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Conserved domains on  [gi|1012443707|ref|NP_001308677|]
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myelin-associated neurite-outgrowth inhibitor [Homo sapiens]

Protein Classification

TCRP1 domain-containing protein( domain architecture ID 12171678)

TCRP1 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TCRP1 pfam14944
Tongue Cancer Chemotherapy Resistant Protein 1; This family of proteins are found in ...
1-195 3.64e-72

Tongue Cancer Chemotherapy Resistant Protein 1; This family of proteins are found in eukaryotes. Tongue Cancer Chemotherapy Resistant-associated Protein 1 (TCRP1) is resistant to the chemotherapy drug, cisplatin, which induces apoptosis in tumour cells. There is suggestion that TCRP1 can be targeted to reverse chemotherapy resistance. The precise mechanism of TCRP1 inducing resistance against chemotherapy is still not clear, but it is thought that TCRP1 alters cell signalling pathways affecting apoptosis or DNA repair capacity. Proteins in this family are typically between 194 and 235 amino acids in length.


:

Pssm-ID: 434335 [Multi-domain]  Cd Length: 237  Bit Score: 218.25  E-value: 3.64e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443707   1 MNPVYSPGSSGVPYANAKGIGYPAGFPMGYAAAAPAYSPNMYPGANPTFQTG---------------------------- 52
Cdd:pfam14944   1 MNPVYSPVQPGVPYGNPKGMAYPAGFPVGYAAAAPAYTPNMYPGASPGFPPGeqlhesawggfsshsndrsclsfkcdqg 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443707  53 --------------YTPGTPYKVSCSPTSGAVPPYSSSPNPYQTAVYPVRSAYPQQSPYAQQGTYYTQPLYAAPPHVIHH 118
Cdd:pfam14944  81 tkrrtltsssaafrYTPGTPYKVSPSPSNGAVPPYSSSPNPYPTAVYPIRSAYPQQNPYAQQGAYYTQPLYAAQPHVIHH 160
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1012443707 119 TTVVQPNGMPATVYPAPIPPPRGNGVTMGMVAGTTMAMSAGTLLTAHSPTPVAPHPVTVPTYRAPGTPTYSYVPPQW 195
Cdd:pfam14944 161 TTVVQPNGMPAAMYPAPIPPPRNNGVAMGMVAGTTMAMSAGTLLTTPSPTPVGPHPVTVPTYRPPGTPTYSYVPPQW 237
 
Name Accession Description Interval E-value
TCRP1 pfam14944
Tongue Cancer Chemotherapy Resistant Protein 1; This family of proteins are found in ...
1-195 3.64e-72

Tongue Cancer Chemotherapy Resistant Protein 1; This family of proteins are found in eukaryotes. Tongue Cancer Chemotherapy Resistant-associated Protein 1 (TCRP1) is resistant to the chemotherapy drug, cisplatin, which induces apoptosis in tumour cells. There is suggestion that TCRP1 can be targeted to reverse chemotherapy resistance. The precise mechanism of TCRP1 inducing resistance against chemotherapy is still not clear, but it is thought that TCRP1 alters cell signalling pathways affecting apoptosis or DNA repair capacity. Proteins in this family are typically between 194 and 235 amino acids in length.


