NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1013394834|ref|NP_001308795|]
View 

zinc finger protein 600 isoform 2 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016931)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 24-60 4.75e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 80.98  E-value: 4.75e-19
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1013394834  24 LTFRDVAIEFSLAEWKCLNPSQRALYREVMLENYRNL 60
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNL 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
341-748 6.17e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.49  E-value: 6.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 341 KPYKCNECDKAFNQQSNLARHRRIHTGEKPYKC--EECDKVFSRKSTLESHKRIHTGEKPYKC-KVCDTAFTWNSQLARH 417
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 418 KRIHTGEKTYKCNECGKTFSHKSSLVCHHRLHGGEKSYKCKVCDKAFAW----NSHLVRHTRIHSGGKPYKCNECGKTFG 493
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtpqsNSLHPPLPANSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 494 QNSDLLIHKSIHTGEQPYKYeecekvfscgSTLETHKIIHTGEKPYKCKVCDKAFACHSYLAKHTRIHSGEKPYKCNECS 573
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSI----------PSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESP 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 574 KTFRL--RSYLASHRRVHSGE-----KPYKCNECSKTFSQRSYLHCHRR--LHSGE--KPYKCNE--CGKTFSHKPSLVH 640
Cdd:COG5048   262 RSSLPtaSSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKR 341

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 641 HRRLHTGEKSYKC--TVCDKAFVRNSYLARHTRIH-----TAEKPYKC--NECGKAFNQQSQLSLHHRIHA--GEKLYKC 709
Cdd:COG5048   342 HILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLsfRPYNCKN 421

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 1013394834 710 ETCDKVFSRKSHLKRHRRIHPGKKPYKCKVCDKTFGSDS 748
Cdd:COG5048   422 PPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
154-503 3.75e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 3.75e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 154 DQLGSSFYSHLPELHIIQIKGKIGNQFEKSTSDAPSVSTSQRISPRPQIHISNNYGNNSpNSSLLPQKQEVYMREKSFQC 233
Cdd:COG5048    96 KSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGN-NSSSVNTPQSNSLHPPLPAN 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 234 NESGKAFNCSSLLRKHQIPHlGDKQYKCDVCGKLFNHKQYLTCHCRCHTGEKPYKCNECGKSFSQvsSLTCHRRLHTAVK 313
Cdd:COG5048   175 SLSKDPSSNLSLLISSNVST-SIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPK--SLLSQSPSSLSSS 251

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 314 --SHKCNECGKIFGQNSALVIHKAIHTGE-------KPYKCNECDKAFNQQSNLARHRR--IHTGE--KPYKCEE--CDK 378
Cdd:COG5048   252 dsSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGK 331

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 379 VFSRKSTLESHKRIHTGEKPYKCKVCDT-------AFTWNSQLARHKRIHTGEKTYKC--NECGKTFSHKSSLVCHHRLH 449
Cdd:COG5048   332 LFSRNDALKRHILLHTSISPAKEKLLNSsskfsplLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITH 411

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1013394834 450 --GGEKSYKCKVCDKAFAWNSHLVRHTRIHSGGKPYKCNECGKTFGQNSDLLIHKS 503
Cdd:COG5048   412 lsFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
749-774 5.03e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.03e-03
                          10        20
                  ....*....|....*....|....*.
gi 1013394834 749 HLKQHTGLHTGEKPYKCNECGKAFSK 774
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 24-60 4.75e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 80.98  E-value: 4.75e-19
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1013394834  24 LTFRDVAIEFSLAEWKCLNPSQRALYREVMLENYRNL 60
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNL 38
KRAB smart00349
krueppel associated box;
24-71 2.46e-18

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 79.56  E-value: 2.46e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1013394834   24 LTFRDVAIEFSLAEWKCLNPSQRALYREVMLENYRNLEAVD--ISSKRMM 71
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGfqVPKPDLI 50
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 24-60 2.73e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 72.97  E-value: 2.73e-16
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1013394834  24 LTFRDVAIEFSLAEWKCLNPSQRALYREVMLENYRNL 60
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
341-748 6.17e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.49  E-value: 6.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 341 KPYKCNECDKAFNQQSNLARHRRIHTGEKPYKC--EECDKVFSRKSTLESHKRIHTGEKPYKC-KVCDTAFTWNSQLARH 417
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 418 KRIHTGEKTYKCNECGKTFSHKSSLVCHHRLHGGEKSYKCKVCDKAFAW----NSHLVRHTRIHSGGKPYKCNECGKTFG 493
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtpqsNSLHPPLPANSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 494 QNSDLLIHKSIHTGEQPYKYeecekvfscgSTLETHKIIHTGEKPYKCKVCDKAFACHSYLAKHTRIHSGEKPYKCNECS 573
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSI----------PSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESP 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 574 KTFRL--RSYLASHRRVHSGE-----KPYKCNECSKTFSQRSYLHCHRR--LHSGE--KPYKCNE--CGKTFSHKPSLVH 640
Cdd:COG5048   262 RSSLPtaSSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKR 341

