U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

mtf1 metal-regulatory transcription factor 1 [ Danio rerio (zebrafish) ]

Gene ID: 195821, updated on 17-Aug-2024

Summary

Go to the top of the page Help
Official Symbol
mtf1provided by ZNC
Official Full Name
metal-regulatory transcription factor 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-020424-1
See related
Ensembl:ENSDARG00000102898 AllianceGenome:ZFIN:ZDB-GENE-020424-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
MTF-1
Summary
Predicted to enable metal ion binding activity. Acts upstream of or within cellular response to cadmium ion and cellular response to zinc ion. Located in cytoplasm and nucleus. Is expressed in several structures, including digestive system; female organism; heart; male organism; and spleen. Orthologous to human MTF1 (metal regulatory transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See mtf1 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (4133793..4168891)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (3819099..4337174)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene putative protein TPRXL Neighboring gene inositol polyphosphate-5-phosphatase B Neighboring gene uncharacterized LOC100535213 Neighboring gene yrdC N(6)-threonylcarbamoyltransferase domain containing

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Zinc-controlled gene expression by metal-regulatory transcription factor 1 (MTF1) in a model vertebrate, the zebrafish. Hogstrand C, et al. Biochem Soc Trans, 2008 Dec. PMID 19021535
  2. Characterization of the MTF-1 transcription factor from zebrafish and trout cells. Dalton TP, et al. Comp Biochem Physiol B Biochem Mol Biol, 2000 Jul. PMID 11007174
  3. Cytotoxicities and induction of metallothionein (MT) and metal regulatory element (MRE)-binding transcription factor-1 (MTF-1) messenger RNA levels in the zebrafish (Danio rerio) ZFL and SJD cell lines after exposure to various metal ions. Cheuk WK, et al. Aquat Toxicol, 2008 Aug 29. PMID 18639347
  4. Morphofunctional Alterations in Zebrafish (Danio rerio) Gills after Exposure to Mercury Chloride. Macirella R, et al. Int J Mol Sci, 2017 Apr 13. PMID 28406445, Free PMC Article
  5. Expression pattern of metallothionein, MTF-1 nuclear translocation, and its dna-binding activity in zebrafish (Danio rerio) induced by zinc and cadmium. Chen WY, et al. Environ Toxicol Chem, 2007 Jan. PMID 17269467

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The functional characterization of a complete zebrafish MTF-1, is reported.
    Title: Inhibition of endogenous MTF-1 signaling in zebrafish embryos identifies novel roles for MTF-1 in development.
  2. MTF1 is a master regulator of gene expression during development.
    Title: Zinc-controlled gene expression by metal-regulatory transcription factor 1 (MTF1) in a model vertebrate, the zebrafish.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to cadmium ion IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cellular response to zinc ion IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to cadmium ion IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to cadmium ion IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within response to zinc ion IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to zinc ion IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
metal regulatory transcription factor 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152981.1 → NP_694513.1  metal regulatory transcription factor 1

    See identical proteins and their annotated locations for NP_694513.1

    Status: PROVISIONAL

    Source sequence(s)
    AF458116
    UniProtKB/TrEMBL
    Q8QGH4
    Related
    ENSDARP00000146080.1, ENSDART00000192403.1
    Conserved Domains (3) summary
    COG5048
    Location:140 → 322
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:245 → 264
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:256 → 282
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    4133793..4168891
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021466610.1 → XP_021322285.1  metal regulatory transcription factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2KFP7, A0A8M9PM66
    Related
    ENSDARP00000148642.1, ENSDART00000175718.2
    Conserved Domains (2) summary
    COG5048
    Location:185 → 349
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:272 → 291
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_021466611.1 → XP_021322286.1  metal regulatory transcription factor 1 isoform X2

    UniProtKB/TrEMBL
    A0A0B5H7U7, A0A8M9PJ79
    Related
    ENSDARP00000145940.1, ENSDART00000193036.1
    Conserved Domains (2) summary
    COG5048
    Location:140 → 322
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:245 → 264
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.