itr-1 Inositol 1,4,5-trisphosphate receptor itr-1 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: itr-1
Gene description: Inositol 1,4,5-trisphosphate receptor itr-1
Locus tag: CELE_F33D4.2
See related: AllianceGenome:WB:WBGene00002173
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables myosin binding activity. Involved in several processes, including hermaphrodite genitalia morphogenesis; mating; and positive regulation of pharyngeal pumping. Located in endoplasmic reticulum and membrane. Is expressed in several structures, including epithelial cell; ganglia; gonad; non-striated muscle; and pharynx. Human ortholog(s) of this gene implicated in Gillespie syndrome; isolated anhidrosis with normal sweat glands; neurodegenerative disease (multiple); and type 1 diabetes mellitus. Orthologous to several human genes including ITPR1 (inositol 1,4,5-trisphosphate receptor type 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See itr-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 38

Sequence:: Chromosome: IV; NC_003282.8 (7675174..7696930)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F33D4.2 (e-PCR)
- UniSTS:317483

STS4-147 (e-PCR)
- UniSTS:242136

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables calcium channel activity	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables inositol 1,4,5 trisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables inositol 1,4,5 trisphosphate binding	IEA Inferred from Electronic Annotation more info
enables inositol 1,4,5-trisphosphate-gated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol 1,4,5-trisphosphate-gated calcium channel activity	IEA Inferred from Electronic Annotation more info
enables inositol 1,4,5-trisphosphate-gated calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables myosin binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphatidylinositol binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in defecation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in defecation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male mating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in multicellular organismal reproductive process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte maturation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of nematode pharyngeal pumping	IPI Inferred from Physical Interaction more info	PubMed
involved_in programmed cell death	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of nematode pharyngeal pumping	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of nematode pharyngeal pumping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in release of sequestered calcium ion into cytosol	IBA Inferred from Biological aspect of Ancestor more info
involved_in rhythmic behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sperm ejaculation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in sarcoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
is_active_in secretory granule membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Inositol 1,4,5-trisphosphate receptor itr-1

NP_001023170.1

Confirmed by transcript evidence

NP_001023171.1

Confirmed by transcript evidence

NP_001023172.1

Confirmed by transcript evidence

NP_001023173.1

Confirmed by transcript evidence

NP_001255305.1

Confirmed by transcript evidence

NP_001367466.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

7675174..7696930

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001027999.4 → NP_001023170.1 Inositol 1,4,5-trisphosphate receptor itr-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023170.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3NQ87, G5EBF6, Q8MXI9, Q9U3B3, Q9Y0A0, Q9Y0A1

Conserved Domains (8) summary

TIGR04370
Location:2452 → 2640

glyco_rpt_poly; oligosaccharide repeat unit polymerase

pfam00520
Location:2570 → 2764

Ion_trans; Ion transport protein

pfam01365
Location:593 → 787

RYDR_ITPR; RIH domain

pfam02815
Location:320 → 548

MIR; MIR domain

pfam06432
Location:2447 → 2539

GPI2; Phosphatidylinositol N-acetylglucosaminyltransferase

pfam08454
Location:2073 → 2176

RIH_assoc; RyR and IP3R Homology associated

pfam08709
Location:78 → 312

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

cl01736
Location:2507 → 2636

PelG; Putative exopolysaccharide Exporter (EPS-E)
NM_001028000.5 → NP_001023171.1 Inositol 1,4,5-trisphosphate receptor itr-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023171.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9Y0A1

Conserved Domains (8) summary

TIGR04370
Location:2396 → 2584

glyco_rpt_poly; oligosaccharide repeat unit polymerase

pfam00520
Location:2514 → 2708

Ion_trans; Ion transport protein

pfam01365
Location:537 → 731

RYDR_ITPR; RIH domain

pfam02815
Location:264 → 492

MIR; MIR domain

pfam06432
Location:2391 → 2483

GPI2; Phosphatidylinositol N-acetylglucosaminyltransferase

pfam08454
Location:2017 → 2120

RIH_assoc; RyR and IP3R Homology associated

pfam08709
Location:22 → 256

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

cl01736
Location:2451 → 2580

PelG; Putative exopolysaccharide Exporter (EPS-E)
NM_001028001.5 → NP_001023172.1 Inositol 1,4,5-trisphosphate receptor itr-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023172.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9Y0A1

Conserved Domains (8) summary

TIGR04370
Location:2417 → 2605

glyco_rpt_poly; oligosaccharide repeat unit polymerase

pfam00520
Location:2535 → 2729

Ion_trans; Ion transport protein

pfam01365
Location:556 → 750

RYDR_ITPR; RIH domain

pfam02815
Location:274 → 511

MIR; MIR domain

pfam06432
Location:2412 → 2504

GPI2; Phosphatidylinositol N-acetylglucosaminyltransferase

pfam08454
Location:2038 → 2141

RIH_assoc; RyR and IP3R Homology associated

pfam08709
Location:32 → 266

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

cl01736
Location:2472 → 2601

PelG; Putative exopolysaccharide Exporter (EPS-E)
NM_001028002.4 → NP_001023173.1 Inositol 1,4,5-trisphosphate receptor itr-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023173.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9Y0A1

Conserved Domains (8) summary

TIGR04370
Location:2406 → 2594

glyco_rpt_poly; oligosaccharide repeat unit polymerase

pfam00520
Location:2524 → 2718

Ion_trans; Ion transport protein

pfam01365
Location:547 → 741

RYDR_ITPR; RIH domain

pfam02815
Location:274 → 502

MIR; MIR domain

pfam06432
Location:2401 → 2493

GPI2; Phosphatidylinositol N-acetylglucosaminyltransferase

pfam08454
Location:2027 → 2130

RIH_assoc; RyR and IP3R Homology associated

pfam08709
Location:32 → 266

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

cl01736
Location:2461 → 2590

PelG; Putative exopolysaccharide Exporter (EPS-E)
NM_001268376.4 → NP_001255305.1 Inositol 1,4,5-trisphosphate receptor itr-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255305.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9Y0A1

Conserved Domains (8) summary

TIGR04370
Location:2427 → 2615

glyco_rpt_poly; oligosaccharide repeat unit polymerase

pfam00520
Location:2545 → 2739

Ion_trans; Ion transport protein

pfam01365
Location:547 → 741

RYDR_ITPR; RIH domain

pfam02815
Location:274 → 502

MIR; MIR domain

pfam06432
Location:2422 → 2514

GPI2; Phosphatidylinositol N-acetylglucosaminyltransferase

pfam08454
Location:2048 → 2151

RIH_assoc; RyR and IP3R Homology associated

pfam08709
Location:32 → 266

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

cl01736
Location:2482 → 2611

PelG; Putative exopolysaccharide Exporter (EPS-E)
NM_001380339.2 → NP_001367466.1 Inositol 1,4,5-trisphosphate receptor itr-1 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (3) summary

pfam01365
Location:545 → 746

RYDR_ITPR; RIH domain

pfam02815
Location:274 → 502

MIR; MIR domain

pfam08709
Location:32 → 271

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor