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DOP1A DOP1 leucine zipper like protein A [ Homo sapiens (human) ]

Gene ID: 23033, updated on 3-Apr-2024

Summary

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Official Symbol
DOP1Aprovided by HGNC
Official Full Name
DOP1 leucine zipper like protein Aprovided by HGNC
Primary source
HGNC:HGNC:21194
See related
Ensembl:ENSG00000083097 MIM:616823; AllianceGenome:HGNC:21194
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DOP1; DOPEY1; KIAA1117; dJ202D23.2
Summary
Predicted to be involved in Golgi to endosome transport and endoplasmic reticulum organization. Predicted to be located in Golgi membrane. Predicted to be active in endosome and trans-Golgi network. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 7.6), thyroid (RPKM 6.7) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See DOP1A in Genome Data Viewer
Location:
6q14.1
Exon count:
46
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (83067671..83171350)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (84290676..84394587)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (83777390..83881069)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377877 Neighboring gene MPRA-validated peak5926 silencer Neighboring gene ubiquitin protein ligase E3D Neighboring gene leucine aminopeptidase 3 pseudogene 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:83710771-83710962 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:83747652-83748851 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24780 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24781 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17355 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24782 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24783 Neighboring gene NANOG hESC enhancer GRCh37_chr6:83821047-83821571 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17356 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:83902947-83903446 Neighboring gene phosphoglucomutase 3 Neighboring gene RWD domain containing 2A Neighboring gene MPRA-validated peak5928 silencer Neighboring gene malic enzyme 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:84004031-84004257 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24784 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17358

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Diagnostic significance of alternative splice variants of REST and DOPEY1 in the peripheral blood of patients with breast cancer. Lend AK, et al. Tumour Biol, 2015 Apr. PMID 25424701
  2. Morphogenesis in Aspergillus nidulans requires Dopey (DopA), a member of a novel family of leucine zipper-like proteins conserved from yeast to humans. Pascon RC, et al. Mol Microbiol, 2000 Jun. PMID 10931277
  3. Mon2, a relative of large Arf exchange factors, recruits Dop1 to the Golgi apparatus. Gillingham AK, et al. J Biol Chem, 2006 Jan 27. PMID 16301316
  4. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Kikuno R, et al. DNA Res, 1999 Jun 30. PMID 10470851
  5. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. Yao Z, et al. Mol Cell, 2017 Jan 19. PMID 28065597, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ35610

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in Golgi to endosome transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi-associated vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein dopey-1
Names
dopey family member 1
homolog of yeast DOP1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199942.2 → NP_001186871.1  protein dopey-1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region and has an alternate in-frame exon in the 3' coding region compared to variant 1. The resulting protein (isoform b) is longer compared to isoform a.
    Source sequence(s)
    AL121716, AL139333
    Consensus CDS
    CCDS64467.1
    UniProtKB/TrEMBL
    B2RWN9, F6U2K4, Q5TA12
    Related
    ENSP00000237163.6, ENST00000237163.9
    Conserved Domains (2) summary
    pfam04118
    Location:13 → 295
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:2082 → 2318
    Dopey_N; Dopey, N-terminal

  2. NM_001385856.1 → NP_001372785.1  protein dopey-1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL121716, AL139333
    UniProtKB/TrEMBL
    B2RWN9
    Conserved Domains (2) summary
    pfam04118
    Location:13 → 297
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:2081 → 2317
    Dopey_N; Dopey, N-terminal

  3. NM_001385857.1 → NP_001372786.1  protein dopey-1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL121716, AL139333
    UniProtKB/TrEMBL
    B2RWN9
    Conserved Domains (2) summary
    pfam04118
    Location:13 → 297
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:2081 → 2317
    Dopey_N; Dopey, N-terminal

  4. NM_001385858.1 → NP_001372787.1  protein dopey-1 isoform e

    Status: VALIDATED

    Source sequence(s)
    AL121716, AL139333
    UniProtKB/TrEMBL
    B2RWN9
    Conserved Domains (1) summary
    cl04407
    Location:1 → 146
    Dopey_N; Dopey, N-terminal

  5. NM_001385859.1 → NP_001372788.1  protein dopey-1 isoform f

    Status: VALIDATED

    Source sequence(s)
    AL121716, AL139333
    UniProtKB/TrEMBL
    B2RWN9
    Conserved Domains (1) summary
    cl04407
    Location:1816 → 1976
    Dopey_N; Dopey, N-terminal

  6. NM_001385860.1 → NP_001372789.1  protein dopey-1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL121716, AL139333
    UniProtKB/TrEMBL
    B2RWN9
    Conserved Domains (2) summary
    pfam04118
    Location:13 → 297
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:2081 → 2317
    Dopey_N; Dopey, N-terminal

  7. NM_001385861.1 → NP_001372790.1  protein dopey-1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL121716, AL139333
    UniProtKB/TrEMBL
    B2RWN9
    Conserved Domains (2) summary
    pfam04118
    Location:13 → 297
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:2081 → 2317
    Dopey_N; Dopey, N-terminal