Pssm-ID: 434335 [Multi-domain]  Cd Length: 237  Bit Score: 218.25  E-value: 3.64e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443707   1 MNPVYSPGSSGVPYANAKGIGYPAGFPMGYAAAAPAYSPNMYPGANPTFQTG---------------------------- 52
Cdd:pfam14944   1 MNPVYSPVQPGVPYGNPKGMAYPAGFPVGYAAAAPAYTPNMYPGASPGFPPGeqlhesawggfsshsndrsclsfkcdqg 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443707  53 --------------YTPGTPYKVSCSPTSGAVPPYSSSPNPYQTAVYPVRSAYPQQSPYAQQGTYYTQPLYAAPPHVIHH 118
Cdd:pfam14944  81 tkrrtltsssaafrYTPGTPYKVSPSPSNGAVPPYSSSPNPYPTAVYPIRSAYPQQNPYAQQGAYYTQPLYAAQPHVIHH 160
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1012443707 119 TTVVQPNGMPATVYPAPIPPPRGNGVTMGMVAGTTMAMSAGTLLTAHSPTPVAPHPVTVPTYRAPGTPTYSYVPPQW 195
Cdd:pfam14944 161 TTVVQPNGMPAAMYPAPIPPPRNNGVAMGMVAGTTMAMSAGTLLTTPSPTPVGPHPVTVPTYRPPGTPTYSYVPPQW 237
PHA03247 PHA03247
large tegument protein UL36; Provisional
51-187 9.86e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 36.45  E-value: 9.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443707   51 TGYTPGTPYKVSCSPTSGAVPPYSSSPNPYQTAVYPVRSAYPQQSPYAQQGTYYTQPLYAAPPHVIHHTTVVQPNGMPAT 130
Cdd:PHA03247  2713 HALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLS 2792
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1012443707  131 VYPAPIPPPRGNGVTMGMVAGTTMAMSAGTLLTAHSPTPVAPHPVTVPTYRAPGTPT 187
Cdd:PHA03247  2793 ESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPS 2849
 
Name Accession Description Interval E-value
TCRP1 pfam14944
Tongue Cancer Chemotherapy Resistant Protein 1; This family of proteins are found in ...
1-195 3.64e-72

Tongue Cancer Chemotherapy Resistant Protein 1; This family of proteins are found in eukaryotes. Tongue Cancer Chemotherapy Resistant-associated Protein 1 (TCRP1) is resistant to the chemotherapy drug, cisplatin, which induces apoptosis in tumour cells. There is suggestion that TCRP1 can be targeted to reverse chemotherapy resistance. The precise mechanism of TCRP1 inducing resistance against chemotherapy is still not clear, but it is thought that TCRP1 alters cell signalling pathways affecting apoptosis or DNA repair capacity. Proteins in this family are typically between 194 and 235 amino acids in length.


Pssm-ID: 434335 [Multi-domain]  Cd Length: 237  Bit Score: 218.25  E-value: 3.64e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443707   1 MNPVYSPGSSGVPYANAKGIGYPAGFPMGYAAAAPAYSPNMYPGANPTFQTG---------------------------- 52
Cdd:pfam14944   1 MNPVYSPVQPGVPYGNPKGMAYPAGFPVGYAAAAPAYTPNMYPGASPGFPPGeqlhesawggfsshsndrsclsfkcdqg 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443707  53 --------------YTPGTPYKVSCSPTSGAVPPYSSSPNPYQTAVYPVRSAYPQQSPYAQQGTYYTQPLYAAPPHVIHH 118
Cdd:pfam14944  81 tkrrtltsssaafrYTPGTPYKVSPSPSNGAVPPYSSSPNPYPTAVYPIRSAYPQQNPYAQQGAYYTQPLYAAQPHVIHH 160
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1012443707 119 TTVVQPNGMPATVYPAPIPPPRGNGVTMGMVAGTTMAMSAGTLLTAHSPTPVAPHPVTVPTYRAPGTPTYSYVPPQW 195
Cdd:pfam14944 161 TTVVQPNGMPAAMYPAPIPPPRNNGVAMGMVAGTTMAMSAGTLLTTPSPTPVGPHPVTVPTYRPPGTPTYSYVPPQW 237
PHA03247 PHA03247
large tegument protein UL36; Provisional
51-187 9.86e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 36.45  E-value: 9.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012443707   51 TGYTPGTPYKVSCSPTSGAVPPYSSSPNPYQTAVYPVRSAYPQQSPYAQQGTYYTQPLYAAPPHVIHHTTVVQPNGMPAT 130
Cdd:PHA03247  2713 HALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLS 2792
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1012443707  131 VYPAPIPPPRGNGVTMGMVAGTTMAMSAGTLLTAHSPTPVAPHPVTVPTYRAPGTPT 187
Cdd:PHA03247  2793 ESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPS 2849
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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