVASVFFLLVPLsLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPSSYS 243

                        250       260
                 ....*....|....*....|....*..
gi 384551642 267 PFWDNTIALTFSVFAPLFNPIIYSLRN 293
Cdd:cd15947  244 QDQGKFISLFYTVVTPTLNPLIYTLRN 270

7tmA_OR5C1-like

cd15945

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...

12-302

4.24e-81

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320611 Cd Length: 292 Bit Score: 247.74 E-value: 4.24e-81

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  12 FVFTGFPQLKNGGLLYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKT 91
Cdd:cd15945    1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  92 ISFIGCLLQMYFFHSLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGP 171
Cdd:cd15945   81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 172 NQITQIFCDFTPLLKLACTDASVI-LVQDVIHALAILITSLIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLF 250
Cdd:cd15945  161 NTINHFFCDIPPLLALSCSDTQINeLLLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLF 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 384551642 251 FGSVALMYLRFSATYTPFWDNTIALTFSVFAPLFNPIIYSLRNKDMKDAINK 302
Cdd:cd15945  241 YGTLLFMYLRPSSSYSLDTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292

7tmA_OR8D-like

cd15406

olfactory receptor subfamily 8D and related proteins, member of the class A family of ...

28-304

2.02e-80

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320528 [Multi-domain] Cd Length: 290 Bit Score: 245.74 E-value: 2.02e-80

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  28 FFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFHSL 107
Cdd:cd15406   13 FLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYPECMTQLFFFCVF 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 108 GNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPLLKL 187
Cdd:cd15406   93 AIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVINHYFCDILPLLKL 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 188 ACTDASVI-LVQDVIHALAILITSLIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRFSATYT 266
Cdd:cd15406  173 SCSSTYINeLLLFIVGGFNVLATTLAILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSIIFMYLKPSSSSS 252

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 384551642 267 PFWDNTIALTFSVFAPLFNPIIYSLRNKDMKDAINKLI 304
Cdd:cd15406  253 MTQEKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKVL 290

7tmA_OR9G-like

cd15418

olfactory receptor subfamily 9G and related proteins, member of the class A family of ...

25-303

2.15e-80

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320540 [Multi-domain] Cd Length: 281 Bit Score: 245.46 E-value: 2.15e-80

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  25 LLYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFF 104
Cdd:cd15418    2 LILFVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFFS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 105 HSLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPL 184
Cdd:cd15418   82 AGLAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPPL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 185 LKLACTDASVI-LVQDVIHALAILITSLIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRFSA 263
Cdd:cd15418  162 VKLACDDTRVYeLILYFILGFNVIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPSS 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 384551642 264 TYTPFWDNTIALTFSVFAPLFNPIIYSLRNKDMKDAINKL 303
Cdd:cd15418  242 SHTPDRDKVVALFYTVVNPLLNPLIYSLRNKDVKEALKKL 281

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

28-293

8.70e-80

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 243.27 E-value: 8.70e-80

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  28 FFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFHSL 107
Cdd:cd15939    4 FVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEHFF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 108 GNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPLLKL 187
Cdd:cd15939   84 GGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 188 ACTDASVILVQDVIHALAI-LITSLIISLSYIrIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRFSATYT 266
Cdd:cd15939  164 ACTDTYVIGLLVVANSGLIcLLSFLILLISYI-VILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTTFP 242

                        250       260
                 ....*....|....*....|....*..
gi 384551642 267 PfwDNTIALTFSVFAPLFNPIIYSLRN 293
Cdd:cd15939  243 I--DKVVAVFYTIITPMLNPLIYTLRN 267

7tmA_OR5J-like

cd15415

olfactory receptor subfamily 5J and related proteins, member of the class A family of ...

28-302

1.12e-78

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320537 [Multi-domain] Cd Length: 279 Bit Score: 240.78 E-value: 1.12e-78

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  28 FFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFHSL 107
Cdd:cd15415    4 FMLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAVF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 108 GNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPLLKL 187
Cdd:cd15415   84 VTTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 188 ACTDASVILVQDVIHALAI-LITSLIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRFSATYT 266
Cdd:cd15415  164 SCSDTHINELLLLTFSGVIaMSTLLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSQYS 243

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 384551642 267 PFWDNTIALTFSVFAPLFNPIIYSLRNKDMKDAINK 302
Cdd:cd15415  244 LEQEKVSAVFYTLVIPMLNPLIYSLRNKDVKDALKR 279

7tmA_OR10G-like

cd15916

olfactory receptor subfamily 10G and related proteins, member of the class A family of ...

26-300

1.47e-78

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320582 [Multi-domain] Cd Length: 276 Bit Score: 240.43 E-value: 1.47e-78

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  26 LYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQ-KTISFIGCLLQMYFF 104
Cdd:cd15916    2 LLFLIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEPGgKVISFGGCVAQLYFF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 105 HSLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPL 184
Cdd:cd15916   82 HFLGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 185 LKLACTDAS----VILVQDVIHALAILItslIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLR 260
Cdd:cd15916  162 LKLACADTTinelVIFASIGVVALGCFI---LILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLR 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 384551642 261 fsATYTPFWDNTIALTFSVFAPLFNPIIYSLRNKDMKDAI 300
Cdd:cd15916  239 --PGSKEALDGVIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276

7tmA_OR8K-like

cd15413

olfactory receptor subfamily 8K and related proteins, member of the class A family of ...

28-302

2.67e-78

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320535 Cd Length: 279 Bit Score: 239.92 E-value: 2.67e-78

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  28 FFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFHSL 107
Cdd:cd15413    4 FGLFLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLTF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 108 GNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPLLKL 187
Cdd:cd15413   84 IISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLLAL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 188 ACTDASVILVQDVIHALAILITSLIISL-SYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRFSATYT 266
Cdd:cd15413  164 SCSDTHEKELIILIFAGFNLISSLLIVLvSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKSSHS 243

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 384551642 267 PFWDNTIALTFSVFAPLFNPIIYSLRNKDMKDAINK 302
Cdd:cd15413  244 LDTDKMASVFYTLVIPMLNPLIYSLRNKEVKDALKK 279

7tmA_OR5G-like

cd15414

olfactory receptor subfamily 5G and related proteins, member of the class A family of ...

28-304

4.15e-78

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320536 [Multi-domain] Cd Length: 285 Bit Score: 239.64 E-value: 4.15e-78

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  28 FFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFHSL 107
Cdd:cd15414    4 FLLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFGLF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 108 GNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPLLKL 187
Cdd:cd15414   84 VAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPLLSL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 188 ACTDASVILVQDVIHALAILITS-LIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRFSATYT 266
Cdd:cd15414  164 SCADTQINKWVLFIMAGALGVLSgLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSSSSS 243

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 384551642 267 PFWDNTIALTFSVFAPLFNPIIYSLRNKDMKDAINKLI 304
Cdd:cd15414  244 LDLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRRTI 281

7tmA_OR10D-like

cd15228

olfactory receptor subfamily 10D and related proteins, member of the class A family of ...

28-300

4.22e-78

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320356 [Multi-domain] Cd Length: 275 Bit Score: 239.26 E-value: 4.22e-78

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  28 FFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFHSL 107
Cdd:cd15228    4 FVLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHFL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 108 GNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPLLKL 187
Cdd:cd15228   84 GSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 188 ACTDASVI-LVQDVIHALAILITSLIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRfsATYT 266
Cdd:cd15228  164 ACADTSIAeTVSFTNVGLVPLTCFLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQ--PTPS 241

                        250       260       270
                 ....*....|....*....|....*....|....
gi 384551642 267 PFWDNTIALTFSVFAPLFNPIIYSLRNKDMKDAI 300
Cdd:cd15228  242 PVLVTPVQIFNNVVTPMLNPLIYTLRNKEVKAAL 275

7tmA_OR4-like

cd15226

olfactory receptor family 4 and related proteins, member of the class A family of ...

25-293

1.28e-77

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320354 [Multi-domain] Cd Length: 267 Bit Score: 237.87 E-value: 1.28e-77

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  25 LLYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFF 104
Cdd:cd15226    1 LFLFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 105 HSLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPL 184
Cdd:cd15226   81 HFFGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 185 LKLACTDASVILVQDVIHALAI-LITSLIISLSYIRIIVVILSISStEGRKKAFSTCAAHIAVFLLFFGSVALMYLR-FS 262
Cdd:cd15226  161 IKLACTDTYVLELMVVANSGLIsLVCFLLLLISYIVILVTVRKHSS-GGSSKALSTCSAHITVVVLFFGPCIFIYVWpFS 239

                        250       260       270
                 ....*....|....*....|....*....|.
gi 384551642 263 ATYTpfwDNTIALTFSVFAPLFNPIIYSLRN 293
Cdd:cd15226  240 TFPV---DKFLAVFYTVITPLLNPIIYTLRN 267

7tmA_OR7-like

cd15234

olfactory receptor family 7 and related proteins, member of the class A family of ...

