Obp2a odorant binding protein 2A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Obp2aprovided by MGI
Official Full Name: odorant binding protein 2Aprovided by MGI
Primary source: MGI:MGI:2387617
See related: Ensembl:ENSMUSG00000062061 AllianceGenome:MGI:2387617
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lcn13
Summary: Predicted to enable small molecule binding activity. Acts upstream of or within several processes, including insulin receptor signaling pathway; negative regulation of gluconeogenesis; and regulation of lipid metabolic process. Located in extracellular space. Orthologous to human OBP2A (odorant binding protein 2A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in genital fat pad adult (RPKM 6.0), adrenal adult (RPKM 1.1) and 1 other tissue See more
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Genomic context

Location:: 2 A3; 2 17.8 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (25587589..25593338)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (25697577..25703326)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Elevated expression of LCN13 through FXR activation ameliorates hepatocellular lipid accumulation and inflammation.
Title: Elevated expression of LCN13 through FXR activation ameliorates hepatocellular lipid accumulation and inflammation.
Lipocalin 13 enhances insulin secretion but is dispensable for systemic metabolic control.
Title: Lipocalin 13 enhances insulin secretion but is dispensable for systemic metabolic control.
LCN13 decreases liver lipid levels by both inhibiting hepatic lipogenesis and stimulating beta-oxidation
Title: Lipocalin 13 protein protects against hepatic steatosis by both inhibiting lipogenesis and stimulating fatty acid β-oxidation.
LCN13 regulates glucose metabolism by both insulin-dependent and insulin-independent mechanisms.
Title: Lipocalin-13 regulates glucose metabolism by both insulin-dependent and insulin-independent mechanisms.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables small molecule binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within glucose homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of gluconeogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of lipid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of fatty acid beta-oxidation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of glucose metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: odorant-binding protein 2a

Names: epididymal-specific lipocalin-13; lipocalin 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.