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ZNF600 zinc finger protein 600 [ Homo sapiens (human) ]

Gene ID: 162966, updated on 2-Nov-2024

Summary

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Official Symbol
ZNF600provided by HGNC
Official Full Name
zinc finger protein 600provided by HGNC
Primary source
HGNC:HGNC:30951
See related
Ensembl:ENSG00000189190 AllianceGenome:HGNC:30951
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KR-ZNF1
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in small intestine (RPKM 4.5), spleen (RPKM 4.0) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ZNF600 in Genome Data Viewer
Location:
19q13.41
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (52764164..52833645, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (55848625..55917941, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (53267417..53290044, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 611 Neighboring gene uncharacterized LOC124904760 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:53238285-53239270 Neighboring gene uncharacterized LOC105372452 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:53259364-53260079 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53263091-53263641 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:53285228-53285408 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:53287129-53287305 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53289004-53289862 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53289863-53290720 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:53293023-53293553 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53294085-53294614 Neighboring gene zinc finger protein 28 Neighboring gene PABPN1 pseudogene 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53324831-53325332 Neighboring gene zinc finger protein 468 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15057 Neighboring gene zinc finger protein 320 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:53379555-53380056 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15058 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15059

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Regulation of T-cell receptor D beta 1 promoter by KLF5 through reiterated GC-rich motifs. Yang XO, et al. Blood, 2003 Jun 1. PMID 12576331
  2. Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. Demirkan A, et al. PLoS Genet, 2012. PMID 22359512, Free PMC Article
  3. A human MAP kinase interactome. Bandyopadhyay S, et al. Nat Methods, 2010 Oct. PMID 20936779, Free PMC Article
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  5. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp686F06123

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 600
Names
zinc finger protein KR-ZNF1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321866.4 → NP_001308795.1  zinc finger protein 600 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008813
    Consensus CDS
    CCDS92675.1
    UniProtKB/TrEMBL
    A0A3B3IT03
    Related
    ENSP00000509267.1, ENST00000692063.1
    Conserved Domains (6) summary
    smart00349
    Location:24 → 71
    KRAB; krueppel associated box
    COG5048
    Location:341 → 748
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:317 → 337
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:707 → 729
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:24 → 60
    KRAB; KRAB box
    pfam13465
    Location:357 → 382
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001321867.3 → NP_001308796.1  zinc finger protein 600 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008813, BX640933, DB158392
    Consensus CDS
    CCDS92675.1
    UniProtKB/TrEMBL
    A0A3B3IT03
    Related
    ENSP00000497540.1, ENST00000648973.1
    Conserved Domains (6) summary
    smart00349
    Location:24 → 71
    KRAB; krueppel associated box
    COG5048
    Location:341 → 748
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:317 → 337
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:707 → 729
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:24 → 60
    KRAB; KRAB box
    pfam13465
    Location:357 → 382
    zf-H2C2_2; Zinc-finger double domain

  3. NM_198457.5 → NP_940859.3  zinc finger protein 600 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC008813, AK131231, BX640933, DB158392
    Consensus CDS
    CCDS12856.1
    UniProtKB/Swiss-Prot
    Q6MZR0, Q6ZNG1
    Related
    ENSP00000344791.2, ENST00000338230.3
    Conserved Domains (4) summary
    COG5048
    Location:272 → 679
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:248 → 268
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:638 → 660
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:288 → 313
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    52764164..52833645 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438291.1 → XP_047294247.1  zinc finger protein 600 isoform X2

  2. XM_047438297.1 → XP_047294253.1  zinc finger protein 600 isoform X1

    UniProtKB/TrEMBL
    A0A3B3IT03

  3. XM_047438294.1 → XP_047294250.1  zinc finger protein 600 isoform X1

    UniProtKB/TrEMBL
    A0A3B3IT03

  4. XM_047438299.1 → XP_047294255.1  zinc finger protein 600 isoform X3

    UniProtKB/Swiss-Prot
    Q6MZR0, Q6ZNG1

  5. XM_047438288.1 → XP_047294244.1  zinc finger protein 600 isoform X1

    UniProtKB/TrEMBL
    A0A3B3IT03

  6. XM_047438296.1 → XP_047294252.1  zinc finger protein 600 isoform X1

    UniProtKB/TrEMBL
    A0A3B3IT03

  7. XM_017026390.2 → XP_016881879.1  zinc finger protein 600 isoform X1

    UniProtKB/TrEMBL
    A0A3B3IT03
    Conserved Domains (6) summary
    smart00349
    Location:24 → 71
    KRAB; krueppel associated box
    COG5048
    Location:341 → 748
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:317 → 337
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:707 → 729
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:24 → 60
    KRAB; KRAB box
    pfam13465
    Location:357 → 382
    zf-H2C2_2; Zinc-finger double domain

  8. XM_047438298.1 → XP_047294254.1  zinc finger protein 600 isoform X1

    UniProtKB/TrEMBL
    A0A3B3IT03

  9. XM_047438295.1 → XP_047294251.1  zinc finger protein 600 isoform X1

    UniProtKB/TrEMBL
    A0A3B3IT03

  10. XM_047438292.1 → XP_047294248.1  zinc finger protein 600 isoform X1

    UniProtKB/TrEMBL
    A0A3B3IT03

  11. XM_047438289.1 → XP_047294245.1  zinc finger protein 600 isoform X1

    UniProtKB/TrEMBL
    A0A3B3IT03

  12. XM_047438293.1 → XP_047294249.1  zinc finger protein 600 isoform X1

    UniProtKB/TrEMBL
    A0A3B3IT03

  13. XM_017026392.2 → XP_016881881.1  zinc finger protein 600 isoform X1

    UniProtKB/TrEMBL
    A0A3B3IT03
    Related
    ENSP00000509375.1, ENST00000688329.1
    Conserved Domains (6) summary
    smart00349
    Location:24 → 71
    KRAB; krueppel associated box
    COG5048
    Location:341 → 748
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:317 → 337
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:707 → 729
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:24 → 60
    KRAB; KRAB box
    pfam13465
    Location:357 → 382
    zf-H2C2_2; Zinc-finger double domain

  14. XM_047438290.1 → XP_047294246.1  zinc finger protein 600 isoform X1

    UniProtKB/TrEMBL
    A0A3B3IT03

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    55848625..55917941 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320030.1 → XP_054176005.1  zinc finger protein 600 isoform X2

  2. XM_054320037.1 → XP_054176012.1  zinc finger protein 600 isoform X1

  3. XM_054320034.1 → XP_054176009.1  zinc finger protein 600 isoform X1

  4. XM_054320027.1 → XP_054176002.1  zinc finger protein 600 isoform X1

  5. XM_054320036.1 → XP_054176011.1  zinc finger protein 600 isoform X1

  6. XM_054320033.1 → XP_054176008.1  zinc finger protein 600 isoform X1

  7. XM_054320035.1 → XP_054176010.1  zinc finger protein 600 isoform X1

  8. XM_054320031.1 → XP_054176006.1  zinc finger protein 600 isoform X1

  9. XM_054320028.1 → XP_054176003.1  zinc finger protein 600 isoform X1

  10. XM_054320032.1 → XP_054176007.1  zinc finger protein 600 isoform X1

  11. XM_054320038.1 → XP_054176013.1  zinc finger protein 600 isoform X1

  12. XM_054320029.1 → XP_054176004.1  zinc finger protein 600 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZNG1.2 GenPept UniProtKB/Swiss-Prot:Q6ZNG1

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