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 641 HRRLHTGEKSYKC--TVCDKAFVRNSYLARHTRIH-----TAEKPYKC--NECGKAFNQQSQLSLHHRIHA--GEKLYKC 709
Cdd:COG5048   342 HILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLsfRPYNCKN 421

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 1013394834 710 ETCDKVFSRKSHLKRHRRIHPGKKPYKCKVCDKTFGSDS 748
Cdd:COG5048   422 PPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
154-503 3.75e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 3.75e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 154 DQLGSSFYSHLPELHIIQIKGKIGNQFEKSTSDAPSVSTSQRISPRPQIHISNNYGNNSpNSSLLPQKQEVYMREKSFQC 233
Cdd:COG5048    96 KSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGN-NSSSVNTPQSNSLHPPLPAN 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 234 NESGKAFNCSSLLRKHQIPHlGDKQYKCDVCGKLFNHKQYLTCHCRCHTGEKPYKCNECGKSFSQvsSLTCHRRLHTAVK 313
Cdd:COG5048   175 SLSKDPSSNLSLLISSNVST-SIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPK--SLLSQSPSSLSSS 251

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 314 --SHKCNECGKIFGQNSALVIHKAIHTGE-------KPYKCNECDKAFNQQSNLARHRR--IHTGE--KPYKCEE--CDK 378
Cdd:COG5048   252 dsSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGK 331

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 379 VFSRKSTLESHKRIHTGEKPYKCKVCDT-------AFTWNSQLARHKRIHTGEKTYKC--NECGKTFSHKSSLVCHHRLH 449
Cdd:COG5048   332 LFSRNDALKRHILLHTSISPAKEKLLNSsskfsplLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITH 411

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1013394834 450 --GGEKSYKCKVCDKAFAWNSHLVRHTRIHSGGKPYKCNECGKTFGQNSDLLIHKS 503
Cdd:COG5048   412 lsFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
357-382 2.47e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.47e-04
                          10        20
                  ....*....|....*....|....*.
gi 1013394834 357 NLARHRRIHTGEKPYKCEECDKVFSR 382
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
277-298 4.43e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.43e-03
                          10        20
                  ....*....|....*....|..
gi 1013394834 277 HCRCHTGEKPYKCNECGKSFSQ 298
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
749-774 5.03e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.03e-03
                          10        20
                  ....*....|....*....|....*.
gi 1013394834 749 HLKQHTGLHTGEKPYKCNECGKAFSK 774
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 24-60 4.75e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 80.98  E-value: 4.75e-19
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1013394834  24 LTFRDVAIEFSLAEWKCLNPSQRALYREVMLENYRNL 60
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNL 38
KRAB smart00349
krueppel associated box;
24-71 2.46e-18

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 79.56  E-value: 2.46e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1013394834   24 LTFRDVAIEFSLAEWKCLNPSQRALYREVMLENYRNLEAVD--ISSKRMM 71
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGfqVPKPDLI 50
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 24-60 2.73e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 72.97  E-value: 2.73e-16
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1013394834  24 LTFRDVAIEFSLAEWKCLNPSQRALYREVMLENYRNL 60
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
341-748 6.17e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.49  E-value: 6.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 341 KPYKCNECDKAFNQQSNLARHRRIHTGEKPYKC--EECDKVFSRKSTLESHKRIHTGEKPYKC-KVCDTAFTWNSQLARH 417
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 418 KRIHTGEKTYKCNECGKTFSHKSSLVCHHRLHGGEKSYKCKVCDKAFAW----NSHLVRHTRIHSGGKPYKCNECGKTFG 493
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtpqsNSLHPPLPANSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 494 QNSDLLIHKSIHTGEQPYKYeecekvfscgSTLETHKIIHTGEKPYKCKVCDKAFACHSYLAKHTRIHSGEKPYKCNECS 573
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSI----------PSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESP 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 574 KTFRL--RSYLASHRRVHSGE-----KPYKCNECSKTFSQRSYLHCHRR--LHSGE--KPYKCNE--CGKTFSHKPSLVH 640
Cdd:COG5048   262 RSSLPtaSSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKR 341

