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Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24908, updated on 17-Aug-2024

Summary

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Official Symbol
Dnajb9provided by RGD
Official Full Name
DnaJ heat shock protein family (Hsp40) member B9provided by RGD
Primary source
RGD:3070
See related
EnsemblRapid:ENSRNOG00000004006 AllianceGenome:RGD:3070
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mdg1; ERdj4
Summary
Predicted to enable Hsp70 protein binding activity; chaperone binding activity; and misfolded protein binding activity. Predicted to be involved in several processes, including negative regulation of IRE1-mediated unfolded protein response; positive regulation of immunoglobulin production; and ubiquitin-dependent ERAD pathway. Located in cytoplasm and nucleolus. Orthologous to human DNAJB9 (DnaJ heat shock protein family (Hsp40) member B9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 279.8), Heart (RPKM 260.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dnajb9 in Genome Data Viewer
Location:
6q21
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (66997842..67007371, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (61270385..61276795, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (64165913..64170122, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479371 Neighboring gene uncharacterized LOC134479372 Neighboring gene uncharacterized LOC120103526 Neighboring gene DnaJ heat shock protein family (Hsp40) member B6, pseudogene 4 Neighboring gene patatin-like phospholipase domain containing 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The BiP cochaperone ERdj4 is required for B cell development and function. Fritz JM, et al. PLoS One, 2014. PMID 25222125, Free PMC Article
  2. High levels of the molecular chaperone Mdg1/ERdj4 reflect the activation state of endothelial cells. Berger BJ, et al. Exp Cell Res, 2003 Oct 15. PMID 14516790
  3. Upregulation of the cochaperone Mdg1 in endothelial cells is induced by stress and during in vitro angiogenesis. Pröls F, et al. Exp Cell Res, 2001 Sep 10. PMID 11525638
  4. ERdj4 protein is a soluble endoplasmic reticulum (ER) DnaJ family protein that interacts with ER-associated degradation machinery. Lai CW, et al. J Biol Chem, 2012 Mar 9. PMID 22267725, Free PMC Article
  5. Identification and characterization of a novel endoplasmic reticulum (ER) DnaJ homologue, which stimulates ATPase activity of BiP in vitro and is induced by ER stress. Shen Y, et al. J Biol Chem, 2002 May 3. PMID 11836248

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables Hsp70 protein binding ISO
Inferred from Sequence Orthology
more info
  
enables misfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables misfolded protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-folding chaperone binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in B cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in B cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in ERAD pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of IRE1-mediated unfolded protein response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of immunoglobulin production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of immunoglobulin production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
  
involved_in response to endoplasmic reticulum stress ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to unfolded protein IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum lumen ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum lumen ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
dnaJ homolog subfamily B member 9
Names
DnaJ (Hsp40) homolog, subfamily B, member 9
ER-resident protein ERdj4
dnaJ homolog, subfamily b, member 9
endoplasmic reticulum DNA J domain-containing protein 4
mdg-1
microvascular endothelial differentiation gene 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012699.3 → NP_036831.2  dnaJ homolog subfamily B member 9 precursor

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/Swiss-Prot
    P97554
    UniProtKB/TrEMBL
    A6HBE3
    Related
    ENSRNOP00000005363.3, ENSRNOT00000005363.7
    Conserved Domains (1) summary
    COG0484
    Location:23 → 135
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    66997842..67007371 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039111791.2 → XP_038967719.1  dnaJ homolog subfamily B member 9 isoform X1

    Related
    ENSRNOP00000099445.1, ENSRNOT00000160259.1
    Conserved Domains (1) summary
    COG0484
    Location:35 → 147
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97554.2 GenPept UniProtKB/Swiss-Prot:P97554

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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