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Usp15 ubiquitin specific peptidase 15 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171329, updated on 28-Oct-2024

Summary

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Official Symbol
Usp15provided by RGD
Official Full Name
ubiquitin specific peptidase 15provided by RGD
Primary source
RGD:628795
See related
EnsemblRapid:ENSRNOG00000023202 AllianceGenome:RGD:628795
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ubp109
Summary
Enables cysteine-type deubiquitinase activity. Involved in protein deubiquitination. Located in cytoplasm and nucleus. Orthologous to human USP15 (ubiquitin specific peptidase 15). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Muscle (RPKM 335.8), Spleen (RPKM 270.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Usp15 in Genome Data Viewer
Location:
7q22
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (60643611..60805137, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (58756714..58848778, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (66595707..66687707)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene SNRPN upstream reading frame protein-like Neighboring gene MON2 homolog, regulator of endosome-to-Golgi trafficking Neighboring gene SNRPN upstream open reading frame like 1 Neighboring gene uncharacterized LOC134479704 Neighboring gene small nucleolar RNA, H/ACA box 19 Neighboring gene uncharacterized LOC134479703 Neighboring gene uncharacterized LOC134479705 Neighboring gene TAFA chemokine like family member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Tissue-specificity, functional characterization and subcellular localization of a rat ubiquitin-specific processing protease, UBP109, whose mRNA expression is developmentally regulated. Park KC, et al. Biochem J, 2000 Jul 15. PMID 10880343, Free PMC Article
  2. USP15 participates in DBP-induced testicular oxidative stress injury through regulating the Keap1/Nrf2 signaling pathway. Zhang L, et al. Sci Total Environ, 2021 Aug 20. PMID 34088152
  3. Alleviative effect of microRNA-497 on diabetic neuropathic pain in rats in relation to decreased USP15. Zhang T, et al. Cell Biol Toxicol, 2023 Oct. PMID 35478295
  4. Inhibition of USP15 Prevent Glutamate-Induced Oxidative Damage by Activating Nrf2/HO-1 Signaling Pathway in HT22 Cells. Chen X, et al. Cell Mol Neurobiol, 2020 Aug. PMID 31933062
  5. The zinc finger of the CSN-associated deubiquitinating enzyme USP15 is essential to rescue the E3 ligase Rbx1. Hetfeld BK, et al. Curr Biol, 2005 Jul 12. PMID 16005295

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Alleviative effect of microRNA-497 on diabetic neuropathic pain in rats in relation to decreased USP15.
    Title: Alleviative effect of microRNA-497 on diabetic neuropathic pain in rats in relation to decreased USP15.
  2. USP15 promotes pulmonary vascular remodeling in pulmonary hypertension in a YAP1/TAZ-dependent manner.
    Title: USP15 promotes pulmonary vascular remodeling in pulmonary hypertension in a YAP1/TAZ-dependent manner.
  3. USP15 participates in DBP-induced testicular oxidative stress injury through regulating the Keap1/Nrf2 signaling pathway.
    Title: USP15 participates in DBP-induced testicular oxidative stress injury through regulating the Keap1/Nrf2 signaling pathway.
  4. Inhibition of USP15 Prevent Glutamate-Induced Oxidative Damage by Activating Nrf2/HO-1 Signaling Pathway in HT22 Cells.
    Title: Inhibition of USP15 Prevent Glutamate-Induced Oxidative Damage by Activating Nrf2/HO-1 Signaling Pathway in HT22 Cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables K48-linked deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables K48-linked deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables SMAD binding IEA
Inferred from Electronic Annotation
more info
  
enables SMAD binding ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type endopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables transforming growth factor beta receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables transforming growth factor beta receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-modified histone reader activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-modified histone reader activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in BMP signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in monoubiquitinated protein deubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in monoubiquitinated protein deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in monoubiquitinated protein deubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of antifungal innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of antifungal innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of antifungal innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of RIG-I signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of RIG-I signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K27-linked deubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein K27-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K27-linked deubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein deubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein deubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription elongation-coupled chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription elongation-coupled chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription elongation-coupled chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription elongation-coupled chromatin remodeling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 15
Names
deubiquitinating enzyme 15
deubiquitinating enzyme Ubp109
ubiquitin carboxyl-terminal hydrolase of 109 kDa
ubiquitin specific protease 15
ubiquitin thioesterase 15
ubiquitin-specific-processing protease 15
XP_006241493.1
XP_008763598.1
XP_038934278.1
XP_038934279.1
XP_038934281.1
XP_063119023.1
XP_063119024.1
XP_063119025.1
XP_063119026.1
XP_063119027.1
XP_063119028.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001433837.1 → NP_001420766.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007