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 641 HRRLHTGEKSYKC--TVCDKAFVRNSYLARHTRIH-----TAEKPYKC--NECGKAFNQQSQLSLHHRIHA--GEKLYKC 709
Cdd:COG5048   342 HILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLsfRPYNCKN 421

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 1013394834 710 ETCDKVFSRKSHLKRHRRIHPGKKPYKCKVCDKTFGSDS 748
Cdd:COG5048   422 PPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
313-699 7.21e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.02  E-value: 7.21e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 313 KSHKCNECGKIFGQNSALVIHKAIHTGEKPYKCN--ECDKAFNQQSNLARHRRIHTGEKPYkcEECDKVFSRKSTLESHK 390
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSD--LNSKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 391 RIHTG------EKPYKCKVCDTAFTWNSQLARHKRIHTGEKTYKCN-------------------ECGKTFSHKSSLVCH 445
Cdd:COG5048   110 LSSSSsnsndnNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNsssvntpqsnslhpplpanSLSKDPSSNLSLLIS 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 446 HRLHGGEKSYKCKVCDKAFAWNSHLVRHTRIHSGGKPYKCNECGKTFGQNSDLLIHKSIHTGEQPYKYEECEKVFSCGST 525
Cdd:COG5048   190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTAS 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 526 LETHKIIHTGE-------KPYKCKVCDKAFACHSYLAKHTR--IHSGE--KPYKCNE--CSKTFRLRSYLASHRRVHSGE 592
Cdd:COG5048   270 SQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSI 349

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 593 KPYKC--NECSKTFSQRS--YLHCHRRLHSGEKPYKCNECGKTFSHKPSLV-HHRRLHT------GEKSYKCTVCDKAFV 661
Cdd:COG5048   350 SPAKEklLNSSSKFSPLLnnEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRdSNLSLHIithlsfRPYNCKNPPCSKSFN 429

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 1013394834 662 RNSYLARHTRIHTAEKPYkCNECGKAFNQQSQLSLHHR 699
Cdd:COG5048   430 RHYNLIPHKKIHTNHAPL-LCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
182-585 8.76e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 8.76e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 182 KSTSDAPSVSTSQRISPRPQIHiSNNYGNNSPNSSLLPQKQEvymreKSFQCNESGKAFNCSSL--LRKHQIPHLGDKQY 259
Cdd:COG5048    19 TPKSTLKSLSNAPRPDSCPNCT-DSFSRLEHLTRHIRSHTGE-----KPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSD 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 260 KCDvcgKLFNHKQYLTCHCR----CHTGEKPYKCNECGKSFSQVSSLTCHRRLHTAVKSHKCNECGKIFGQ--------- 326
Cdd:COG5048    93 LNS---KSLPLSNSKASSSSlsssSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtpqsnslhp 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 327 -------------NSALVIHKAIHTGEKPYKCNECDKAFNQQSNLARHRRIHTGEKPYKCEECDKVFSRKSTLESHKRIH 393
Cdd:COG5048   170 plpanslskdpssNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLS 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 394 TGEKPYKCKVCDTAFTWNSQLARHKRIHTGEKT-------YKCNECGKTFSHKSSLVCH--HRLHGGE--KSYKCKV--C 460
Cdd:COG5048   250 SSDSSSSASESPRSSLPTASSQSSSPNESDSSSekgfslpIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslC 329

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 461 DKAFAWNSHLVRHTRIHSGGKPYKC--NECGKTFGQNSD------LLIHKSIHTGEQPYK-YEECEKVFSCGSTLETHKI 531
Cdd:COG5048   330 GKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqsLQQYKDLKNDKKSETlSNSCIRNFKRDSNLSLHII 409

