pfam08709: Ins145_P3_rec (this model, PSSM-Id:400861 is obsolete and has been replaced by 462572)
Inositol 1,4,5-trisphosphate/ryanodine receptor
This domain corresponds to the ligand binding region on inositol 1,4,5-trisphosphate receptor, and the N terminal region of the ryanodine receptor. Both receptors are involved in Ca2+ release. They can couple to the activation of neurotransmitter-gated receptors and voltage-gated Ca2+ channels on the plasma membrane, thus allowing the endoplasmic reticulum discriminate between different types of neuronal activity.
Jiyao W et al.(2023). "The conserved domain database in 2023.",