26-300

4.09e-77

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320362 [Multi-domain] Cd Length: 277 Bit Score: 236.70 E-value: 4.09e-77

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  26 LYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFH 105
Cdd:cd15234    2 LLFGLFLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 106 SLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPLL 185
Cdd:cd15234   82 LFGGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 186 KLACTDASV-ILVQDVIHALAILITSLIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRFSAT 264
Cdd:cd15234  162 KLACSDTLInNILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAVT 241

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 384551642 265 YTPfWDNTIA-LTFSVFAPLFNPIIYSLRNKDMKDAI 300
Cdd:cd15234  242 HSS-RKTAVAsVMYTVVTPMLNPFIYSLRNKDMKGAL 277

7tmA_OR13-like

cd15232

olfactory receptor family 13 and related proteins, member of the class A family of ...

25-293

7.38e-77

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320360 [Multi-domain] Cd Length: 270 Bit Score: 236.00 E-value: 7.38e-77

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  25 LLYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFF 104
Cdd:cd15232    1 VLLFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 105 HSLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPL 184
Cdd:cd15232   81 TWSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 185 LKLACTDASV----ILVQDVIhaLAILITSLIIsLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLR 260
Cdd:cd15232  161 LLLSCSDTSLneimAFVADVF--FGVGNFLLTL-TSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIR 237

                        250       260       270
                 ....*....|....*....|....*....|...
gi 384551642 261 FSATYTPFWDNTIALTFSVFAPLFNPIIYSLRN 293
Cdd:cd15232  238 PSSSYSPEKDKVVAVLYSVVTPTLNPLIYSLRN 270

7tmA_OR2B2-like

cd15432

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...

25-300

7.23e-76

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320549 [Multi-domain] Cd Length: 277 Bit Score: 233.52 E-value: 7.23e-76

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  25 LLYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFF 104
Cdd:cd15432    1 MVLFVVFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 105 HSLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPL 184
Cdd:cd15432   81 LGLGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 185 LKLACTDASVILVQ-DVIHALAILITSLIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRFSA 263
Cdd:cd15432  161 LKLSCVDTTANEAElFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPS 240

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 384551642 264 TYTPFWDNTIALTFSVFAPLFNPIIYSLRNKDMKDAI 300
Cdd:cd15432  241 NSSHDRGKMVALFYGIITPMLNPLIYTLRNKDVKEAL 277

7tmA_OR2D-like

cd15428

olfactory receptor subfamily 2D and related proteins, member of the class A family of ...

25-300

1.78e-75

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320545 [Multi-domain] Cd Length: 277 Bit Score: 232.76 E-value: 1.78e-75

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  25 LLYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFF 104
Cdd:cd15428    1 ILLFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 105 HSLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPL 184
Cdd:cd15428   81 LSFGITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 185 LKLACTDA-SVILVQDVIHALAILITSLIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRFSA 263
Cdd:cd15428  161 LKLASTDThQAEMAMFIMCVFTLVLPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKS 240

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 384551642 264 TYTPFWDNTIALTFSVFAPLFNPIIYSLRNKDMKDAI 300
Cdd:cd15428  241 STSKEYDKMISVFYIIVTPMLNPLIYSLRNKEVKHAL 277

7tmA_OR5AR1-like

cd15944

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...

12-304

2.61e-74

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320610 [Multi-domain] Cd Length: 294 Bit Score: 230.44 E-value: 2.61e-74

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  12 FVFTGFPQLKNGGLLYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKT 91
Cdd:cd15944    1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  92 ISFIGCLLQMYFFHSLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGP 171
Cdd:cd15944   81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 172 NQITQIFCDFTPLLKLACTDASVI-LVQDVIHALAILITSLIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLF 250
Cdd:cd15944  161 NIINHFFCDVPPLLALSCSDTHINeILLYVFCGFVEMSSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTLF 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 384551642 251 FGSVALMYLRFSATYTPFWDNTIALTFSVFAPLFNPIIYSLRNKDMKDAINKLI 304
Cdd:cd15944  241 YGTVIFMYLRPTSVYSLDQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKLI 294

7tmA_OR4E-like

cd15940

olfactory receptor 4E and related proteins, member of the class A family of ...

25-293

1.78e-73

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320606 [Multi-domain] Cd Length: 267 Bit Score: 227.32 E-value: 1.78e-73

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  25 LLYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFF 104
Cdd:cd15940    1 LAFFMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 105 HSLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPL 184
Cdd:cd15940   81 HLFACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 185 LKLACTDASVILVQDVIHALAI-LITSLIISLSYIRIIVVILSIsSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRFSA 263
Cdd:cd15940  161 IKLACTDTYLIDILIVSNSGLIsLVCFVALLGSYIVILVSLRKR-STEGRRKALSTCASHLTVVTLFFGPCIFIYTRPST 239

                        250       260       270
                 ....*....|....*....|....*....|
gi 384551642 264 TYTPfwDNTIALTFSVFAPLFNPIIYSLRN 293
Cdd:cd15940  240 SFSE--DKVVSVFYTVVTPLLNPIIYTLRN 267

7tmA_OR2W-like

cd15434

olfactory receptor subfamily 2W and related proteins, member of the class A family of ...

31-300

1.66e-71

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320551 [Multi-domain] Cd Length: 277 Bit Score: 222.64 E-value: 1.66e-71

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  31 LLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFHSLGNT 110
Cdd:cd15434    7 VLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIALGLGGT 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 111 EGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGF---LILLPEIVwisTLPFCGPNQITQIFCDFTPLLKL 187
Cdd:cd15434   87 ECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFgnsLVLSPLTL---SLPRCGHHRVDHFFCEMPALIKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 188 ACTDASVILVQDVIHALAILITSLI-ISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRFSATYT 266
Cdd:cd15434  164 ACVDTTAYEATIFALGVFILLFPLSlILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKNSVS 243

                        250       260       270
                 ....*....|....*....|....*....|....
gi 384551642 267 PFWDNTIALTFSVFAPLFNPIIYSLRNKDMKDAI 300
Cdd:cd15434  244 QDQGKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277

7tmA_OR5B-like

cd15407

olfactory receptor subfamily 5B and related proteins, member of the class A family of ...

28-302

4.60e-71

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320529 Cd Length: 279 Bit Score: 221.53 E-value: 4.60e-71

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  28 FFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFHSL 107
Cdd:cd15407    4 FIIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVVF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 108 GNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPLLKL 187
Cdd:cd15407   84 ATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPVLAL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 188 ACTDASVI-LVQDVIHALAILITSLIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRFSATYT 266
Cdd:cd15407  164 SCSDIHISeIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSSSHS 243

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 384551642 267 PFWDNTIALTFSVFAPLFNPIIYSLRNKDMKDAINK 302
Cdd:cd15407  244 MDTDKMASVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279

7tmA_OR4D-like

cd15936

olfactory receptor 4D and related proteins, member of the class A family of ...

25-293

1.24e-70

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320602 [Multi-domain] Cd Length: 267 Bit Score: 219.90 E-value: 1.24e-70

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  25 LLYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFF 104
Cdd:cd15936    1 FFLFLVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 105 HSLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPL 184
Cdd:cd15936   81 HFTGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 185 LKLACTDASVILVQDVIHA-LAILITSLIISLSYIrIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRfsa 263
Cdd:cd15936  161 IKLACTDTFLLELLMVSNSgLVTLLIFFILLISYT-VILVKIRTHVTEGKRKALSTCASQITVVTLIFVPCIYIYAR--- 236

                        250       260       270
                 ....*....|....*....|....*....|.
gi 384551642 264 TYTPF-WDNTIALTFSVFAPLFNPIIYSLRN 293
Cdd:cd15936  237 PFQTFpMDKAVSVLYTVITPMLNPMIYTLRN 267

7tmA_OR3A-like

cd15233

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...

26-300

2.55e-70

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320361 [Multi-domain] Cd Length: 277 Bit Score: 219.66 E-value: 2.55e-70

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  26 LYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFH 105
Cdd:cd15233    2 VLFVTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 106 SLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPLL 185
Cdd:cd15233   82 LLAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLF 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 186 KLACT----DASVILVQDVIHALAILItslIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRF 261
Cdd:cd15233  162 QLSCSsthlNELLLFVFAFFMALAPCV---LIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRL 238

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 384551642 262 SATYTPFWDNTIALTFSVFAPLFNPIIYSLRNKDMKDAI 300
Cdd:cd15233  239 GSVYSSDKDKVIGILNTVLSPMLNPLIYSLRNKDVKGAL 277

7tmA_OR8B-like

cd15405

olfactory receptor subfamily 8B and related proteins, member of the class A family of ...

25-300

2.75e-68

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320527 [Multi-domain] Cd Length: 277 Bit Score: 214.20 E-value: 2.75e-68

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  25 LLYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFF 104
Cdd:cd15405    1 IPLFFLFLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 105 HSLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPL 184
Cdd:cd15405   81 CFFVISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 185 LKLACTDASVI-LVQDVIHALAILITSLIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRFSA 263
Cdd:cd15405  161 LQLSCTSTYVNeLVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSS 240

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 384551642 264 TYTPFWDNTIALTFSVFAPLFNPIIYSLRNKDMKDAI 300
Cdd:cd15405  241 VGSVNQGKVSSVFYTNVVPMLNPLIYSLRNKDVKLAL 277

7tmA_OR51-like

cd15222

olfactory receptor family 51 and related proteins, member of the class A family of ...

28-294

6.12e-67

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320350 Cd Length: 275 Bit Score: 210.82 E-value: 6.12e-67

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  28 FFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFHSL 107
Cdd:cd15222    4 SIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHTF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 108 GNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPLLKL 187
Cdd:cd15222   84 SFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVMKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 188 ACTDASVilvqDVIHALAILIT-----SLIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFG---SVALMYl 259
Cdd:cd15222  164 ACSDTRV----NSIYGLFVVLStmgldSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVpmiGLSMVH- 238

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 384551642 260 RFSATYTPFWDNTIALTFSVFAPLFNPIIYSLRNK 294
Cdd:cd15222  239 RFGKHASPLVHVLMANVYLLVPPVLNPIIYSVKTK 273

7tmA_OR1E-like

cd15236

olfactory receptor subfamily 1E and related proteins, member of the class A family of ...

26-300

7.98e-67

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320364 [Multi-domain] Cd Length: 277 Bit Score: 210.39 E-value: 7.98e-67

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  26 LYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFH 105
Cdd:cd15236    2 VFFALFLAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 106 SLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPLL 185
Cdd:cd15236   82 FFGCLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 186 KLACTDASVILVQDVIHALAILITSLI-ISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRFSAT 264
Cdd:cd15236  162 KLSCSSTSLNELVIFTEGGLLFVLPLLlILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSN 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 384551642 265 YTPFWDNTIALTFSVFAPLFNPIIYSLRNKDMKDAI 300
Cdd:cd15236  242 NSSDKDIVASVMYTVVTPMLNPFIYSLRNRDIKGAL 277

7tmA_OR10S1-like

cd15941

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...

25-300

2.53e-66

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320607 [Multi-domain] Cd Length: 277 Bit Score: 209.32 E-value: 2.53e-66

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  25 LLYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHN-PMYNFISIFSFLEMWYTTATIPKMLSNLIS-EQKTISFIGCLLQMY 102
Cdd:cd15941    1 SLFFLLFLLIYLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAGLLTlSGRTISFEGCVVQLY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 103 FFHSLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFT 182
Cdd:cd15941   81 AFHFLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 183 PLLKLACTDaSVILVQDVIHALAILITS--LIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLR 260
Cdd:cd15941  161 PVLKLACAD-TTINELVILANIGIVAAGcfLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQ 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 384551642 261 FSATYTPfwDNTIALTFSVFAPLFNPIIYSLRNKDMKDAI 300
Cdd:cd15941  240 PSSSQAG--AGAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277

7tmA_OR56-like

cd15223

olfactory receptor family 56 and related proteins, member of the class A family of ...

26-300

1.52e-64

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320351 [Multi-domain] Cd Length: 279 Bit Score: 204.83 E-value: 1.52e-64

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  26 LYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFH 105
Cdd:cd15223    2 WLSLPFLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 106 SLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPLL 185
Cdd:cd15223   82 FFTAMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 186 KLACTDASVILVQDVIHALAILITSLI-ISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYL--RFS 262
Cdd:cd15223  162 SLACGDTTINSIYGLAVAWLIVGSDIIlIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLtyRFG 241

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 384551642 263 ATYTPFWDNTIALTFSVFAPLFNPIIYSLRNKDMKDAI 300
Cdd:cd15223  242 KTIPPDVHVLLSVLYILIPPALNPIIYGVRTKEIRQGF 279

7tmA_OR10G6-like

cd15942

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...

25-300

2.43e-64

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320608 Cd Length: 275 Bit Score: 204.20 E-value: 2.43e-64

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  25 LLYFFplLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFF 104
Cdd:cd15942    3 LFLFF--LVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 105 HSLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPL 184
Cdd:cd15942   81 HFLGCAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAM 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 185 LKLACTDASVI-LVQDVIHALAILITSLIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRFSA 263
Cdd:cd15942  161 LKLACADTAFNeLVTFIDIGLVAMTCFLLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGS 240

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 384551642 264 TYTpfWDNTIALTFSVFAPLFNPIIYSLRNKDMKDAI 300
Cdd:cd15942  241 QDP--LDGVVAVFYTTVTPLLNPVIYTLRNKEMKDAL 275

7tmA_OR4Q2-like

cd15938

olfactory receptor 4Q2 and related proteins, member of the class A family of ...

26-293

5.16e-63

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320604 [Multi-domain] Cd Length: 265 Bit Score: 200.48 E-value: 5.16e-63

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  26 LYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFH 105
Cdd:cd15938    2 LLFALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 106 SLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPLL 185
Cdd:cd15938   82 FVGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 186 KLACTDASVI-LVQDVIHALAILITSLIISLSYIRIIVvilSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRFSAT 264
Cdd:cd15938  162 KLACTDTCVTeLLMVSNSGLISTVCFVVLVTSYTTILV---TIRSTEGRRKALSTCASHLMVVTLFFGPCIFIYARPFST 238

                        250       260
                 ....*....|....*....|....*....
gi 384551642 265 YTPfwDNTIALTFSVFAPLFNPIIYSLRN 293
Cdd:cd15938  239 FPV--DKHVSVLYNVITPMLNPLIYTLRN 265

7tmA_OR52I-like

cd15950

olfactory receptor subfamily 52I and related proteins, member of the class A family of ...

29-294

3.04e-61

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320616 Cd Length: 275 Bit Score: 196.10 E-value: 3.04e-61

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  29 FPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFHSLG 108
Cdd:cd15950    5 IPFCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFT 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 109 NTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPLLKLA 188
Cdd:cd15950   85 AVESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAVVKLA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 189 CTDASVILVQDVIHALAILIT-SLIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFF-GSVALMYL-RFSATY 265
Cdd:cd15950  165 CADPRPSSLYSITGSTLVVGTdSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYiPGLLSIYTqRFGQGV 244

                        250       260
                 ....*....|....*....|....*....
gi 384551642 266 TPFWDNTIALTFSVFAPLFNPIIYSLRNK 294
Cdd:cd15950  245 PPHTQVLLADLYLLVPPMLNPIIYGMRTK 273

7tmA_OR2Y-like

cd15433

olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...

30-300

2.80e-60

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320550 [Multi-domain] Cd Length: 277 Bit Score: 193.85 E-value: 2.80e-60

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  30 PLLFIYIFI-----VTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFF 104
Cdd:cd15433    1 PVLFVVVLIfylltLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFIS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 105 HSLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPL 184
Cdd:cd15433   81 LALGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 185 LKLACTDASVILVQDVIHALAILITSLIISL-SYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRFSA 263
Cdd:cd15433  161 LKLACGDDETTEVQMFVARVVILLLPAALILgSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIH 240

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 384551642 264 TYTPFWDNTIALTFSVFAPLFNPIIYSLRNKDMKDAI 300
Cdd:cd15433  241 RYSQAHGKFVSLFYTVMTPALNPLIYTLRNKDVKGAL 277

7tmA_OR52P-like

cd15953

olfactory receptor subfamily 52P and related proteins, member of the class A family of ...