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1013394834 532 IHTGEKP--YKCKVCDKAFACHSYLAKHTRIHSgEKPYKCNECSKTFRLRSYLASH 585
Cdd:COG5048   410 THLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
397-785 1.77e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.78  E-value: 1.77e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 397 KPYKCKVCDTAFTWNSQLARHKRIHTGEKTYKCN--ECGKTFSHKSSLVCHHRLHGGEKSYKCkvCDKAFAWNSHLVRHT 474
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 475 RIHSGGKPYKCN-ECGKTFGQNSdllIHKSIHTGEQPYKYEECEKV---FSCGSTLETHKIIHTGEKPYKCKVCDKAFAC 550
Cdd:COG5048   110 LSSSSSNSNDNNlLSSHSLPPSS---RDPQLPDLLSISNLRNNPLPgnnSSSVNTPQSNSLHPPLPANSLSKDPSSNLSL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 551 HSylakHTRIHSGEKPYKCNECSKTFRLRSYLASHRRVHSGEKPYKCNECSKTFSQRSYLHCHRRLHSGEKPYKCNECG- 629
Cdd:COG5048   187 LI----SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPr 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 630 ----------KTFSHKPSLVHHRRLhtgeKSYKCTVCDKAFVRNSYLARHTR--IHTAE--KPYKCNE--CGKAFNQQSQ 693
Cdd:COG5048   263 sslptassqsSSPNESDSSSEKGFS----LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDA 338

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 694 LSLHHRIHAGEKLYKC--ETCDKVFSRKSHLKRH--RRIHPGKKPYKCKVCD-----KTFGSDSHLKQHTGLHTGEKPY- 763
Cdd:COG5048   339 LKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPqsLQQYKDLKNDKKSETLsnsciRNFKRDSNLSLHIITHLSFRPYn 418

                         410       420
                  ....*....|....*....|...
gi 1013394834 764 -KCNECGKAFSKQSTLIHHQAVH 785
Cdd:COG5048   419 cKNPPCSKSFNRHYNLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
154-503 3.75e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 3.75e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 154 DQLGSSFYSHLPELHIIQIKGKIGNQFEKSTSDAPSVSTSQRISPRPQIHISNNYGNNSpNSSLLPQKQEVYMREKSFQC 233
Cdd:COG5048    96 KSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGN-NSSSVNTPQSNSLHPPLPAN 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 234 NESGKAFNCSSLLRKHQIPHlGDKQYKCDVCGKLFNHKQYLTCHCRCHTGEKPYKCNECGKSFSQvsSLTCHRRLHTAVK 313
Cdd:COG5048   175 SLSKDPSSNLSLLISSNVST-SIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPK--SLLSQSPSSLSSS 251

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 314 --SHKCNECGKIFGQNSALVIHKAIHTGE-------KPYKCNECDKAFNQQSNLARHRR--IHTGE--KPYKCEE--CDK 378
Cdd:COG5048   252 dsSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGK 331

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 379 VFSRKSTLESHKRIHTGEKPYKCKVCDT-------AFTWNSQLARHKRIHTGEKTYKC--NECGKTFSHKSSLVCHHRLH 449
Cdd:COG5048   332 LFSRNDALKRHILLHTSISPAKEKLLNSsskfsplLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITH 411

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1013394834 450 --GGEKSYKCKVCDKAFAWNSHLVRHTRIHSGGKPYKCNECGKTFGQNSDLLIHKS 503
Cdd:COG5048   412 lsFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
154-525 1.46e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 1.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 154 DQLGSSFYSHLPELHIIQIKGKIGNQFEKSTSDAPSV-STSQRISPRPQIHISNNYGNNSPNSSLLPqkqEVYMREKSFQ 232
Cdd:COG5048    77 LELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSsSNSNDNNLLSSHSLPPSSRDPQLPDLLSI---SNLRNNPLPG 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 233 CNESGKAFNCSSLLRkHQIPHlgdkqykcDVCGKLFNHKQYLTCHCRCHTGEKPYKCNECGKSFSQVSSLTCHRRLHTAV 312
Cdd:COG5048   154 NNSSSVNTPQSNSLH-PPLPA--------NSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSS 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 313 KSHKCNECGKIFGQNSALVIHKAIHTGEKPYKCNECDKAFNQQSNLARHRRIHTGE-------KPYKCEECDKVFSRKST 385
Cdd:COG5048   225 SSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSP 304

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 386 LESHKR--IHTGE--KPYKCKV--CDTAFTWNSQLARHKRIHTGEKTYKC--NECGKTFSHKS------SLVCHHRLHGG 451
Cdd:COG5048   305 LTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnneppqSLQQYKDLKND 384

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1013394834 452 EKSYKCKVCDKAFAWNSHLV---RHTRIHSGGKPYKCNECGKTFGQNSDLLIHKSIHTGEQPYKYEECEKVFSCGST 525
Cdd:COG5048   385 KKSETLSNSCIRNFKRDSNLslhIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
zf-H2C2_2 pfam13465
Zinc-finger double domain;
357-382 2.47e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.47e-04
                          10        20
                  ....*....|....*....|....*.
gi 1013394834 357 NLARHRRIHTGEKPYKCEECDKVFSR 382
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 339-418 3.96e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 3.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 339 GEKPYKCN--ECDKAFNQQSNLARHRrIHTGEKPYKCEECDKvfsrkstlESHKRIHTGEKPYKCKVCDTAFTWNSQLAR 416
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM-LHGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 1013394834 417 HK 418
Cdd:COG5189   417 HR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 676-755 7.52e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 7.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 676 EKPYKCN--ECGKAFNQQSQLSlHHRIHAGEKLYKCETCDKVfsrkshlkRHRRIHPGKKPYKCKVCDKTFGSDSHLKQH 753
Cdd:COG5189   347 GKPYKCPveGCNKKYKNQNGLK-YHMLHGHQNQKLHENPSPE--------KMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417


                  ..
gi 1013394834 754 TG 755
Cdd:COG5189   418 RK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
665-690 9.85e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 9.85e-04
                          10        20
                  ....*....|....*....|....*.
gi 1013394834 665 YLARHTRIHTAEKPYKCNECGKAFNQ 690
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
721-744 1.10e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.10e-03
                          10        20
                  ....*....|....*....|....
gi 1013394834 721 HLKRHRRIHPGKKPYKCKVCDKTF 744
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
526-550 1.32e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.32e-03
                          10        20
                  ....*....|....*....|....*
gi 1013394834 526 LETHKIIHTGEKPYKCKVCDKAFAC 550
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
414-438 1.49e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.49e-03
                          10        20
                  ....*....|....*....|....*
gi 1013394834 414 LARHKRIHTGEKTYKCNECGKTFSH 438
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 707-729 2.15e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 2.15e-03
                          10        20
                  ....*....|....*....|...
gi 1013394834 707 YKCETCDKVFSRKSHLKRHRRIH 729
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 479-562 2.61e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 2.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 479 GGKPYKCN--ECGKTFGQNSDLLIHKsihtgeqpyKYEECEKVFSCGSTLETHKIIHTGEKPYKCKVCDKAFACHSYLAK 556
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1013394834 557 HtRIHS 562
Cdd:COG5189   417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
329-354 2.82e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.82e-03
                          10        20
                  ....*....|....*....|....*.
gi 1013394834 329 ALVIHKAIHTGEKPYKCNECDKAFNQ 354
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
675-734 3.02e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 3.02e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1013394834 675 AEKPYKCNECGKAFNQQSQLSLHHRIHAGEKLYKC--ETCDKVFSRKSHLKRHRRIHPGKKP 734
Cdd:COG5048    30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPS 91
zf-H2C2_2 pfam13465
Zinc-finger double domain;
277-298 4.43e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.43e-03
                          10        20
                  ....*....|....*....|..
gi 1013394834 277 HCRCHTGEKPYKCNECGKSFSQ 298
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 283-362 4.54e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 4.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 283 GEKPYKCN--ECGKSFSQVSSLTCHRrLHtavkshkcNECGKIFGQNSALVIHKAIHTGEKPYKCNECDKAFNQQSNLAR 360
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM-LH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 1013394834 361 HR 362
Cdd:COG5189   417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
749-774 5.03e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.03e-03
                          10        20
                  ....*....|....*....|....*.
gi 1013394834 749 HLKQHTGLHTGEKPYKCNECGKAFSK 774
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
581-606 6.82e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.82e-03
                          10        20
                  ....*....|....*....|....*.
gi 1013394834 581 YLASHRRVHSGEKPYKCNECSKTFSQ 606
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
553-576 6.89e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.89e-03
                          10        20
                  ....*....|....*....|....
gi 1013394834 553 YLAKHTRIHSGEKPYKCNECSKTF 576
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
469-492 7.31e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.31e-03
                          10        20
                  ....*....|....*....|....
gi 1013394834 469 HLVRHTRIHSGGKPYKCNECGKTF 492
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 584-669 7.70e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 7.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013394834 584 SHRRVHSGEKPYKCN--ECSKTFSQRSYLHCHRrLHSgekpykcnECGKTFSHKPSLVHHRRLHTGEKSYKCTVCDKAFV 661
Cdd:COG5189   339 SRMLKVKDGKPYKCPveGCNKKYKNQNGLKYHM-LHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYK 409


                  ....*...
gi 1013394834 662 RNSYLARH 669
Cdd:COG5189   410 NLNGLKYH 417
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH