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Conserved domains on  [gi|1882652704|ref|NP_001372788|]
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protein dopey-1 isoform f [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Dopey_N super family cl04407
Dopey, N-terminal; DopA is the founding member of the Dopey family and is required for correct ...
 1816-1976 3.73e-13

Dopey, N-terminal; DopA is the founding member of the Dopey family and is required for correct cell morphology and spatiotemporal organization of multicellular structures in the filamentous fungus Aspergillus nidulans. DopA homologs are found in mammals. S. cerevisiae DOP1 is essential for viability and, affects cellular morphogenesis.


The actual alignment was detected with superfamily member COG5221:

Pssm-ID: 471021  Cd Length: 1618  Bit Score: 75.35  E-value: 3.73e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1882652704 1816 VQLLSSLSGYQYTRRAWKKEAFDLFMDPSFFQMDASCVNHWRAIMDNLMTHDKTTFRDLMTRVavaQSSSLNLFANRDVE 1895
Cdd:COG5221   1325 LNLLAVLSERGLEVKSWRKEFVEIFNDLDLFIYGSDQLHKKSSLMRKVVVEDPSILNDLIVRL---DSGLITFFVSQDSD 1401

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1882652704 1896 LEQRAMLLKRLAFAIFSSEIDQYQKYLPDIQERLVESLRLPQVpTLHSQVFLFFRVLLLRMSPQHLTSLWPTMITELVQV 1975
Cdd:COG5221   1402 ANNKTLNLKRISYLIFSSPYDYFLGFSLKLIEKIATLMNSPSS-KLKKEVFLLSRMLILRISHDHLGNLWPILLYDLGIV 1480


                   .
gi 1882652704 1976 F 1976
Cdd:COG5221   1481 V 1481
Dopey_N super family cl04407
Dopey, N-terminal; DopA is the founding member of the Dopey family and is required for correct ...
 1-29 9.60e-09

Dopey, N-terminal; DopA is the founding member of the Dopey family and is required for correct cell morphology and spatiotemporal organization of multicellular structures in the filamentous fungus Aspergillus nidulans. DopA homologs are found in mammals. S. cerevisiae DOP1 is essential for viability and, affects cellular morphogenesis.


The actual alignment was detected with superfamily member pfam04118:

Pssm-ID: 471021  Cd Length: 302  Bit Score: 59.06  E-value: 9.60e-09
                           10        20
                   ....*....|....*....|....*....
gi 1882652704    1 MIRILSAALHVVLRRDMSLNRRLYAWLLG 29
Cdd:pfam04118  271 KELLVEAALKVVLRRDMSLNRRLWSWLLG 299
 
Name Accession Description Interval E-value
DOP1 COG5221
Dopey and related predicted leucine zipper transcription factors [Transcription];
1816-1976 3.73e-13

Dopey and related predicted leucine zipper transcription factors [Transcription];


Pssm-ID: 227546  Cd Length: 1618  Bit Score: 75.35  E-value: 3.73e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1882652704 1816 VQLLSSLSGYQYTRRAWKKEAFDLFMDPSFFQMDASCVNHWRAIMDNLMTHDKTTFRDLMTRVavaQSSSLNLFANRDVE 1895
Cdd:COG5221   1325 LNLLAVLSERGLEVKSWRKEFVEIFNDLDLFIYGSDQLHKKSSLMRKVVVEDPSILNDLIVRL---DSGLITFFVSQDSD 1401

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1882652704 1896 LEQRAMLLKRLAFAIFSSEIDQYQKYLPDIQERLVESLRLPQVpTLHSQVFLFFRVLLLRMSPQHLTSLWPTMITELVQV 1975
Cdd:COG5221   1402 ANNKTLNLKRISYLIFSSPYDYFLGFSLKLIEKIATLMNSPSS-KLKKEVFLLSRMLILRISHDHLGNLWPILLYDLGIV 1480


                   .
gi 1882652704 1976 F 1976
Cdd:COG5221   1481 V 1481
Dopey_N pfam04118
Dopey, N-terminal; DopA is the founding member of the Dopey family and is required for correct ...
 1-29 9.60e-09

Dopey, N-terminal; DopA is the founding member of the Dopey family and is required for correct cell morphology and spatiotemporal organization of multicellular structures in the filamentous fungus Aspergillus nidulans. DopA homologs are found in mammals. S. cerevisiae DOP1 is essential for viability and, affects cellular morphogenesis.