29-294

2.05e-59

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341354 Cd Length: 275 Bit Score: 191.32 E-value: 2.05e-59

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  29 FPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFHSLG 108
Cdd:cd15953    5 IPFCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLS 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 109 NTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPLLKLA 188
Cdd:cd15953   85 IMESAVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAVVKLA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 189 CTDASVILVQDVIHALAILITSLI-ISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYL--RFSATY 265
Cdd:cd15953  165 CGDTTINRIYGLVVALLVVGLDLLlIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALFSFLthRFGQGI 244

                        250       260
                 ....*....|....*....|....*....
gi 384551642 266 TPFWDNTIALTFSVFAPLFNPIIYSLRNK 294
Cdd:cd15953  245 APHIHIILANLYLLVPPMLNPIIYGVKTK 273

7tmA_OR51_52-like

cd15917

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...

29-296

3.17e-59

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341351 Cd Length: 275 Bit Score: 190.96 E-value: 3.17e-59

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  29 FPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFHSLG 108
Cdd:cd15917    5 IPFCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFT 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 109 NTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPLLKLA 188
Cdd:cd15917   85 AMESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVKLA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 189 CTDASVILVQDVIHALAIL-ITSLIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYL--RFSATY 265
Cdd:cd15917  165 CGDTRVNSIYGLFVALLIVgFDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLthRFGHHV 244

                        250       260       270
                 ....*....|....*....|....*....|.
gi 384551642 266 TPFWDNTIALTFSVFAPLFNPIIYSLRNKDM 296
Cdd:cd15917  245 PPHVHILLANLYLLLPPMLNPIVYGVRTKQI 275

7tmA_OR4N-like

cd15937

olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...

25-293

6.78e-58

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320603 Cd Length: 267 Bit Score: 187.25 E-value: 6.78e-58

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  25 LLYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFF 104
Cdd:cd15937    1 LLLFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 105 HSLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPL 184
Cdd:cd15937   81 HFLGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 185 LKLACTDASVI-LVQDVIHALAILITSLIISLSYiRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRFSA 263
Cdd:cd15937  161 IKLACTNTYTVeLLMFSNSGLVILLCFLLLLISY-AFLLAKLRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPFR 239

                        250       260       270
                 ....*....|....*....|....*....|
gi 384551642 264 TYTpfWDNTIALTFSVFAPLFNPIIYSLRN 293
Cdd:cd15937  240 SFP--MDKVVAVFHTVIFPLLNPMIYTLRN 267

7tmA_OR4Q3-like

cd15935

olfactory receptor 4Q3 and related proteins, member of the class A family of ...

25-293

4.14e-57

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320601 [Multi-domain] Cd Length: 268 Bit Score: 185.35 E-value: 4.14e-57

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  25 LLYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHN-PMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYF 103
Cdd:cd15935    1 LLLFVLVLACYAAILLGNLLIVVTVHADPHLLQsPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 104 FHSLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTP 183
Cdd:cd15935   81 LHFLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQ 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 184 LLKLACTDASVILVQDVIHALAILITSLIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLR-FS 262
Cdd:cd15935  161 VIKLACMDTYVVEVLMVANSGLLSLVCFLVLLVSYGIILTTLRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRpFS 240

                        250       260       270
                 ....*....|....*....|....*....|.
gi 384551642 263 ATYTpfwDNTIALTFSVFAPLFNPIIYSLRN 293
Cdd:cd15935  241 SSSV---DKVASVFYTLITPALNPLIYTLRN 268

7tmA_OR52E-like

cd15952

olfactory receptor subfamily 52E and related proteins, member of the class A family of ...

29-294

5.31e-57

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320618 Cd Length: 274 Bit Score: 185.28 E-value: 5.31e-57

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  29 FPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFHSLG 108
Cdd:cd15952    5 FPFCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFT 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 109 NTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPLLKLA 188
Cdd:cd15952   85 GMESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAKLA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 189 CTDASVILVQDVIHALAILITSLIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYL--RFSATYT 266
Cdd:cd15952  165 CASIRINIIYGLFAISVLVLDVILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLthRFGHNIP 244

                        250       260
                 ....*....|....*....|....*...
gi 384551642 267 PFWDNTIALTFSVFAPLFNPIIYSLRNK 294
Cdd:cd15952  245 RYIHILLANLYVVLPPMLNPVIYGVRTK 272

7tmA_OR52R_52L-like

cd15951

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...

29-294

1.85e-55

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320617 Cd Length: 275 Bit Score: 181.39 E-value: 1.85e-55

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  29 FPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFHSLG 108
Cdd:cd15951    5 IPFCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFS 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 109 NTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPLLKLA 188
Cdd:cd15951   85 TMESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 189 CTDASVILVQDVIHALAILITSLI-ISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYL--RFSATY 265
Cdd:cd15951  165 CADTRVSRAYGLSVAFLVGGLDVIfIAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFLthRFGHNV 244

                        250       260
                 ....*....|....*....|....*....
gi 384551642 266 TPFWDNTIALTFSVFAPLFNPIIYSLRNK 294
Cdd:cd15951  245 PPHVHILIANVYLLVPPMLNPIIYGVRTK 273

7tmA_OR52B-like

cd15221

olfactory receptor subfamily 52B and related proteins, member of the class A family of ...

29-294

6.42e-53

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320349 Cd Length: 275 Bit Score: 174.79 E-value: 6.42e-53

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  29 FPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFHSLG 108
Cdd:cd15221    5 IPFCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 109 NTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPLLKLA 188
Cdd:cd15221   85 VTESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGIARLA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 189 CTDASVILVQDVIHALAILITSLI-ISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYL--RFSATY 265
Cdd:cd15221  165 CADITVNIWYGLTVALLTVGLDVVlIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLthRFGRHI 244

                        250       260
                 ....*....|....*....|....*....
gi 384551642 266 TPFWDNTIALTFSVFAPLFNPIIYSLRNK 294
Cdd:cd15221  245 PRHVHILLANLYVLVPPMLNPIVYGVKTK 273

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

33-305

1.94e-52

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 173.46 E-value: 1.94e-52

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642   33 FIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFHSLGNTEG 112
Cdd:pfam13853   3 LMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMES 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  113 TLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPLLKLACTDA 192
Cdd:pfam13853  83 AVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADI 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  193 SVILVQDVIHALAIL-ITSLIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYL--RFSATYTPFW 269
Cdd:pfam13853 163 KVNNIYGLFVVTSTFgIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMvhRFGHNVPPLL 242

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 384551642  270 DNTIALTFSVFAPLFNPIIYSLRNKDMKDAINKLIC 305
Cdd:pfam13853 243 QIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRMLL 278

7tmA_OR52K-like

cd15948

olfactory receptor subfamily 52K and related proteins, member of the class A family of ...

30-297

3.49e-51

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320614 [Multi-domain] Cd Length: 277 Bit Score: 170.47 E-value: 3.49e-51

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  30 PLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFHSLGN 109
Cdd:cd15948    7 PFCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSI 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 110 TEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPLLKLAC 189
Cdd:cd15948   87 MESAVLLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCEHMAVVKLAC 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 190 TDASVILVQDVIHALAILITSLI-ISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYL--RFSATYT 266
Cdd:cd15948  167 GDTRFNNIYGIAVALFIVGLDLMfIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTPVVLSSTmhRFARHVA 246

                        250       260       270
                 ....*....|....*....|....*....|.
gi 384551642 267 PFWDNTIALTFSVFAPLFNPIIYSLRNKDMK 297
Cdd:cd15948  247 PHVHILLANFYLLFPPMMNPIVYGVKTKQIR 277

7tmA_OR52M-like

cd15949

olfactory receptor subfamily 52M and related proteins, member of the class A family of ...

10-297

2.08e-48

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320615 Cd Length: 292 Bit Score: 163.41 E-value: 2.08e-48

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  10 TVFVFTGFPQLKNGGLLYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQ 89
Cdd:cd15949    2 STFILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  90 KTISFIGCLLQMYFFHSLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFC 169
Cdd:cd15949   82 NEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWY 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 170 GPNQITQIFCDFTPLLKLACTDASVI-LVQDVIHALAILITSLIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFL 248
Cdd:cd15949  162 RTNIIAHSYCEHMAVVGLACGDVSINnHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLATSEARLKTFGTCVSHVCAIL 241

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 384551642 249 LFFGSVALMYL--RFSATYTPFWDNTIALTFSVFAPLFNPIIYSLRNKDMK 297
Cdd:cd15949  242 AFYVPIAVSSLihRFGQNVPPPTHILLANFYLLIPPMLNPIVYGVRTKQIQ 292

7tmA_OR52W-like

cd15956

olfactory receptor subfamily 52W and related proteins, member of the class A family of ...