  2. NM_001433838.1 → NP_001420767.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007

  3. NM_001433839.1 → NP_001420768.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007

  4. NM_001433840.1 → NP_001420769.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007

  5. NM_001433841.1 → NP_001420770.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 6

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007

  6. NM_001433842.1 → NP_001420771.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 7

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007

  7. NM_001433843.1 → NP_001420772.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 8

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007

  8. NM_001433844.1 → NP_001420773.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 9

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007

  9. NM_001433845.1 → NP_001420774.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 10

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007

  10. NM_001433846.1 → NP_001420775.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 10

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007

  11. NM_001433847.1 → NP_001420776.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 10

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007

  12. NM_001433848.1 → NP_001420777.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 10

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007

  13. NM_001433849.1 → NP_001420778.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 10

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007

  14. NM_001433850.1 → NP_001420779.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 11

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007

  15. NM_145184.2 → NP_660185.2  ubiquitin carboxyl-terminal hydrolase 15 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    Related
    ENSRNOP00000071983.2, ENSRNOT00000079410.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    60643611..60805137 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063262953.1 → XP_063119023.1  ubiquitin carboxyl-terminal hydrolase 15 isoform X2

  2. XM_006241431.4 → XP_006241493.1  ubiquitin carboxyl-terminal hydrolase 15 isoform X1

    UniProtKB/TrEMBL
    A0A0A0MY07, A6HQN9
    Related
    ENSRNOP00000034485.6, ENSRNOT00000031191.8
    Conserved Domains (1) summary
    COG5560
    Location:12 → 932
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

  3. XM_008765376.4 → XP_008763598.1  ubiquitin carboxyl-terminal hydrolase 15 isoform X4

    Conserved Domains (4) summary
    cd02674
    Location:663 → 810
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:169 → 354
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam14533
    Location:370 → 476
    USP7_C2; Ubiquitin-specific protease C-terminal
    pfam14836
    Location:14 → 101
    Ubiquitin_3; Ubiquitin-like domain

  4. XM_039078351.2 → XP_038934279.1  ubiquitin carboxyl-terminal hydrolase 15 isoform X8

    UniProtKB/TrEMBL
    A6HQP0
    Conserved Domains (1) summary
    COG5560
    Location:34 → 683
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

  5. XM_063262956.1 → XP_063119026.1  ubiquitin carboxyl-terminal hydrolase 15 isoform X6

  6. XM_039078350.2 → XP_038934278.1  ubiquitin carboxyl-terminal hydrolase 15 isoform X7

    UniProtKB/TrEMBL
    A6HQP0
    Conserved Domains (1) summary
    COG5560
    Location:60 → 709
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

  7. XM_039078353.2 → XP_038934281.1  ubiquitin carboxyl-terminal hydrolase 15 isoform X9

    UniProtKB/TrEMBL
    A6HQP0
    Conserved Domains (1) summary
    COG5560
    Location:1 → 599
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

  8. XM_063262954.1 → XP_063119024.1  ubiquitin carboxyl-terminal hydrolase 15 isoform X3

  9. XM_063262955.1 → XP_063119025.1  ubiquitin carboxyl-terminal hydrolase 15 isoform X5

  10. XM_063262958.1 → XP_063119028.1  ubiquitin carboxyl-terminal hydrolase 15 isoform X11

  11. XM_063262957.1 → XP_063119027.1  ubiquitin carboxyl-terminal hydrolase 15 isoform X10

RNA

  1. XR_010052935.1 RNA Sequence

  2. XR_010052937.1 RNA Sequence

  3. XR_010052938.1 RNA Sequence

  4. XR_010052936.1 RNA Sequence

  5. XR_010052939.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R085.1 GenPept UniProtKB/Swiss-Prot:Q9R085

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