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Conserved domains on  [gi|23308647|ref|NP_694513|]
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metal regulatory transcription factor 1 [Danio rerio]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
140-322 6.56e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 6.56e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308647 140 CPETKQREVKRYQClfEGCTRTYSTAGNLRTHQKT--HRGEY--TFVCNQQGCGKAFLTSYSLKIHVRVHTKEKPFECDV 215
Cdd:COG5048 279 DSSSEKGFSLPIKS--KQCNISFSRSSPLTRHLRSvnHSGESlkPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKL 356

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308647 216 QGCEKAFNTL------YRLKAHQRLHTGKTFNCESEGCTKYFTTLSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKT 289
Cdd:COG5048 357 LNSSSKFSPLlnneppQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIP 436

                       170       180       190
                ....*....|....*....|....*....|...
gi 23308647 290 HVRTHTgEKPFFCPSdgCEKTFSSQYSLKSHIR 322
Cdd:COG5048 437 HKKIHT-NHAPLLCS--ILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
268-404 1.06e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 1.06e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308647 268 KPFRCDhdGCGKAFAASHHLKTHVRTHTGEKPFFCPSDGCEKTFSSQYSLKSHIRGHDKGPSFTVS--GHPLSEDANHSL 345
Cdd:COG5048  32 RPDSCP--NCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSksLPLSNSKASSSS 109

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 23308647 346 cLSDLSLISTDSELQENHNSQGLDLNSVTPIRIFELMFQ----SPENSVSEDDPKPTESLAES 404
Cdd:COG5048 110 -LSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRnnplPGNNSSSVNTPQSNSLHPPL 171
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
140-322 6.56e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 6.56e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308647 140 CPETKQREVKRYQClfEGCTRTYSTAGNLRTHQKT--HRGEY--TFVCNQQGCGKAFLTSYSLKIHVRVHTKEKPFECDV 215
Cdd:COG5048 279 DSSSEKGFSLPIKS--KQCNISFSRSSPLTRHLRSvnHSGESlkPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKL 356

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308647 216 QGCEKAFNTL------YRLKAHQRLHTGKTFNCESEGCTKYFTTLSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKT 289
Cdd:COG5048 357 LNSSSKFSPLlnneppQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIP 436

                       170       180       190
                ....*....|....*....|....*....|...
gi 23308647 290 HVRTHTgEKPFFCPSdgCEKTFSSQYSLKSHIR 322
Cdd:COG5048 437 HKKIHT-NHAPLLCS--ILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
268-404 1.06e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 1.06e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308647 268 KPFRCDhdGCGKAFAASHHLKTHVRTHTGEKPFFCPSDGCEKTFSSQYSLKSHIRGHDKGPSFTVS--GHPLSEDANHSL 345
Cdd:COG5048  32 RPDSCP--NCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSksLPLSNSKASSSS 109

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 23308647 346 cLSDLSLISTDSELQENHNSQGLDLNSVTPIRIFELMFQ----SPENSVSEDDPKPTESLAES 404
Cdd:COG5048 110 -LSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRnnplPGNNSSSVNTPQSNSLHPPL 171
zf-H2C2_2 pfam13465
Zinc-finger double domain;
256-282 1.12e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.36  E-value: 1.12e-05
                          10        20
                  ....*....|....*....|....*..
gi 23308647   256 DLRKHIRTHTGEKPFRCDHdgCGKAFA 282
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFK 25
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
140-322 6.56e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 6.56e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308647 140 CPETKQREVKRYQClfEGCTRTYSTAGNLRTHQKT--HRGEY--TFVCNQQGCGKAFLTSYSLKIHVRVHTKEKPFECDV 215
Cdd:COG5048 279 DSSSEKGFSLPIKS--KQCNISFSRSSPLTRHLRSvnHSGESlkPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKL 356

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308647 216 QGCEKAFNTL------YRLKAHQRLHTGKTFNCESEGCTKYFTTLSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKT 289
Cdd:COG5048 357 LNSSSKFSPLlnneppQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIP 436

                       170       180       190
                ....*....|....*....|....*....|...
gi 23308647 290 HVRTHTgEKPFFCPSdgCEKTFSSQYSLKSHIR 322
Cdd:COG5048 437 HKKIHT-NHAPLLCS--ILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
159-343 4.77e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 4.77e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308647 159 TRTYSTAGNLRTHQKTHRGEYTFvCNQQGCGKAFLTSYSLKIHVR--VHTKE--KPFECDVQGCEKAFNTLYRLKAHQRL 234
Cdd:COG5048 267 TASSQSSSPNESDSSSEKGFSLP-IKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYSLCGKLFSRNDALKRHILL 345

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308647 235 HTGKTFNCE-SEGCTKYFTTLSDLRKH-----IRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGEKPFFCPSDGCE 308
Cdd:COG5048 346 HTSISPAKEkLLNSSSKFSPLLNNEPPqslqqYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCS 425