30-296

9.84e-44

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320622 [Multi-domain] Cd Length: 275 Bit Score: 150.78 E-value: 9.84e-44

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  30 PLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFHSLGN 109
Cdd:cd15956    6 PFCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHAFSA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 110 TEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPLLKLAC 189
Cdd:cd15956   86 MESGVLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVVKLAC 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 190 TDASVILVQDVIHALAILITSLI-ISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFF--GSVALMYLRFSATYT 266
Cdd:cd15956  166 GATTVDSLYGLALALFIGGGDVLfIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYipGLLSVLMHRFGHSVP 245

                        250       260       270
                 ....*....|....*....|....*....|
gi 384551642 267 PFWDNTIALTFSVFAPLFNPIIYSLRNKDM 296
Cdd:cd15956  246 SAAHVLLSNLYLLLPPALNPIVYGIRTKQI 275

7tmA_OR52N-like

cd15954

olfactory receptor subfamily 52N and related proteins, member of the class A family of ...

29-296

1.06e-43

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320620 Cd Length: 276 Bit Score: 150.74 E-value: 1.06e-43

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  29 FPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFHSLG 108
Cdd:cd15954    5 IPFCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFT 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 109 NTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPLLKLA 188
Cdd:cd15954   85 GMESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVKLA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 189 CTDASVILVQDVIHALAI-LITSLIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYL--RFSATY 265
Cdd:cd15954  165 CANIRVDAIYGLMVALLIgGFDILCISVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFahRFGGHH 244

                        250       260       270
                 ....*....|....*....|....*....|..
gi 384551642 266 -TPFWDNTIALTFSVFAPLFNPIIYSLRNKDM 296
Cdd:cd15954  245 iTPHIHIIMANLYLLLPPMMNPIVYGVKTKQI 276

7tmA_OR52A-like

cd15955

olfactory receptor subfamily 52A and related proteins, member of the class A family of ...

29-296

4.62e-36

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320621 [Multi-domain] Cd Length: 276 Bit Score: 131.04 E-value: 4.62e-36

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  29 FPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFHSLG 108
Cdd:cd15955    5 IPFCIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQ 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 109 NTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWIS-TLPFCGPNQITQIFCDFTPLLKL 187
Cdd:cd15955   85 AFESGILLAMALDRYVAICHPLRHSSILTPQVLLGIGVLVVVRAVVLIIPCPLLIKlRLHHFRSTVISHSYCEHMAVVKL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 188 ACTDASVILVQDVIHALAIL-ITSLIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYL--RFSAT 264
Cdd:cd15955  165 AADDVRVNKIYGLFVAFSILgFDIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFahRFGHH 244

                        250       260       270
                 ....*....|....*....|....*....|..
gi 384551642 265 YTPFWDNTIALTFSVFAPLFNPIIYSLRNKDM 296
Cdd:cd15955  245 VAPYVHILLSNLYLLVPPVLNPIVYGVKTKQI 276

7tm_1

pfam00001

7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...

41-289

1.83e-33

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.

Pssm-ID: 459624 [Multi-domain] Cd Length: 256 Bit Score: 123.56 E-value: 1.83e-33

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642   41 GNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKML-SNLISEQKTISFIGCLLQMYFFHSLGNTEGTLLTVMA 119
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLvYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  120 IDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNqitQIFCDFTPLLKLACTDASVIlvqd 199
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGN---VTVCFIDFPEDLSKPVSYTL---- 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  200 VIHALAILITSLIISLSYIRIIVVILSISSTEGR-------KKAFSTCAAHIAVFLLFFGSVALMYLRFSATYTP----F 268
Cdd:pfam00001 154 LISVLGFLLPLLVILVCYTLIIRTLRKSASKQKSsertqrrRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCelsrL 233

                         250       260
                  ....*....|....*....|...
gi 384551642  269 WDNTIALT--FSVFAPLFNPIIY 289
Cdd:pfam00001 234 LDKALSVTlwLAYVNSCLNPIIY 256

7tm_classA_rhodopsin-like

cd00637

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...

31-293

1.08e-17

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

Pssm-ID: 410626 [Multi-domain] Cd Length: 275 Bit Score: 81.18 E-value: 1.08e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  31 LLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFHSLGNT 110
Cdd:cd00637    5 YILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVSLLA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 111 EGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCDFTPLLKLact 190
Cdd:cd00637   85 SILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLTLSKAY--- 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 191 daSVILVqdvihALAILITSLIISLSYIRIIVVIL--------------SISSTEGRKKAFSTCAAHIAVFLL----FFG 252
Cdd:cd00637  162 --TIFLF-----VLLFLLPLLVIIVCYVRIFRKLRrhrrrirssssnssRRRRRRRERKVTKTLLIVVVVFLLcwlpYFI 234

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 384551642 253 SVALMYLRFSATYTPFWDNTIALTFSVFAPLFNPIIYSLRN 293
Cdd:cd00637  235 LLLLDVFGPDPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275

7tmA_amine_R-like

cd14967

amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

30-300

9.92e-15

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320098 [Multi-domain] Cd Length: 259 Bit Score: 72.60 E-value: 9.92e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  30 PLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFHSLGN 109
Cdd:cd14967    5 FLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDVLCCT 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 110 TEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITqifCDFTPllklac 189
Cdd:cd14967   85 ASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGWRDETQPSVVDCE---CEFTP------ 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 190 tDASVILVQDVIhalAILITSLIISLSYIRIIVVilsiSSTEgrKKAFSTCAAHIAVFLL----FFgsVALMYLRFSAT- 264
Cdd:cd14967  156 -NKIYVLVSSVI---SFFIPLLIMIVLYARIFRV----ARRE--LKAAKTLAIIVGAFLLcwlpFF--IIYLVSAFCPPd 223

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 384551642 265 YTPFWDNTIALTFSVFAPLFNPIIYSLRNKDMKDAI 300
Cdd:cd14967  224 CVPPILYAVFFWLGYLNSALNPIIYALFNRDFRRAF 259

7tmA_Adenosine_R

cd14968

adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...

25-299

4.64e-09

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.

Pssm-ID: 341316 [Multi-domain] Cd Length: 285 Bit Score: 56.49 E-value: 4.64e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  25 LLYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPkmLSNLISEQKTISFIGCLLQMYFF 104
Cdd:cd14968    1 AVYIVLEVLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIP--LAILISLGLPTNFHGCLFMACLV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 105 HSLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLI-LLPEIVWISTLPFCGPNQITQIFCDFTp 183
Cdd:cd14968   79 LVLTQSSIFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVgLTPMFGWNNGAPLESGCGEGGIQCLFE- 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 184 llklactdaSVI----LVQdVIHALAILITSLIISLSYIRIIVVIlsisSTEGRKKAFSTCAAH--------------IA 245
Cdd:cd14968  158 ---------EVIpmdyMVY-FNFFACVLVPLLIMLVIYLRIFRVI----RKQLRQIESLLRSRRsrstlqkevkaaksLA 223

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 384551642 246 VFLLFFgsvALMYLRFS----------ATYTPFWDNTIALTFSVFAPLFNPIIYSLRNKDMKDA 299
Cdd:cd14968  224 IILFLF---ALCWLPLHiincitlfcpECKVPKILTYIAILLSHANSAVNPIVYAYRIRKFRQT 284

7tmA_Octopamine_R

cd15063

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...

25-299

3.47e-08

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.

Pssm-ID: 320191 [Multi-domain] Cd Length: 266 Bit Score: 53.65 E-value: 3.47e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  25 LLYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFF 104
Cdd:cd15063    1 LISLLVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 105 HSLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPeivwistlPFCGPNQITQIFCDFTPL 184
Cdd:cd15063   81 VWMCTASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFVICFP--------PLVGWNDGKDGIMDYSGS 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 185 LKLACTDASVILVQDVIHAL--AILITSLIISLSYIRIIVVilsiSSTEgrKKAFSTCAAHIAVFLLFFGSVALMYLrfs 262
Cdd:cd15063  153 SSLPCTCELTNGRGYVIYSAlgSFYIPMLVMLFFYFRIYRA----ARME--TKAAKTVAIIVGCFIFCWLPFFTVYL--- 223

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 384551642 263 atYTPFWDNTIA-LTFSVFAPL------FNPIIYSLRNKDMKDA 299
Cdd:cd15063  224 --VRAFCEDCIPpLLFSVFFWLgycnsaLNPCIYALFSRDFRFA 265

7tmA_Opsins_type2_animals

cd14969

type 2 opsins in animals, member of the class A family of seven-transmembrane G ...

31-300

2.10e-07

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.