Pssm-ID: 461183  Cd Length: 302  Bit Score: 59.06  E-value: 9.60e-09
                           10        20
                   ....*....|....*....|....*....
gi 1882652704    1 MIRILSAALHVVLRRDMSLNRRLYAWLLG 29
Cdd:pfam04118  271 KELLVEAALKVVLRRDMSLNRRLWSWLLG 299
DOP1 COG5221
Dopey and related predicted leucine zipper transcription factors [Transcription];
7-114 4.27e-06

Dopey and related predicted leucine zipper transcription factors [Transcription];


Pssm-ID: 227546  Cd Length: 1618  Bit Score: 52.24  E-value: 4.27e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1882652704    7 AALHVVLRRDMSLNRRLYAWLLGFDNNGAIIgprSTRHSNPEEHATYYFTTFSKELLVQAMVGILQvngfgEENTLMQDL 86
Cdd:COG5221    277 SVIKLFLKRDLSLNRRIYGWLCGAMDSFDEV---NVSLLSRALKRNLDRGSAEIQLFFEGMMDLLS-----KGKLCESIM 348

                           90       100
                   ....*....|....*....|....*...
gi 1882652704   87 KPFRILISLLDKPELGPVILEDVLIEVF 114
Cdd:COG5221    349 EAFRIDIAECDRRHERDYIEEYAPPDAF 376
 
Name Accession Description Interval E-value
DOP1 COG5221
Dopey and related predicted leucine zipper transcription factors [Transcription];
1816-1976 3.73e-13

Dopey and related predicted leucine zipper transcription factors [Transcription];


Pssm-ID: 227546  Cd Length: 1618  Bit Score: 75.35  E-value: 3.73e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1882652704 1816 VQLLSSLSGYQYTRRAWKKEAFDLFMDPSFFQMDASCVNHWRAIMDNLMTHDKTTFRDLMTRVavaQSSSLNLFANRDVE 1895
Cdd:COG5221   1325 LNLLAVLSERGLEVKSWRKEFVEIFNDLDLFIYGSDQLHKKSSLMRKVVVEDPSILNDLIVRL---DSGLITFFVSQDSD 1401

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1882652704 1896 LEQRAMLLKRLAFAIFSSEIDQYQKYLPDIQERLVESLRLPQVpTLHSQVFLFFRVLLLRMSPQHLTSLWPTMITELVQV 1975
Cdd:COG5221   1402 ANNKTLNLKRISYLIFSSPYDYFLGFSLKLIEKIATLMNSPSS-KLKKEVFLLSRMLILRISHDHLGNLWPILLYDLGIV 1480


                   .
gi 1882652704 1976 F 1976
Cdd:COG5221   1481 V 1481
Dopey_N pfam04118
Dopey, N-terminal; DopA is the founding member of the Dopey family and is required for correct ...
 1-29 9.60e-09

Dopey, N-terminal; DopA is the founding member of the Dopey family and is required for correct cell morphology and spatiotemporal organization of multicellular structures in the filamentous fungus Aspergillus nidulans. DopA homologs are found in mammals. S. cerevisiae DOP1 is essential for viability and, affects cellular morphogenesis.


Pssm-ID: 461183  Cd Length: 302  Bit Score: 59.06  E-value: 9.60e-09
                           10        20
                   ....*....|....*....|....*....
gi 1882652704    1 MIRILSAALHVVLRRDMSLNRRLYAWLLG 29
Cdd:pfam04118  271 KELLVEAALKVVLRRDMSLNRRLWSWLLG 299
DOP1 COG5221
Dopey and related predicted leucine zipper transcription factors [Transcription];
7-114 4.27e-06

Dopey and related predicted leucine zipper transcription factors [Transcription];


Pssm-ID: 227546  Cd Length: 1618  Bit Score: 52.24  E-value: 4.27e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1882652704    7 AALHVVLRRDMSLNRRLYAWLLGFDNNGAIIgprSTRHSNPEEHATYYFTTFSKELLVQAMVGILQvngfgEENTLMQDL 86
Cdd:COG5221    277 SVIKLFLKRDLSLNRRIYGWLCGAMDSFDEV---NVSLLSRALKRNLDRGSAEIQLFFEGMMDLLS-----KGKLCESIM 348

                           90       100
                   ....*....|....*....|....*...
gi 1882652704   87 KPFRILISLLDKPELGPVILEDVLIEVF 114
Cdd:COG5221    349 EAFRIDIAECDRRHERDYIEEYAPPDAF 376
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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