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Slc4a3 solute carrier family 4 member 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24781, updated on 2-Nov-2024

Summary

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Official Symbol
Slc4a3provided by RGD
Official Full Name
solute carrier family 4 member 3provided by RGD
Primary source
RGD:3712
See related
EnsemblRapid:ENSRNOG00000020138 AllianceGenome:RGD:3712
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ae3; Aep3
Summary
Enables chloride:bicarbonate antiporter activity and enzyme binding activity. Predicted to be involved in several processes, including bicarbonate transport; regulation of cardiac muscle cell action potential; and regulation of pH. Predicted to act upstream of or within cardiac conduction. Located in plasma membrane. Orthologous to human SLC4A3 (solute carrier family 4 member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 210.4), Brain (RPKM 75.5) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Slc4a3 in Genome Data Viewer
Location:
9q33
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (84484749..84497746)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (77036243..77053940)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (82742207..82755119)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene inhibin subunit alpha Neighboring gene serine/threonine kinase 11 interacting protein Neighboring gene uncharacterized LOC120094715 Neighboring gene uncharacterized LOC134480388

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Sasanquasaponin up-regulates anion exchanger 3 expression and elicits cardioprotection via NO/RAS/ERK1/2 pathway. Chen HP, et al. Can J Physiol Pharmacol, 2012 Jul. PMID 22693949
  2. Anion exchanger 3 is required for sasanquasaponin to inhibit ischemia/reperfusion-induced elevation of intracellular Cl- concentration and to elicit cardioprotection. Chen HP, et al. J Cell Biochem, 2011 Oct. PMID 21608017
  3. Transport activity of AE3 chloride/bicarbonate anion-exchange proteins and their regulation by intracellular pH. Sterling D, et al. Biochem J, 1999 Nov 15. PMID 10548554, Free PMC Article
  4. Loss-of-activity-mutation in the cardiac chloride-bicarbonate exchanger AE3 causes short QT syndrome. Thorsen K, et al. Nat Commun, 2017 Nov 22. PMID 29167417, Free PMC Article
  5. Chromosomal mapping of the rat Slc4a family of anion exchanger genes, Ae1, Ae2, and Ae3. Simon JS, et al. Mamm Genome, 1996 May. PMID 8661729

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The increase in AE(3) expression occurring during SQS pretreatment was almost completely abolished.
    Title: Sasanquasaponin up-regulates anion exchanger 3 expression and elicits cardioprotection via NO/RAS/ERK1/2 pathway.
  2. AE(3) is required for SQS to inhibit sI/R-induced elevation of [Cl(-)](i), which subsequently inhibited sI/R-induced Ca(2+) overload, ROS production, and cell apoptosis.
    Title: Anion exchanger 3 is required for sasanquasaponin to inhibit ischemia/reperfusion-induced elevation of intracellular Cl- concentration and to elicit cardioprotection.
  3. Coexpression of carbonic anhydrase IX and SLC4A3 activated SLC4A3 mediated transport.
    Title: Interactions of transmembrane carbonic anhydrase, CAIX, with bicarbonate transporters.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables bicarbonate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables chloride:bicarbonate antiporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables chloride:bicarbonate antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables chloride:bicarbonate antiporter activity ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in bicarbonate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in bicarbonate transport IEA
Inferred from Electronic Annotation
more info
  
involved_in bicarbonate transport ISO
Inferred from Sequence Orthology
more info
  
involved_in cardiac conduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cardiac conduction ISO
Inferred from Sequence Orthology
more info
  
involved_in chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in pH reduction IEA
Inferred from Electronic Annotation
more info
  
involved_in pH reduction ISO
Inferred from Sequence Orthology
more info
  
involved_in pH reduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cardiac muscle cell action potential IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cardiac muscle cell action potential ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cardiac muscle cell action potential ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of intracellular pH IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of intracellular pH IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of intracellular pH ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
anion exchange protein 3
Names
AE 3
B3RP-3
Solute carrier family 4, member 3, anion exchange protein 3
anion exchanger 3
band 3-related protein 3
neuronal band 3-like protein
solute carrier family 4 (anion exchanger), member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017049.2 → NP_058745.2  anion exchange protein 3

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    P23348
    UniProtKB/TrEMBL
    A6JW47, G3V8P8
    Conserved Domains (1) summary
    TIGR00834
    Location:321 → 1226
    ae; anion exchange protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    84484749..84497746
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017596279.3 → XP_017451768.1  anion exchange protein 3 isoform X1

    UniProtKB/Swiss-Prot
    P23348
    UniProtKB/TrEMBL
    A6JW47, G3V8P8
    Conserved Domains (1) summary
    TIGR00834
    Location:321 → 1226
    ae; anion exchange protein

  2. XM_017596280.3 → XP_017451769.1  anion exchange protein 3 isoform X1

    UniProtKB/Swiss-Prot
    P23348
    UniProtKB/TrEMBL
    A6JW47, G3V8P8
    Conserved Domains (1) summary
    TIGR00834
    Location:321 → 1226
    ae; anion exchange protein

  3. XM_017596277.3 → XP_017451766.1  anion exchange protein 3 isoform X1

    UniProtKB/Swiss-Prot
    P23348
    UniProtKB/TrEMBL
    A6JW47, G3V8P8
    Related
    ENSRNOP00000027337.1, ENSRNOT00000027337.5
    Conserved Domains (1) summary
    TIGR00834
    Location:321 → 1226
    ae; anion exchange protein

  4. XM_017596276.3 → XP_017451765.1  anion exchange protein 3 isoform X1

    UniProtKB/Swiss-Prot
    P23348
    UniProtKB/TrEMBL
    A6JW47, G3V8P8
    Conserved Domains (1) summary
    TIGR00834
    Location:321 → 1226
    ae; anion exchange protein

  5. XM_063266648.1 → XP_063122718.1  anion exchange protein 3 isoform X1

    UniProtKB/TrEMBL
    A6JW47, G3V8P8

  6. XM_063266649.1 → XP_063122719.1  anion exchange protein 3 isoform X4

  7. XM_039083028.2 → XP_038938956.1  anion exchange protein 3 isoform X2

    UniProtKB/Swiss-Prot
    P23348
    Conserved Domains (1) summary
    TIGR00834
    Location:251 → 1156
    ae; anion exchange protein

  8. XM_063266650.1 → XP_063122720.1  anion exchange protein 3 isoform X4

  9. XM_006245149.5 → XP_006245211.1  anion exchange protein 3 isoform X3

    Conserved Domains (3) summary
    TIGR00834
    Location:124 → 1029
    ae; anion exchange protein
    pfam00955
    Location:477 → 959
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:159 → 421
    Band_3_cyto; Band 3 cytoplasmic domain

  10. XM_063266651.1 → XP_063122721.1  anion exchange protein 3 isoform X5

  11. XM_039083030.2 → XP_038938958.1  anion exchange protein 3 isoform X6

    Conserved Domains (1) summary
    cl26877
    Location:1 → 736
    Band_3_cyto; Band 3 cytoplasmic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23348.1 GenPept UniProtKB/Swiss-Prot:P23348

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