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ZNF524 zinc finger protein 524 [ Homo sapiens (human) ]

Gene ID: 147807, updated on 2-Nov-2024

Summary

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Official Symbol
ZNF524provided by HGNC
Official Full Name
zinc finger protein 524provided by HGNC
Primary source
HGNC:HGNC:28322
See related
Ensembl:ENSG00000171443 AllianceGenome:HGNC:28322
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in fat (RPKM 6.3), spleen (RPKM 5.6) and 25 other tissues See more
Orthologs
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Genomic context

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See ZNF524 in Genome Data Viewer
Location:
19q13.42
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (55599574..55603138)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (58695510..58699073)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (56111654..56114504)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 579 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11043 Neighboring gene Sharpr-MPRA regulatory region 13032 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11045 Neighboring gene FLT3 interacting zinc finger 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:56110254-56111128 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:56111129-56112002 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:56113981-56114531 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:56115635-56116186 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:56116187-56116738 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11048 Neighboring gene zinc finger protein 865 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15098 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:56135913-56136412 Neighboring gene zinc finger protein 784

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genome-wide association study of chronic periodontitis in a general German population. Teumer A, et al. J Clin Periodontol, 2013 Nov. PMID 24024966
  2. The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis. Oliviero G, et al. Sci Rep, 2015 Dec 21. PMID 26687479, Free PMC Article
  3. Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells. Oliviero G, et al. Mol Cell Proteomics, 2016 Nov. PMID 27634302, Free PMC Article
  4. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Yin Y, et al. Science, 2017 May 5. PMID 28473536, Free PMC Article
  5. Transcriptome analysis of human gastric cancer. Oh JH, et al. Mamm Genome, 2005 Dec. PMID 16341674

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of chronic periodontitis in a general German population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC23143

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 524

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153219.4 → NP_694951.1  zinc finger protein 524

    See identical proteins and their annotated locations for NP_694951.1

    Status: VALIDATED

    Source sequence(s)
    AC008735, BC014666, BC067748, HY097571
    Consensus CDS
    CCDS12929.1
    UniProtKB/Swiss-Prot
    Q6NW31, Q96C55, Q96IL7
    Related
    ENSP00000301073.2, ENST00000301073.4
    Conserved Domains (3) summary
    PHA00733
    Location:169 → 221
    PHA00733; hypothetical protein
    COG5048
    Location:113 → 177
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:144 → 164
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    55599574..55603138
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526487.3 → XP_011524789.1  zinc finger protein 524 isoform X1

    Conserved Domains (3) summary
    COG5048
    Location:219 → 283
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:250 → 270
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:234 → 259
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    58695510..58699073
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054319881.1 → XP_054175856.1  zinc finger protein 524 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96C55.1 GenPept UniProtKB/Swiss-Prot:Q96C55

Gene LinkOut

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