  8. NM_001385863.1 → NP_001372792.1  protein dopey-1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL121716, AL139333
    Consensus CDS
    CCDS64467.1
    UniProtKB/TrEMBL
    B2RWN9, F6U2K4, Q5TA12
    Conserved Domains (2) summary
    pfam04118
    Location:13 → 295
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:2082 → 2318
    Dopey_N; Dopey, N-terminal

  9. NM_001385864.1 → NP_001372793.1  protein dopey-1 isoform g

    Status: VALIDATED

    Source sequence(s)
    AL121716, AL139333
    Conserved Domains (1) summary
    cl04407
    Location:1579 → 1815
    Dopey_N; Dopey, N-terminal

  10. NM_001385865.1 → NP_001372794.1  protein dopey-1 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL121716, AL139333
    UniProtKB/TrEMBL
    B2RWN9
    Conserved Domains (2) summary
    pfam04118
    Location:13 → 295
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:2082 → 2318
    Dopey_N; Dopey, N-terminal

  11. NM_015018.4 → NP_055833.2  protein dopey-1 isoform a

    See identical proteins and their annotated locations for NP_055833.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter protein (isoform a).
    Source sequence(s)
    AL121716, AL139333
    Consensus CDS
    CCDS4996.1
    UniProtKB/Swiss-Prot
    Q5JWR5, Q86XV1, Q9H5J5, Q9NSL4, Q9UPN5, Q9Y414
    UniProtKB/TrEMBL
    B2RWN9
    Related
    ENSP00000195654.3, ENST00000349129.7
    Conserved Domains (2) summary
    pfam04118
    Location:13 → 299
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:2091 → 2327
    Dopey_N; Dopey, N-terminal

RNA

  1. NR_169790.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL121716, AL139333

  2. NR_169791.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL121716, AL139333

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    83067671..83171350
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010559.2 → XP_016866048.1  protein dopey-1 isoform X1

    UniProtKB/TrEMBL
    B2RWN9

  2. XM_017010564.2 → XP_016866053.1  protein dopey-1 isoform X5

    UniProtKB/Swiss-Prot
    Q5JWR5, Q86XV1, Q9H5J5, Q9NSL4, Q9UPN5, Q9Y414
    UniProtKB/TrEMBL
    B2RWN9
    Conserved Domains (2) summary
    pfam04118
    Location:13 → 299
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:2091 → 2327
    Dopey_N; Dopey, N-terminal

  3. XM_017010572.2 → XP_016866061.1  protein dopey-1 isoform X11

    UniProtKB/TrEMBL
    B2RWN9

  4. XM_047418447.1 → XP_047274403.1  protein dopey-1 isoform X15

  5. XM_047418448.1 → XP_047274404.1  protein dopey-1 isoform X15

  6. XM_017010571.2 → XP_016866060.1  protein dopey-1 isoform X9

    UniProtKB/TrEMBL
    B2RWN9

  7. XM_047418442.1 → XP_047274398.1  protein dopey-1 isoform X12

  8. XM_047418443.1 → XP_047274399.1  protein dopey-1 isoform X12

  9. XM_047418451.1 → XP_047274407.1  protein dopey-1 isoform X18

  10. XM_011535619.3 → XP_011533921.1  protein dopey-1 isoform X3

    See identical proteins and their annotated locations for XP_011533921.1

    UniProtKB/TrEMBL
    B2RWN9
    Conserved Domains (2) summary
    pfam04118
    Location:13 → 299
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:2081 → 2317
    Dopey_N; Dopey, N-terminal

  11. XM_047418434.1 → XP_047274390.1  protein dopey-1 isoform X7

  12. XM_017010561.2 → XP_016866050.1  protein dopey-1 isoform X2

    UniProtKB/TrEMBL
    B2RWN9, F6U2K4, Q5TA12
    Conserved Domains (2) summary
    pfam04118
    Location:13 → 295
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:2082 → 2318
    Dopey_N; Dopey, N-terminal

  13. XM_017010570.2 → XP_016866059.1  protein dopey-1 isoform X8

    UniProtKB/TrEMBL
    B2RWN9

  14. XM_047418440.1 → XP_047274396.1  protein dopey-1 isoform X10

  15. XM_047418445.1 → XP_047274401.1  protein dopey-1 isoform X13

  16. XM_047418450.1 → XP_047274406.1  protein dopey-1 isoform X17

  17. XM_017010560.3 → XP_016866049.1  protein dopey-1 isoform X1

    UniProtKB/TrEMBL
    B2RWN9

  18. XM_047418430.1 → XP_047274386.1  protein dopey-1 isoform X3

  19. XM_047418435.1 → XP_047274391.1  protein dopey-1 isoform X7

  20. XM_047418449.1 → XP_047274405.1  protein dopey-1 isoform X16

  21. XM_047418446.1 → XP_047274402.1  protein dopey-1 isoform X14

  22. XM_017010562.3 → XP_016866051.1  protein dopey-1 isoform X2

    UniProtKB/TrEMBL
    B2RWN9, F6U2K4, Q5TA12
    Conserved Domains (2) summary
    pfam04118
    Location:13 → 295
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:2082 → 2318
    Dopey_N; Dopey, N-terminal