Pssm-ID: 381741 [Multi-domain] Cd Length: 284 Bit Score: 51.44 E-value: 2.10e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  31 LLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFHSLGNT 110
Cdd:cd14969    7 LSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAVTFLGLV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 111 EGTLLTVMAIDRYVAICNPLRYpNIMTPRLCAQLTAGSCVFGFLILLPEIV-WISTLPF-----CGPNQITQIFcdftpl 184
Cdd:cd14969   87 SISTLAALAFERYLVIVRPLKA-FRLSKRRALILIAFIWLYGLFWALPPLFgWSSYVPEgggtsCSVDWYSKDP------ 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 185 lklacTDASVILvqdVIHALAILITSLIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFFGSVALMYLRFSAT 264
Cdd:cd14969  160 -----NSLSYIV---SLFVFCFFLPLAIIIFCYYKIYRTLRKMSKRAARRKNSAITKRTKKAEKKVAKMVLVMIVAFLIA 231

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 384551642 265 YTPFW----------DNTIALTFSVFAPLF-------NPIIYSLRNKDMKDAI 300
Cdd:cd14969  232 WTPYAvvslyvsfggESTIPPLLATIPALFaksstiyNPIIYVFMNKQFRRAL 284

7tmA_EDG-like

cd14972

endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...

32-299

4.00e-07

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 341317 [Multi-domain] Cd Length: 275 Bit Score: 50.37 E-value: 4.00e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  32 LFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFHSLGNTE 111
Cdd:cd14972    6 IVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSVLLVSLTPSPATWLLRKGSLVLSLLASA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 112 GTLLtVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLI-LLPEIVWISTLPFCGpnQITQIFcdftPLLklacT 190
Cdd:cd14972   86 YSLL-AIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLaLLPVLGWNCVLCDQE--SCSPLG----PGL----P 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 191 DASVILVqdvihALAILITSLIISLSYIRIIVVILS--------------ISSTEGRKKAFsTCAAHIAVFLLFFGSVAL 256
Cdd:cd14972  155 KSYLVLI-----LVFFFIALVIIVFLYVRIFWCLWRhanaiaarqeaavpAQPSTSRKLAK-TVVIVLGVFLVCWLPLLI 228

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 384551642 257 MYLRFSATYTPFWDNTIALTFSVFAPL---FNPIIYSLRNKDMKDA 299
Cdd:cd14972  229 LLVLDVLCPSVCDIQAVFYYFLVLALLnsaINPIIYAFRLKEMRRA 274

7tmA_Adenosine_R_A2B

cd15069

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...

26-297

1.47e-06

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320197 [Multi-domain] Cd Length: 294 Bit Score: 48.78 E-value: 1.47e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  26 LYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSnlISEQKTISFIGCLLQMYFFH 105
Cdd:cd15069    2 TYVALELIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAIT--ISLGFCTDFHSCLFLACFVL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 106 SLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLI-LLPEIVWISTLPFC-----GPNQITQIFC 179
Cdd:cd15069   80 VLTQSSIFSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFGIgLTPFLGWNKAMSATnnstnPADHGTNHSC 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 180 DFtpllkLACTDASVILVQDVIHAL---AILITSLIISLSYIRIIVV---------ILSISSTEGRKK--AFSTCAAHIA 245
Cdd:cd15069  160 CL-----ISCLFENVVPMSYMVYFNffgCVLPPLLIMLVIYIKIFLVacrqlqrteLMDHSRTTLQREihAAKSLAIIVG 234

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 384551642 246 VFLLFFGSV-----ALMYLRFSATYTPFWDNTIALTFSVFAPLFNPIIYSLRNKDMK 297
Cdd:cd15069  235 IFALCWLPVhilncITLFQPEFSKSKPKWAMNVAILLSHANSVVNPIVYAYRNRDFR 291

7tmA_Adenosine_R_A2A

cd15068

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...

25-297

1.83e-06

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320196 [Multi-domain] Cd Length: 293 Bit Score: 48.78 E-value: 1.83e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  25 LLYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPkmLSNLISEQKTISFIGCLLQMYFF 104
Cdd:cd15068    1 SVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIP--FAITISTGFCAACHGCLFIACFV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 105 HSLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLI-LLPEIVWISTLP---------FCGPNQI 174
Cdd:cd15068   79 LVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIgLTPMLGWNNCGQpkegknhsqGCGEGQV 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 175 TQIFCDFTPLLKLACTDASVILVQDVIHALAILitsLIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFL-LFFGS 253
Cdd:cd15068  159 ACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVY---LRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLaIIVGL 235

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 384551642 254 VALMYLRF-----------SATYTPFWDNTIALTFSVFAPLFNPIIYSLRNKDMK 297
Cdd:cd15068  236 FALCWLPLhiincftffcpDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFR 290

7tmA_5-HT1_5_7

cd15064

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...

31-299

2.71e-06

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320192 [Multi-domain] Cd Length: 258 Bit Score: 47.71 E-value: 2.71e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  31 LLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCllqmYFFHSLGNT 110
Cdd:cd15064    7 LSLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWILGQVLC----DIWISLDVT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 111 EGTL----LTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTlpfcgPNQITQIFCdftpllk 186
Cdd:cd15064   83 CCTAsilhLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISLPPLFGWRT-----PDSEDPSEC------- 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 187 lactdasvILVQDVIHAL-----AILITSLIISLSYIRIIVVilsissTEGRKKAFSTCAAHIAVFLL----FFGSVALM 257
Cdd:cd15064  151 --------LISQDIGYTIfstfgAFYIPLLLMLILYWKIYRA------AARERKAAKTLGIILGAFIVcwlpFFLVALIV 216

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 384551642 258 YLRFSATYTPFWDNtIALTFSVFAPLFNPIIYSLRNKDMKDA 299
Cdd:cd15064  217 PLCSHCWIPLALKS-FFLWLGYFNSLINPLIYTFFNKDFRKA 257

7tmA_5-HT1A_vertebrates

cd15330

serotonin receptor subtype 1A from vertebrates, member of the class A family of ...

39-299

3.78e-06

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320453 [Multi-domain] Cd Length: 260 Bit Score: 47.28 E-value: 3.78e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  39 VTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFHSLGNTEGTLLTVM 118
Cdd:cd15330   15 IFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAI 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 119 AIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIV-WISTLPFCGPNqitqifcdftpllklACTdasviLV 197
Cdd:cd15330   95 ALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISIPPMLgWRTPEDRSDPD---------------ACT-----IS 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 198 QDviHALAILITSLIISLSYIRIIVVILSISSTEGR-KKAFSTCAAHIAVFLL----FFGSVALMYLRFSATYTPFWDNT 272
Cdd:cd15330  155 KD--PGYTIYSTFGAFYIPLILMLVLYGRIFKAAAReRKTVKTLGIIMGTFILcwlpFFIVALVLPFCESTCHMPELLGA 232

                        250       260
                 ....*....|....*....|....*..
gi 384551642 273 IALTFSVFAPLFNPIIYSLRNKDMKDA 299
Cdd:cd15330  233 IINWLGYSNSLLNPIIYAYFNKDFQSA 259

7tmA_Dop1R2-like

cd15067

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...

31-162

1.60e-05

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.

Pssm-ID: 320195 [Multi-domain] Cd Length: 262 Bit Score: 45.42 E-value: 1.60e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  31 LLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFHSLGNT 110
Cdd:cd15067    6 LSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSILHEMTGGYWLFGRDWCDVWHSFDVLAST 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 384551642 111 EGTL-LTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVW 162
Cdd:cd15067   86 ASILnLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSALISFPAIAW 138

7tmA_GPR84-like

cd15210

G protein-coupled receptor 84 and similar proteins, member of the class A family of ...

39-158

5.88e-05

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.

Pssm-ID: 320338 [Multi-domain] Cd Length: 254 Bit Score: 43.79 E-value: 5.88e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  39 VTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFHSLGNTEGTLLTVM 118
Cdd:cd15210   15 VPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAASTFLHQAWIHGETLCRVFPLLRYGLVAVSLLTLVLI 94

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 384551642 119 AIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLP 158
Cdd:cd15210   95 TLNRYILIAHPSLYPRIYTRRGLALMIAGTWIFSFGSFLP 134

7tmA_Trissin_R

cd15012

trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...

