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Slc37a4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 [ Mus musculus (house mouse) ]

Gene ID: 14385, updated on 2-Nov-2024

Summary

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Official Symbol
Slc37a4provided by MGI
Official Full Name
solute carrier family 37 (glucose-6-phosphate transporter), member 4provided by MGI
Primary source
MGI:MGI:1316650
See related
Ensembl:ENSMUSG00000032114 AllianceGenome:MGI:1316650
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
G6PT; G6pt1; mG6PT; GSD-1b; 100043178
Summary
Enables glucose 6-phosphate:phosphate antiporter activity. Involved in gluconeogenesis. Acts upstream of or within several processes, including cholesterol homeostasis; glucose-6-phosphate transport; and hemopoiesis. Is active in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; liver; and spleen. Used to study glycogen storage disease Ia. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II; glycogen storage disease Ib; and glycogen storage disease Ic. Orthologous to human SLC37A4 (solute carrier family 37 member 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in kidney adult (RPKM 71.2), liver adult (RPKM 39.6) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Slc37a4 in Genome Data Viewer
Location:
9 A5.2; 9 24.84 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (44308243..44314263)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (44396946..44402966)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1785 Neighboring gene hypoxia up-regulated 1 Neighboring gene STARR-positive B cell enhancer ABC_E5063 Neighboring gene predicted gene, 26306 Neighboring gene microRNA 7085 Neighboring gene trafficking protein particle complex 4 Neighboring gene STARR-positive B cell enhancer ABC_E2291 Neighboring gene ribosomal protein S25 Neighboring gene centrosomal AT-AC splicing factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Development and characterization of an inducible mouse model for glycogen storage disease type Ib. Raggi F, et al. J Inherit Metab Dis, 2018 Nov. PMID 29967951
  2. Liver-directed gene therapy for murine glycogen storage disease type Ib. Kwon JH, et al. Hum Mol Genet, 2017 Nov 15. PMID 28973635, Free PMC Article
  3. Downregulation of pathways implicated in liver inflammation and tumorigenesis of glycogen storage disease type Ia mice receiving gene therapy. Kim GY, et al. Hum Mol Genet, 2017 May 15. PMID 28334808, Free PMC Article
  4. Glycogen storage disease type Ib neutrophils exhibit impaired cell adhesion and migration. Kim GY, et al. Biochem Biophys Res Commun, 2017 Jan 22. PMID 27864142, Free PMC Article
  5. Global gene expression analysis to identify molecular markers of uterine receptivity and embryo implantation. Reese J, et al. J Biol Chem, 2001 Nov 23. PMID 11551965

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Specific reduction of G6PT may contribute to downregulation of hepatic 11beta-HSD1 in diabetic mice.
    Title: Specific reduction of G6PT may contribute to downregulation of hepatic 11β-HSD1 in diabetic mice.
  2. hepatic G6PT functions as an uniporter
    Title: The glucose-6-phosphate transport is not mediated by a glucose-6-phosphate/phosphate exchange in liver microsomes.
  3. Findings suggest that increased hepatic H6PDH and G6PT production contribute to 11beta-HSD1 upregulation of local glucocorticoid action that may be related to the development of type 2 diabetes.
    Title: Tissue-specific dysregulation of hexose-6-phosphate dehydrogenase and glucose-6-phosphate transporter production in db/db mice as a model of type 2 diabetes.
  4. Data suggest that G6PT may account for the metabolic flexibility that enables MSCs to survive under conditions characterized by hypoxia and could be specifically targeted within developing tumors.
    Title: Evidence for transcriptional regulation of the glucose-6-phosphate transporter by HIF-1alpha: Targeting G6PT with mumbaistatin analogs in hypoxic mesenchymal stromal cells.
  5. there is an MT1-MMP/G6PT signaling axis that regulates BMSC survival, ECM degradation, and mobilization
    Title: MT1-MMP down-regulates the glucose 6-phosphate transporter expression in marrow stromal cells: a molecular link between pro-MMP-2 activation, chemotaxis, and cell survival.
  6. Glc-6-PT expression in bone marrow and neutrophils is required for normal myeloid functions
    Title: Bone marrow-derived cells require a functional glucose 6-phosphate transporter for normal myeloid functions.
  7. Evidence for the expression of G6PT1 in pancreatic islets.
    Title: Evidence for the expression of both the hydrolase and translocase components of hepatic glucose-6-phosphatase in murine pancreatic islets.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (3)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glucose 6-phosphate:phosphate antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucose 6-phosphate:phosphate antiporter activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables glucose 6-phosphate:phosphate antiporter activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables glucose-6-phosphate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of chemokine production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cholesterol homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cytokine production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gluconeogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glucose homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in glucose-6-phosphate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within glucose-6-phosphate transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within glucose-6-phosphate transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within glucose-6-phosphate transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glucose-6-phosphate transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within glycogen metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within intracellular calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lactate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within myeloid progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of chemokine production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neutrophil chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neutrophil homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphate ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphate ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of catalytic activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within post-embryonic hemopoiesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within respiratory burst IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within steroid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within triglyceride metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum membrane IGI
Inferred from Genetic Interaction
more info
 PubMed 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
glucose-6-phosphate exchanger SLC37A4
Names
glucose 6-phosphate transporter
glucose-6-phosphatase, transport protein 1
solute carrier family 37 (glycerol-6-phosphate transporter), member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293630.2 → NP_001280559.1  glucose-6-phosphate exchanger SLC37A4 isoform b

    See identical proteins and their annotated locations for NP_001280559.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 4. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 1-3 and 7 all encode the same isoform (b).
    Source sequence(s)
    AC122428
    Consensus CDS
    CCDS23108.1
    UniProtKB/TrEMBL
    Q6WG34, Q9D1F9
    Related
    ENSMUSP00000150843.2, ENSMUST00000213388.2
    Conserved Domains (1) summary
    cd17343
    Location:10 → 417
    MFS_SLC37A4; Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters

  2. NM_001293631.2 → NP_001280560.1  glucose-6-phosphate exchanger SLC37A4 isoform b

    See identical proteins and their annotated locations for NP_001280560.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 4. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 1-3 and 7 all encode the same isoform (b).
    Source sequence(s)
    AC122428
    Consensus CDS
    CCDS23108.1
    UniProtKB/TrEMBL
    Q6WG34, Q9D1F9
    Related
    ENSMUSP00000148956.2, ENSMUST00000215420.2
    Conserved Domains (1) summary
    cd17343
    Location:10 → 417
    MFS_SLC37A4; Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters

  3. NM_001357729.2 → NP_001344658.1  glucose-6-phosphate exchanger SLC37A4 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (a). Variants 4-6 all encode the same isoform (a).
    Source sequence(s)
    AC122428
    Consensus CDS
    CCDS90548.1
    UniProtKB/TrEMBL
    A0A1L1SUI3, Q6WG34
    Conserved Domains (1) summary
    cd17343
    Location:10 → 438
    MFS_SLC37A4; Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters

  4. NM_001357730.2 → NP_001344659.1  glucose-6-phosphate exchanger SLC37A4 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) encodes the longest isoform (a). Variants 4-6 all encode the same isoform (a).
    Source sequence(s)
    AC122428
    Consensus CDS
    CCDS90548.1
    UniProtKB/TrEMBL
    A0A1L1SUI3, Q6WG34
    Conserved Domains (1) summary
    cd17343
    Location:10 → 438
    MFS_SLC37A4; Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters

  5. NM_001378829.1 → NP_001365758.1  glucose-6-phosphate exchanger SLC37A4 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 4 and 5, encodes the longest isoform (a).
    Source sequence(s)
    AC122428
    UniProtKB/TrEMBL
    A0A1L1SUI3, Q6WG34
    Related
    ENSMUSP00000150753.2, ENSMUST00000213268.2
    Conserved Domains (1) summary
    cd17343
    Location:10 → 438
    MFS_SLC37A4; Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters

  6. NM_001378830.1 → NP_001365759.1  glucose-6-phosphate exchanger SLC37A4 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variants 1-3, encodes isoform b.
    Source sequence(s)
    AC122428
    UniProtKB/TrEMBL
    Q6WG34, Q9D1F9
    Conserved Domains (1) summary
    cd17343
    Location:10 → 417
    MFS_SLC37A4; Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters

  7. NM_001378831.1 → NP_001365760.1  glucose-6-phosphate exchanger SLC37A4 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variants 9 and 10, encodes isoform c.
    Source sequence(s)
    AC122428
    UniProtKB/TrEMBL
    Q6WG34
    Conserved Domains (1) summary
    cd17343
    Location:20 → 409
    MFS_SLC37A4; Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters

  8. NM_001378832.1 → NP_001365761.1  glucose-6-phosphate exchanger SLC37A4 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9), as well as variants 8 and 10, encodes isoform c.
    Source sequence(s)
    AC122428
    UniProtKB/TrEMBL
    Q6WG34
    Conserved Domains (1) summary
    cd17343
    Location:20 → 409
    MFS_SLC37A4; Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters

  9. NM_001378833.1 → NP_001365762.1  glucose-6-phosphate exchanger SLC37A4 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variants 8 and 9, encodes isoform c.
    Source sequence(s)
    AC122428
    UniProtKB/TrEMBL
    Q6WG34
    Conserved Domains (1) summary
    cd17343
    Location:20 → 409
    MFS_SLC37A4; Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters

  10. NM_001378834.1 → NP_001365763.1  glucose-6-phosphate exchanger SLC37A4 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC122428
    UniProtKB/TrEMBL
    Q6WG34
    Conserved Domains (1) summary
    cd17343
    Location:20 → 388
    MFS_SLC37A4; Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters

  11. NM_001411170.1 → NP_001398099.1  glucose-6-phosphate exchanger SLC37A4 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC122428

  12. NM_008063.3 → NP_032089.2  glucose-6-phosphate exchanger SLC37A4 isoform b

    See identical proteins and their annotated locations for NP_032089.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 4. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 1-3 and 7 all encode the same isoform (b).
    Source sequence(s)
    AC122428
    Consensus CDS
    CCDS23108.1
    UniProtKB/TrEMBL
    Q6WG34, Q9D1F9
    Related
    ENSMUSP00000129564.2, ENSMUST00000165839.3
    Conserved Domains (1) summary
    cd17343
    Location:10 → 417
    MFS_SLC37A4; Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    44308243..44314263
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244053.2 → XP_030099913.1  glucose-6-phosphate exchanger SLC37A4 isoform X1

    UniProtKB/TrEMBL
    Q6WG34, Q9D1F9
    Conserved Domains (1) summary
    cd17343
    Location:10 → 417
    MFS_SLC37A4; Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters
Nucleotide Protein Strain
Heading Accession and Version

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