                       170       180       190
                ....*....|....*....|....*....|....*
gi 23308647 309 KTFSSQYSLKSHIRGHDKGPSFTVSGHPLSEDANH 343
Cdd:COG5048 426 KSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
268-404 1.06e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 1.06e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308647 268 KPFRCDhdGCGKAFAASHHLKTHVRTHTGEKPFFCPSDGCEKTFSSQYSLKSHIRGHDKGPSFTVS--GHPLSEDANHSL 345
Cdd:COG5048  32 RPDSCP--NCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSksLPLSNSKASSSS 109

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 23308647 346 cLSDLSLISTDSELQENHNSQGLDLNSVTPIRIFELMFQ----SPENSVSEDDPKPTESLAES 404
Cdd:COG5048 110 -LSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRnnplPGNNSSSVNTPQSNSLHPPL 171
zf-H2C2_2 pfam13465
Zinc-finger double domain;
256-282 1.12e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.36  E-value: 1.12e-05
                          10        20
                  ....*....|....*....|....*..
gi 23308647   256 DLRKHIRTHTGEKPFRCDHdgCGKAFA 282
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
286-313 5.15e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 5.15e-05
                          10        20
                  ....*....|....*....|....*...
gi 23308647   286 HLKTHVRTHTGEKPFFCPSdgCEKTFSS 313
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 242-321 6.65e-05

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 42.02  E-value: 6.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308647   242 CESEGCTKYFTTLSDLRKHIRTHTGE------KPFRCDHDGCGKAFAASHHLKTHVRTHTGEKPFFcPSDGCEKTFSSQY 315
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHCPPtqslegKLFRCSALSCTETFPSMQELVAHSKLHYKPNRYF-KCENCLLRFRTHR 80


                  ....*.
gi 23308647   316 SLKSHI 321
Cdd:pfam15909  81 SLFKHL 86
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
188-415 1.56e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.56e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308647 188 CGKAFLTSYSLKIHVRVHTKEKPFECDVQGCEKAFNTLYRLKAHQRLHTG---------------KTFNCESEGCTKYFT 252
Cdd:COG5048  39 CTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNnpsdlnskslplsnsKASSSSLSSSSSNSN 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308647 253 TLSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGEKPFF---CPSDGCEKTFSSQYSLKSHIRGHDKGPS 329
Cdd:COG5048 119 DNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLhppLPANSLSKDPSSNLSLLISSNVSTSIPS 198

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308647 330 FTVSGHPLSEDANHSLcLSDLSLISTDSELQENHNSQGLDLNSVTPIRIFE---LMFQSPENSVSEDDPKPTESLAESFG 406
Cdd:COG5048 199 SSENSPLSSSYSIPSS-SSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLsssDSSSSASESPRSSLPTASSQSSSPNE 277


                ....*....
gi 23308647 407 LEPSPQSAP 415
Cdd:COG5048 278 SDSSSEKGF 286
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 208-295 1.86e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 1.86e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308647 208 EKPFECDVQGCEKAFNTLYRLKAHqRLHTgktfnceseGCTKYFTTLSDLRKHIRTHTGEKPFRCDHdgCGKAFAASHHL 287
Cdd:COG5189 347 GKPYKCPVEGCNKKYKNQNGLKYH-MLHG---------HQNQKLHENPSPEKMNIFSAKDKPYRCEV--CDKRYKNLNGL 414


                ....*...
gi 23308647 288 KTHvRTHT 295
Cdd:COG5189 415 KYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
197-224 2.81e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.81e-04
                          10        20
                  ....*....|....*....|....*...
gi 23308647   197 SLKIHVRVHTKEKPFECDVqgCEKAFNT 224
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 183-261 3.29e-04

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 40.10  E-value: 3.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308647   183 CNQQGCGKAFLTSYSLKIHVRVHT------KEKPFECDVQGCEKAFNTLYRLKAHQRLH--TGKTFNCESegCTKYFTTL 254
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHCpptqslEGKLFRCSALSCTETFPSMQELVAHSKLHykPNRYFKCEN--CLLRFRTH 79


                  ....*..
gi 23308647   255 SDLRKHI 261
Cdd:pfam15909  80 RSLFKHL 86
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 296-324 4.55e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 4.55e-03
                        10        20        30
                ....*....|....*....|....*....|
gi 23308647 296 GEKPFFCPSDGCEKTFSSQYSLKSH-IRGH 324
Cdd:COG5189 346 DGKPYKCPVEGCNKKYKNQNGLKYHmLHGH 375
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 270-294 6.73e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 6.73e-03
                          10        20
                  ....*....|....*....|....*
gi 23308647   270 FRCDHdgCGKAFAASHHLKTHVRTH 294
Cdd:pfam00096   1 YKCPD--CGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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