29-300

2.86e-04

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320140 [Multi-domain] Cd Length: 277 Bit Score: 41.66 E-value: 2.86e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  29 FPLLFIYIFIVT--GNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFHS 106
Cdd:cd15012    2 FIILYTLVFCCCffGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHSL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 107 LGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQifcdfTPLLK 186
Cdd:cd15012   82 SYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFVFSQTVEILVTQDGQE-----EEICV 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 187 LACTDASVILVQDVIHALAILITSLIISLSYIRIIVVILSISSTEGRKKAFSTCAAHIAVFLLFF--GSVALMYLRFSAT 264
Cdd:cd15012  157 LDREMFNSKLYDTINFIVWYLIPLLIMTVLYSKISIVLWKSSSIEARRKVVRLLVAVVVSFALCNlpYHARKMWQYWSEP 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 384551642 265 YTPFWDNTIALTFSVFAPLF-----NPIIYSLRNKDMKDAI 300
Cdd:cd15012  237 YRCDSNWNALLTPLTFLVLYfnsavNPLLYAFLSKRFRQSM 277

7tmA_Beta_AR

cd15058

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...

29-144

3.43e-04

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320186 [Multi-domain] Cd Length: 305 Bit Score: 41.67 E-value: 3.43e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  29 FPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLqmyfFHSLG 108
Cdd:cd15058    5 LLLALIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCEL----WTSVD 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 384551642 109 NTEGT----LLTVMAIDRYVAICNPLRYPNIMTpRLCAQL 144
Cdd:cd15058   81 VLCVTasieTLCVIAVDRYIAITRPLRYQVLLT-KRRARV 119

7tmA_Adenosine_R_A1

cd15071

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...

34-162

4.43e-04

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.

Pssm-ID: 341323 [Multi-domain] Cd Length: 290 Bit Score: 41.37 E-value: 4.43e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  34 IYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPkmLSNLISEQKTISFIGCLLQMYFFHSLGNTEGT 113
Cdd:cd15071   10 IALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP--LAIIINIGPQTEFYSCLMVACPVLILTQSSIL 87

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 384551642 114 LLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLI-LLPEIVW 162
Cdd:cd15071   88 ALLAIAVDRYLRVKIPTRYKSVVTPRRAAVAIAGCWILSFLVgLTPMFGW 137

7tmA_KiSS1R

cd15095

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...

115-291

4.90e-04

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.

Pssm-ID: 320223 [Multi-domain] Cd Length: 288 Bit Score: 41.11 E-value: 4.90e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 115 LTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLP--------EIVWISTLPFC---GPNQ--------IT 175
Cdd:cd15095   91 LTALSVDRYYAIVHPIRSLRFRTPRVAVVVSACIWIVSFLLSIPvaiyyrleEGYWYGPQTYCrevWPSKafqkaymiYT 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 176 QIFCDFTPLL-----------KLACTDASVILVQDVIHALAILITSLIislSYIRIIVVILsisstegrkkaFSTCAAHI 244
Cdd:cd15095  171 VLLTYVIPLAiiavcyglilrRLWRRSVDGNNQSEQLSERALRQKRKV---TRMVIVVVVL-----------FAICWLPN 236

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 384551642 245 AVFLLFFgsvaLMYLRFSATYTPFWDNTIALTFSVFAPLFNPIIYSL 291
Cdd:cd15095  237 HVLNLWQ----RFDPNFPETYATYALKIAALCLSYANSAVNPFVYAF 279

7tmA_Melanopsin-like

cd15083

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...

31-224

5.41e-04

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320211 [Multi-domain] Cd Length: 291 Bit Score: 41.16 E-value: 5.41e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  31 LLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCllQMYFF--HSLG 108
Cdd:cd15083    7 ILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGC--DMYGFsgGLFG 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 109 NTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIV-WISTLPfcgpnQITQIFCDFTPLLKL 187
Cdd:cd15083   85 IMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLPPLFgWSRYVL-----EGLLTSCSFDYLSRD 159

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 384551642 188 ACTDASVILVQDVIHALAIlitsLIISLSYIRIIVVI 224
Cdd:cd15083  160 DANRSYVICLLIFGFVLPL----LIIIYCYSFIFRAV 192

7tmA_purinoceptor-like

cd14982

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...

94-289

6.51e-04

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341318 [Multi-domain] Cd Length: 283 Bit Score: 40.71 E-value: 6.51e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  94 FIGCLLQMYFFHSLGntegtLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIvwISTLPFCGPNQ 173
Cdd:cd14982   75 LTGLLFYINMYGSIL-----FLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVPLL--LLRSTIAKENN 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 174 ITQIFCDFTPLLKLACTDASVILVqdvihaLAILITSLIISLSYIRIIVVILSISSTEG----RKKAFSTCAAHIAVFLL 249
Cdd:cd14982  148 STTCFEFLSEWLASAAPIVLIALV------VGFLIPLLIILVCYSLIIRALRRRSKQSQksvrKRKALRMILIVLAVFLV 221

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 384551642 250 FFGSVALMYLRFSATYTPFWDNT-----------IALTFSVFAPLFNPIIY 289
Cdd:cd14982  222 CFLPYHVTRILYLLVRLSFIADCsarnslykayrITLCLASLNSCLDPLIY 272

7tmA_Opioid_R-like

cd14970

opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...

115-168

7.68e-04

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.

Pssm-ID: 320101 [Multi-domain] Cd Length: 282 Bit Score: 40.36 E-value: 7.68e-04

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 384551642 115 LTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPF 168
Cdd:cd14970   90 LTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPVIIFARTLQE 143

7tmA_AstC_insect

cd15094

somatostatin-like receptor for allatostatin C, member of the class A family of ...

110-175

9.20e-04

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.

Pssm-ID: 320222 [Multi-domain] Cd Length: 282 Bit Score: 40.15 E-value: 9.20e-04

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 384551642 110 TEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQIT 175
Cdd:cd15094   85 TSSFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVMLPIILYASTVPDSGRYSCT 150

7tmA_Histamine_H1R

cd15050

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...

31-162

1.01e-03

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320178 [Multi-domain] Cd Length: 263 Bit Score: 40.10 E-value: 1.01e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  31 LLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFHSLGNT 110
Cdd:cd15050    7 LSTISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMDYVASTA 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 384551642 111 EGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVW 162
Cdd:cd15050   87 SIFSLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLSFLWVIPILGW 138

7tmA_TAARs

cd15055

trace amine-associated receptors, member of the class A family of seven-transmembrane G ...

119-139

1.14e-03

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320183 [Multi-domain] Cd Length: 285 Bit Score: 39.84 E-value: 1.14e-03

                         10        20
                 ....*....|....*....|.
gi 384551642 119 AIDRYVAICNPLRYPNIMTPR 139
Cdd:cd15055   95 AIDRYVAVCDPLLYPTKITIR 115

7tmA_CCKR-like

cd14993

cholecystokinin receptors and related proteins, member of the class A family of ...

115-294

1.39e-03

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.

Pssm-ID: 320124 [Multi-domain] Cd Length: 296 Bit Score: 39.89 E-value: 1.39e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 115 LTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNqitqifcdFTPLLKLACTDASV 194
Cdd:cd14993   91 LVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIMLPLLVVYELEEIISSE--------PGTITIYICTEDWP 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 195 ILVQDVIHALAILITS-----LIISLSYIRIIVVILSISSTEGRKKAFSTCAAH------------IAVFLLFFGS---- 253
Cdd:cd14993  163 SPELRKAYNVALFVVLyvlplLIISVAYSLIGRRLWRRKPPGDRGSANSTSSRRilrskkkvarmlIVVVVLFALSwlpy 242

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 384551642 254 -VALMYLRFSATYTPFWDNTIALTFSVFAPL------FNPIIYSLRNK 294
Cdd:cd14993  243 yVLSILLDFGPLSSEESDENFLLILPFAQLLgysnsaINPIIYCFMSK 290

7tmA_CCK-BR

cd15979

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...

34-172

1.47e-03

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320645 [Multi-domain] Cd Length: 275 Bit Score: 39.80 E-value: 1.47e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  34 IYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFHSLGNTEGT 113
Cdd:cd15979   10 IFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVICKAVAYLMGVSVSVSTF 89

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 384551642 114 LLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPN 172
Cdd:cd15979   90 SLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIPYPVYSVTVPVPVGD 148

7tmA_SSTR

cd15093

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...

115-167

2.07e-03

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.

Pssm-ID: 320221 [Multi-domain] Cd Length: 280 Bit Score: 38.98 E-value: 2.07e-03

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 384551642 115 LTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLP 167
Cdd:cd15093   90 LTVMSVDRYLAVVHPIKSARWRRPRVAKVVNLAVWVASLLVILPVVVFAGTRE 142

7tmA_GPR119_R_insulinotropic_receptor

cd15104

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...

