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TPD52-MRPS28 TPD52-MRPS28 readthrough [ Homo sapiens (human) ]

Gene ID: 124188259, updated on 10-Oct-2023

Summary

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Gene symbol
TPD52-MRPS28
Gene description
TPD52-MRPS28 readthrough
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This locus represents naturally occurring readthrough transcription between the neighboring TPD52 (tumor protein D52) and MRPS28 (mitochondrial ribosomal protein S28) genes on chromosome 8. The readthrough transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Feb 2022]
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Genomic context

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Location:
8q21.13
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (79918717..80171564, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (80350048..80603125, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (80830952..81083799, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27549 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27550 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19311 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19312 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19313 Neighboring gene uncharacterized LOC101927040 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:80695841-80696641 Neighboring gene long intergenic non-protein coding RNA 1607 Neighboring gene U7 small nuclear RNA Neighboring gene hes related family bHLH transcription factor with YRPW motif 1 Neighboring gene RNA, U7 small nuclear 85 pseudogene Neighboring gene Sharpr-MPRA regulatory region 4298 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27551 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19315 Neighboring gene uncharacterized LOC124901966 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19316 Neighboring gene mitochondrial ribosomal protein S28 Neighboring gene VISTA enhancer hs1305 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:80894241-80894806 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:80909347-80909896 Neighboring gene Sharpr-MPRA regulatory region 4480 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19317 Neighboring gene Sharpr-MPRA regulatory region 3052 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27552 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27553 Neighboring gene tumor protein D52 Neighboring gene uncharacterized LOC105375919 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19318 Neighboring gene uncharacterized LOC105375918 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:81013977-81014477 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27555 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27556 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27558 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27557 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27559 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27560 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27561 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27562 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19319 Neighboring gene uncharacterized LOC105375920 Neighboring gene RNA, 7SL, cytoplasmic 41, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19320 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19321 Neighboring gene microRNA 5708

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

General gene information

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General protein information

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Preferred Names
TPD52-MRPS28 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001387778.1 → NP_001374707.1  TPD52-MRPS28 protein

    Status: VALIDATED

    Source sequence(s)
    AC009686, AC018952, AC036214
    Conserved Domains (2) summary
    pfam04201
    Location:12 → 145
    TPD52; tumor protein D52 family
    pfam10246
    Location:148 → 252
    MRP-S35; Mitochondrial ribosomal protein MRP-S35

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    79918717..80171564 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    80350048..80603125 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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