  23. XM_047418433.1 → XP_047274389.1  protein dopey-1 isoform X6

  24. XM_047418432.1 → XP_047274388.1  protein dopey-1 isoform X4

  25. XM_047418438.1 → XP_047274394.1  protein dopey-1 isoform X8

  26. XM_047418439.1 → XP_047274395.1  protein dopey-1 isoform X10

  27. XM_047418444.1 → XP_047274400.1  protein dopey-1 isoform X13

  28. XM_047418452.1 → XP_047274408.1  protein dopey-1 isoform X19

  29. XM_047418453.1 → XP_047274409.1  protein dopey-1 isoform X20

  30. XM_047418455.1 → XP_047274411.1  protein dopey-1 isoform X24

  31. XM_017010573.1 → XP_016866062.1  protein dopey-1 isoform X21

    UniProtKB/TrEMBL
    B2RWN9

  32. XM_017010574.1 → XP_016866063.1  protein dopey-1 isoform X22

    UniProtKB/TrEMBL
    B2RWN9

  33. XM_047418454.1 → XP_047274410.1  protein dopey-1 isoform X23

  34. XM_047418428.1 → XP_047274384.1  protein dopey-1 isoform X1

  35. XM_047418431.1 → XP_047274387.1  protein dopey-1 isoform X3

  36. XM_047418436.1 → XP_047274392.1  protein dopey-1 isoform X7

  37. XM_047418441.1 → XP_047274397.1  protein dopey-1 isoform X10

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    84290676..84394587
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054354754.1 → XP_054210729.1  protein dopey-1 isoform X1

  2. XM_054354763.1 → XP_054210738.1  protein dopey-1 isoform X5

  3. XM_054354774.1 → XP_054210749.1  protein dopey-1 isoform X11

  4. XM_054354780.1 → XP_054210755.1  protein dopey-1 isoform X15

  5. XM_054354781.1 → XP_054210756.1  protein dopey-1 isoform X15

  6. XM_054354770.1 → XP_054210745.1  protein dopey-1 isoform X9

  7. XM_054354775.1 → XP_054210750.1  protein dopey-1 isoform X12

  8. XM_054354776.1 → XP_054210751.1  protein dopey-1 isoform X12

  9. XM_054354784.1 → XP_054210759.1  protein dopey-1 isoform X18

  10. XM_054354759.1 → XP_054210734.1  protein dopey-1 isoform X3

  11. XM_054354765.1 → XP_054210740.1  protein dopey-1 isoform X7

  12. XM_054354757.1 → XP_054210732.1  protein dopey-1 isoform X2

  13. XM_054354768.1 → XP_054210743.1  protein dopey-1 isoform X8

  14. XM_054354772.1 → XP_054210747.1  protein dopey-1 isoform X10

  15. XM_054354778.1 → XP_054210753.1  protein dopey-1 isoform X13

  16. XM_054354783.1 → XP_054210758.1  protein dopey-1 isoform X17

  17. XM_054354755.1 → XP_054210730.1  protein dopey-1 isoform X1

  18. XM_054354760.1 → XP_054210735.1  protein dopey-1 isoform X3

  19. XM_054354766.1 → XP_054210741.1  protein dopey-1 isoform X7

  20. XM_054354782.1 → XP_054210757.1  protein dopey-1 isoform X16

  21. XM_054354779.1 → XP_054210754.1  protein dopey-1 isoform X14

  22. XM_054354758.1 → XP_054210733.1  protein dopey-1 isoform X2

  23. XM_054354764.1 → XP_054210739.1  protein dopey-1 isoform X6

  24. XM_054354762.1 → XP_054210737.1  protein dopey-1 isoform X4

  25. XM_054354769.1 → XP_054210744.1  protein dopey-1 isoform X8

  26. XM_054354771.1 → XP_054210746.1  protein dopey-1 isoform X10

  27. XM_054354777.1 → XP_054210752.1  protein dopey-1 isoform X13

  28. XM_054354785.1 → XP_054210760.1  protein dopey-1 isoform X19

  29. XM_054354786.1 → XP_054210761.1  protein dopey-1 isoform X20

  30. XM_054354790.1 → XP_054210765.1  protein dopey-1 isoform X24

  31. XM_054354787.1 → XP_054210762.1  protein dopey-1 isoform X21

  32. XM_054354788.1 → XP_054210763.1  protein dopey-1 isoform X22

  33. XM_054354789.1 → XP_054210764.1  protein dopey-1 isoform X23

  34. XM_054354756.1 → XP_054210731.1  protein dopey-1 isoform X1

  35. XM_054354761.1 → XP_054210736.1  protein dopey-1 isoform X3

  36. XM_054354767.1 → XP_054210742.1  protein dopey-1 isoform X7

  37. XM_054354773.1 → XP_054210748.1  protein dopey-1 isoform X10

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5JWR5.1 GenPept UniProtKB/Swiss-Prot:Q5JWR5

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