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FAM168B family with sequence similarity 168 member B [ Homo sapiens (human) ]

Gene ID: 130074, updated on 2-Nov-2024

Summary

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Official Symbol
FAM168Bprovided by HGNC
Official Full Name
family with sequence similarity 168 member Bprovided by HGNC
Primary source
HGNC:HGNC:27016
See related
Ensembl:ENSG00000152102 MIM:620078; AllianceGenome:HGNC:27016
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MANI
Summary
Located in extracellular exosome. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in brain (RPKM 37.0), fat (RPKM 23.7) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See FAM168B in Genome Data Viewer
Location:
2q21.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (131047876..131093460, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (131482169..131527429, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (131805449..131851033, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 4 Neighboring gene small Cajal body-specific RNA 4 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:131706954-131707281 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:131724236-131724855 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:131743536-131744354 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:131799328-131800200 Neighboring gene small integral membrane protein 39 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11964 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:131855480-131855651 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:131856285-131856785 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16531 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:131871473-131872062 Neighboring gene pleckstrin homology domain containing B2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16533 Neighboring gene NEK2 pseudogene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC87527

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular exosome HDA PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
myelin-associated neurite-outgrowth inhibitor
Names
protein FAM168B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009993.4 → NP_001009993.2  myelin-associated neurite-outgrowth inhibitor

    See identical proteins and their annotated locations for NP_001009993.2

    Status: VALIDATED

    Source sequence(s)
    BC110642, CN418443, DB453209
    Consensus CDS
    CCDS42755.1
    UniProtKB/Swiss-Prot
    A1KXE4, Q2TAZ6, Q6NZ40
    Related
    ENSP00000374565.3, ENST00000389915.4
    Conserved Domains (1) summary
    pfam14944
    Location:1 → 195
    TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

  2. NM_001321743.1 → NP_001308672.1  myelin-associated neurite-outgrowth inhibitor

    Status: VALIDATED

    Source sequence(s)
    AC009477
    Consensus CDS
    CCDS42755.1
    UniProtKB/Swiss-Prot
    A1KXE4, Q2TAZ6, Q6NZ40
    Conserved Domains (1) summary
    pfam14944
    Location:1 → 195
    TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

  3. NM_001321744.1 → NP_001308673.1  myelin-associated neurite-outgrowth inhibitor

    Status: VALIDATED

    Source sequence(s)
    AC009477
    Consensus CDS
    CCDS42755.1
    UniProtKB/Swiss-Prot
    A1KXE4, Q2TAZ6, Q6NZ40
    Conserved Domains (1) summary
    pfam14944
    Location:1 → 195
    TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

  4. NM_001321745.1 → NP_001308674.1  myelin-associated neurite-outgrowth inhibitor

    Status: VALIDATED

    Source sequence(s)
    AC009477
    Consensus CDS
    CCDS42755.1
    UniProtKB/Swiss-Prot
    A1KXE4, Q2TAZ6, Q6NZ40
    Conserved Domains (1) summary
    pfam14944
    Location:1 → 195
    TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

  5. NM_001321746.2 → NP_001308675.1  myelin-associated neurite-outgrowth inhibitor

    Status: VALIDATED

    Source sequence(s)
    AC009477, BC110642, CN418443
    Consensus CDS
    CCDS42755.1
    UniProtKB/Swiss-Prot
    A1KXE4, Q2TAZ6, Q6NZ40
    Related
    ENSP00000387051.1, ENST00000409185.5
    Conserved Domains (1) summary
    pfam14944
    Location:1 → 195
    TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

  6. NM_001321747.2 → NP_001308676.1  myelin-associated neurite-outgrowth inhibitor

    Status: VALIDATED

    Source sequence(s)
    AC009477
    Consensus CDS
    CCDS42755.1
    UniProtKB/Swiss-Prot
    A1KXE4, Q2TAZ6, Q6NZ40
    Conserved Domains (1) summary
    pfam14944
    Location:1 → 195
    TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

  7. NM_001321748.2 → NP_001308677.1  myelin-associated neurite-outgrowth inhibitor

    Status: VALIDATED

    Source sequence(s)
    AC009477
    Consensus CDS
    CCDS42755.1
    UniProtKB/Swiss-Prot
    A1KXE4, Q2TAZ6, Q6NZ40
    Conserved Domains (1) summary
    pfam14944
    Location:1 → 195
    TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    131047876..131093460 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047443337.1 → XP_047299293.1  myelin-associated neurite-outgrowth inhibitor isoform X1

    UniProtKB/Swiss-Prot
    A1KXE4, Q2TAZ6, Q6NZ40

  2. XM_047443336.1 → XP_047299292.1  myelin-associated neurite-outgrowth inhibitor isoform X1

    UniProtKB/Swiss-Prot
    A1KXE4, Q2TAZ6, Q6NZ40

  3. XM_017003327.2 → XP_016858816.1  myelin-associated neurite-outgrowth inhibitor isoform X1

    UniProtKB/Swiss-Prot
    A1KXE4, Q2TAZ6, Q6NZ40
    Conserved Domains (1) summary
    pfam14944
    Location:1 → 195
    TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

  4. XM_047443338.1 → XP_047299294.1  myelin-associated neurite-outgrowth inhibitor isoform X1

    UniProtKB/Swiss-Prot
    A1KXE4, Q2TAZ6, Q6NZ40

  5. XM_047443339.1 → XP_047299295.1  myelin-associated neurite-outgrowth inhibitor isoform X1

    UniProtKB/Swiss-Prot
    A1KXE4, Q2TAZ6, Q6NZ40

  6. XM_011510594.4 → XP_011508896.1  myelin-associated neurite-outgrowth inhibitor isoform X2

    See identical proteins and their annotated locations for XP_011508896.1

    Conserved Domains (1) summary
    pfam14944
    Location:24 → 168
    TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    131482169..131527429 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054340506.1 → XP_054196481.1  myelin-associated neurite-outgrowth inhibitor isoform X1

    UniProtKB/Swiss-Prot
    A1KXE4, Q2TAZ6, Q6NZ40

  2. XM_054340505.1 → XP_054196480.1  myelin-associated neurite-outgrowth inhibitor isoform X1

    UniProtKB/Swiss-Prot
    A1KXE4, Q2TAZ6, Q6NZ40

  3. XM_054340504.1 → XP_054196479.1  myelin-associated neurite-outgrowth inhibitor isoform X1

    UniProtKB/Swiss-Prot
    A1KXE4, Q2TAZ6, Q6NZ40

  4. XM_054340508.1 → XP_054196483.1  myelin-associated neurite-outgrowth inhibitor isoform X1

    UniProtKB/Swiss-Prot
    A1KXE4, Q2TAZ6, Q6NZ40

  5. XM_054340507.1 → XP_054196482.1  myelin-associated neurite-outgrowth inhibitor isoform X1

    UniProtKB/Swiss-Prot
    A1KXE4, Q2TAZ6, Q6NZ40

  6. XM_054340509.1 → XP_054196484.1  myelin-associated neurite-outgrowth inhibitor isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1KXE4.1 GenPept UniProtKB/Swiss-Prot:A1KXE4

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