97-299

2.94e-03

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320232 [Multi-domain] Cd Length: 283 Bit Score: 38.89 E-value: 2.94e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  97 CLLQMYFFHSLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLI-----LLPEIVWISTLPFCG- 170
Cdd:cd15104   73 CLLRMCFVITSCAASVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGLIgflplISPQFQQTSYKGKCSf 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 171 ------PNQITQIFCDFTPLLKLACTDASVILVQDVIHALAILITSLIISLSYIRiivvilsiSSTEGRKKAFSTCAAHI 244
Cdd:cd15104  153 faafhpRVLLVLSCMVFFPALLLFVFCYCDILKIARVHSRAIYKVEHALARQIHP--------RRTLSDFKAARTVAVLI 224

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 384551642 245 AVFLLFFGS--VALMYLRFSATYTPF-WDNTIALTFSVFAPLFNPIIYSLRNKDMKDA 299
Cdd:cd15104  225 GCFLLSWLPfqITGLVQALCDECKLYdVLEDYLWLLGLCNSLLNPWIYAFWQKEVRRA 282

7tmA_Vasopressin_Oxytocin

cd15196

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...

31-161

2.99e-03

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320324 [Multi-domain] Cd Length: 264 Bit Score: 38.75 E-value: 2.99e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  31 LLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFIS-------IFSFLEMwyttatIPKMLSNLiseqkTISFIG----CLL 99
Cdd:cd15196    7 LATILVLALFGNSCVLLVLYRRRRKLSRMHLFILhlsvadlLVALFNV------LPQLIWDI-----TYRFYGgdllCRL 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 384551642 100 qMYFFHSLGNTEGT-LLTVMAIDRYVAICNPLRYPNImTPRLCAQLTAGSCVFGFLILLPEIV 161
Cdd:cd15196   76 -VKYLQVVGMYASSyVLVATAIDRYIAICHPLSSHRW-TSRRVHLMVAIAWVLSLLLSIPQLF 136

7tmA_TAAR2_3_4

cd15312

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...

115-291

3.17e-03

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320437 [Multi-domain] Cd Length: 289 Bit Score: 38.49 E-value: 3.17e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 115 LTVMAIDRYVAICNPLRYPNIMTPRLCAQLTA----GSCVFGFLILLPEIVWISTLPFcgpnqitqifcdftpLLKLACT 190
Cdd:cd15312   91 LCFIAVDRYYAVCDPLHYRTKITTPVIKVFLViswsVPCLFAFGVVFSEVNLEGIEDY---------------VALVSCT 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 191 DASVILVQDVIHALAILITSLIISLSYIRIIVVILSISSTEGR----------------------KKAFSTCAAHIAVFL 248
Cdd:cd15312  156 GSCVLIFNKLWGVIASLIAFFIPGTVMIGIYIKIFFVARKHAKvinnrpsvtkgdsknklskkkeRKAAKTLSIVMGVFL 235

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 384551642 249 L-----FFGSVALMYLRFSatyTPFWDNTIALTFSVFAPLFNPIIYSL 291
Cdd:cd15312  236 LcwlpfFVATLIDPFLNFS---TPVDLFDALVWLGYFNSTCNPLIYGF 280

7tmA_GPRnna14-like

cd15001

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...

30-300

3.41e-03

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320132 [Multi-domain] Cd Length: 266 Bit Score: 38.41 E-value: 3.41e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  30 PLLFIY--IFIV--TGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCllqmYFFH 105
Cdd:cd15001    1 PVIIVYviTFVLglIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLC----KAVA 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 106 SLGNTEGTL----LTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQIFCdf 181
Cdd:cd15001   77 YLQLLSFICsvltLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILASPVLFGQGLVRYESENGVTVYHC-- 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 182 tpllKLACTDASVILVQDVIHALAI-LITSLIISLSYIRiivvilsisstEGRKKAFSTCAAHIAVFLLFFGSVALMYLR 260
Cdd:cd15001  155 ----QKAWPSTLYSRLYVVYLAIVIfFIPLIVMTFAYAR-----------DTRKQVIKMLISVVVLFAVCWGPLLIDNLL 219

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 384551642 261 FSATYTPFWDNT----IALTFSVFAPL---FNPIIYSLRNKDMKDAI 300
Cdd:cd15001  220 VSFDVISTLHTQalkyMRIAFHLLSYAnscINPIIYAFMSKNFRSSF 266

7tmA_NPYR-like

cd15203

neuropeptide Y receptors and related proteins, member of the class A family of ...

115-224

3.88e-03

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.

Pssm-ID: 320331 [Multi-domain] Cd Length: 293 Bit Score: 38.35 E-value: 3.88e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 115 LTVMAIDRYVAICNPLRypNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLPFCGPNQITQI-FC-DFTPL--LKLACT 190
Cdd:cd15203   91 LTAIAIDRYQLIVYPTR--PRMSKRHALLIIALIWILSLLLSLPLAIFQELSDVPIEILPYCGyFCtESWPSssSRLIYT 168

                         90       100       110
                 ....*....|....*....|....*....|....
gi 384551642 191 dASVILVQDVIHAlailitsLIISLSYIRIIVVI 224
Cdd:cd15203  169 -ISVLVLQFVIPL-------LIISFCYFRISLKL 194

7tmA_GPR101

cd15215

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...

115-154

5.08e-03

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320343 [Multi-domain] Cd Length: 261 Bit Score: 37.90 E-value: 5.08e-03

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 384551642 115 LTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFL 154
Cdd:cd15215   90 IVVVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWIVSVL 129

7tmA_D1-like_dopamine_R

cd15057

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...

115-299

5.48e-03

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320185 [Multi-domain] Cd Length: 299 Bit Score: 37.79 E-value: 5.48e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 115 LTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLI-LLP-EIVW--ISTLPFCGPNQITQIFCDFTpLLKLACT 190
Cdd:cd15057   91 LCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSALIsFIPvQLGWhrADDTSEALALYADPCQCDSS-LNRTYAI 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642 191 DASVIlvqdvihalAILITSLIISLSYIRIIVV----ILSISSTEGR------------------KKAFSTCAAHIAVFL 248
Cdd:cd15057  170 SSSLI---------SFYIPVAIMIVTYTRIYRIarrqIRRIAALERAaqestnpdsslrsslrreTKALKTLSIIMGVFV 240

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 384551642 249 L-----FFGSVALMYLRFSATYTPFWDNTialTFSVFAPL------FNPIIYSLrNKDMKDA 299
Cdd:cd15057  241 CcwlpfFILNCVLPFCDLRTAQFPCVPDT---TFIVFVWLgwanssLNPIIYAF-NADFRKA 298

7tmA_Beta3_AR

cd15959

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...

31-145

5.91e-03

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.

Pssm-ID: 320625 [Multi-domain] Cd Length: 302 Bit Score: 37.96 E-value: 5.91e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  31 LLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPKMLSNLISEQKTISFIGCLLQMYFFHSLGNT 110
Cdd:cd15959    7 LSLAILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVDVLCVTA 86

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 384551642 111 EGTLLTVMAIDRYVAICNPLRYPNIMTPRlCAQLT 145
Cdd:cd15959   87 SIETLCAIAVDRYLAITNPLRYEALVTKR-RARTA 120

7tmA_SSTR1

cd15970

somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...

115-167

6.03e-03

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.

Pssm-ID: 320636 [Multi-domain] Cd Length: 276 Bit Score: 37.58 E-value: 6.03e-03

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 384551642 115 LTVMAIDRYVAICNPLRYPNIMTPRLCAQLTAGSCVFGFLILLPEIVWISTLP 167
Cdd:cd15970   90 LTVLSIDRYIAVVHPIKAARYRRPTVAKMVNLGVWVFSILVILPIIIFSNTAP 142

7tmA_TAAR5-like

cd15317

trace amine-associated receptor 5 and similar receptors, member of the class A family of ...

25-154

6.22e-03

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320440 [Multi-domain] Cd Length: 290 Bit Score: 37.81 E-value: 6.22e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384551642  25 LLYFFPLLFIYIFIVTGNLMIFFAVRLDTRLHNPMYNFISIFSFLEMWYTTATIPkmlSNLISEQKTISFIG---CLLQM 101
Cdd:cd15317    1 VIIYIVLVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMP---FSMIRTVETCWYFGdlfCKFHT 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 384551642 102 YFFHSLGNTEGTLLTVMAIDRYVAICNPLRYPNIMTPR------LCAQLTAGSCVFGFL 154
Cdd:cd15317   78 GLDLLLCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQvawrfiAIGWLVPGIYTFGLI 136

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01